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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHC1
Full Name:
Polyhomeotic-like protein 1
Alias:
Early development regulator 1; Early development regulatory protein 1; EDR1; PH1; RAE28
Type:
Nucleus, Nucleolus protein
Mass (Da):
105534
Number AA:
1004
UniProt ID:
P78364
International Prot ID:
IPI00555755
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
T
E
S
E
Q
N
S
N
S
T
N
G
S
S
Site 2
S11
E
S
E
Q
N
S
N
S
T
N
G
S
S
S
S
Site 3
T12
S
E
Q
N
S
N
S
T
N
G
S
S
S
S
G
Site 4
S15
N
S
N
S
T
N
G
S
S
S
S
G
G
S
S
Site 5
S16
S
N
S
T
N
G
S
S
S
S
G
G
S
S
R
Site 6
S17
N
S
T
N
G
S
S
S
S
G
G
S
S
R
P
Site 7
S18
S
T
N
G
S
S
S
S
G
G
S
S
R
P
Q
Site 8
S21
G
S
S
S
S
G
G
S
S
R
P
Q
I
A
Q
Site 9
S22
S
S
S
S
G
G
S
S
R
P
Q
I
A
Q
M
Site 10
Y32
Q
I
A
Q
M
S
L
Y
E
R
Q
A
V
Q
A
Site 11
Y52
R
Q
P
N
A
A
Q
Y
F
H
Q
F
M
L
Q
Site 12
S63
F
M
L
Q
Q
Q
L
S
N
A
Q
L
H
S
L
Site 13
S81
Q
Q
A
T
I
A
A
S
R
Q
A
S
S
P
N
Site 14
S85
I
A
A
S
R
Q
A
S
S
P
N
T
S
T
T
Site 15
S86
A
A
S
R
Q
A
S
S
P
N
T
S
T
T
Q
Site 16
T89
R
Q
A
S
S
P
N
T
S
T
T
Q
Q
Q
T
Site 17
S90
Q
A
S
S
P
N
T
S
T
T
Q
Q
Q
T
T
Site 18
S115
T
S
A
A
Q
L
I
S
R
S
Q
S
V
S
S
Site 19
S117
A
A
Q
L
I
S
R
S
Q
S
V
S
S
P
S
Site 20
S119
Q
L
I
S
R
S
Q
S
V
S
S
P
S
A
T
Site 21
S121
I
S
R
S
Q
S
V
S
S
P
S
A
T
T
L
Site 22
S122
S
R
S
Q
S
V
S
S
P
S
A
T
T
L
T
Site 23
S124
S
Q
S
V
S
S
P
S
A
T
T
L
T
Q
S
Site 24
T137
Q
S
V
L
L
G
N
T
T
S
P
P
L
N
Q
Site 25
T138
S
V
L
L
G
N
T
T
S
P
P
L
N
Q
S
Site 26
S139
V
L
L
G
N
T
T
S
P
P
L
N
Q
S
Q
Site 27
S145
T
S
P
P
L
N
Q
S
Q
A
Q
M
Y
L
R
Site 28
Y150
N
Q
S
Q
A
Q
M
Y
L
R
P
Q
L
G
N
Site 29
T164
N
L
L
Q
V
N
R
T
L
G
R
N
V
P
L
Site 30
S195
Q
E
V
P
S
A
Q
S
P
G
V
H
A
D
A
Site 31
S216
A
V
R
N
Q
Q
A
S
A
Q
G
P
Q
M
Q
Site 32
S225
Q
G
P
Q
M
Q
G
S
T
Q
K
A
I
P
P
Site 33
S235
K
A
I
P
P
G
A
S
P
V
S
S
L
S
Q
Site 34
S238
P
P
G
A
S
P
V
S
S
L
S
Q
A
S
S
Site 35
S239
P
G
A
S
P
V
S
S
L
S
Q
A
S
S
Q
Site 36
S241
A
S
P
V
S
S
L
S
Q
A
S
S
Q
A
L
Site 37
S245
S
S
L
S
Q
A
S
S
Q
A
L
A
V
A
Q
Site 38
S261
S
S
G
A
T
N
Q
S
L
N
L
S
Q
A
G
Site 39
S265
T
N
Q
S
L
N
L
S
Q
A
G
G
G
S
G
Site 40
S271
L
S
Q
A
G
G
G
S
G
N
S
I
P
G
S
Site 41
S274
A
G
G
G
S
G
N
S
I
P
G
S
M
G
P
Site 42
S278
S
G
N
S
I
P
G
S
M
G
P
G
G
G
G
Site 43
S296
G
G
L
G
Q
L
P
S
S
G
M
G
G
G
S
Site 44
S297
G
L
G
Q
L
P
S
S
G
M
G
G
G
S
C
Site 45
S303
S
S
G
M
G
G
G
S
C
P
R
K
G
T
G
Site 46
T309
G
S
C
P
R
K
G
T
G
V
V
Q
P
L
P
Site 47
T320
Q
P
L
P
A
A
Q
T
V
T
V
S
Q
G
S
Site 48
T322
L
P
A
A
Q
T
V
T
V
S
Q
G
S
Q
T
Site 49
S324
A
A
Q
T
V
T
V
S
Q
G
S
Q
T
E
A
Site 50
T329
T
V
S
Q
G
S
Q
T
E
A
E
S
A
A
A
Site 51
S344
K
K
A
E
A
D
G
S
G
Q
Q
N
V
G
M
Site 52
T354
Q
N
V
G
M
N
L
T
R
T
A
T
P
A
P
Site 53
T356
V
G
M
N
L
T
R
T
A
T
P
A
P
S
Q
Site 54
T358
M
N
L
T
R
T
A
T
P
A
P
S
Q
T
L
Site 55
S362
R
T
A
T
P
A
P
S
Q
T
L
I
S
S
A
Site 56
T364
A
T
P
A
P
S
Q
T
L
I
S
S
A
T
Y
Site 57
Y371
T
L
I
S
S
A
T
Y
T
Q
I
Q
P
H
S
Site 58
T372
L
I
S
S
A
T
Y
T
Q
I
Q
P
H
S
L
Site 59
S412
Q
Q
F
Q
H
R
Q
S
Q
L
L
H
T
A
T
Site 60
T456
Q
P
P
Q
V
P
P
T
Q
Q
V
P
P
S
Q
Site 61
S462
P
T
Q
Q
V
P
P
S
Q
S
Q
Q
Q
A
Q
Site 62
T470
Q
S
Q
Q
Q
A
Q
T
L
V
V
Q
P
M
L
Site 63
S480
V
Q
P
M
L
Q
S
S
P
L
S
L
P
P
D
Site 64
S483
M
L
Q
S
S
P
L
S
L
P
P
D
A
A
P
Site 65
S498
K
P
P
I
P
I
Q
S
K
P
P
V
A
P
I
Site 66
T561
T
S
R
G
M
P
G
T
V
Q
S
G
Q
A
H
Site 67
S564
G
M
P
G
T
V
Q
S
G
Q
A
H
L
A
S
Site 68
S571
S
G
Q
A
H
L
A
S
S
P
P
S
S
Q
A
Site 69
S572
G
Q
A
H
L
A
S
S
P
P
S
S
Q
A
P
Site 70
S575
H
L
A
S
S
P
P
S
S
Q
A
P
G
A
L
Site 71
S576
L
A
S
S
P
P
S
S
Q
A
P
G
A
L
Q
Site 72
S613
K
G
G
A
T
T
S
S
P
V
V
A
Q
V
P
Site 73
T636
H
L
P
G
K
P
Q
T
L
A
V
K
R
K
A
Site 74
S645
A
V
K
R
K
A
D
S
E
E
E
R
D
D
V
Site 75
S653
E
E
E
R
D
D
V
S
T
L
G
S
M
L
P
Site 76
T654
E
E
R
D
D
V
S
T
L
G
S
M
L
P
A
Site 77
S657
D
D
V
S
T
L
G
S
M
L
P
A
K
A
S
Site 78
S664
S
M
L
P
A
K
A
S
P
V
A
E
S
P
K
Site 79
S669
K
A
S
P
V
A
E
S
P
K
V
M
D
E
K
Site 80
S677
P
K
V
M
D
E
K
S
S
L
G
E
K
A
E
Site 81
S685
S
L
G
E
K
A
E
S
V
A
N
V
N
A
N
Site 82
T711
A
P
S
V
P
P
P
T
L
A
M
V
S
R
Q
Site 83
S722
V
S
R
Q
M
G
D
S
K
P
P
Q
A
I
V
Site 84
T774
T
G
L
P
T
G
L
T
E
N
Q
S
G
G
P
Site 85
S778
T
G
L
T
E
N
Q
S
G
G
P
L
G
V
D
Site 86
S786
G
G
P
L
G
V
D
S
P
S
A
E
L
D
K
Site 87
S788
P
L
G
V
D
S
P
S
A
E
L
D
K
K
A
Site 88
Y806
K
C
E
Y
C
G
K
Y
A
P
A
E
Q
F
R
Site 89
S815
P
A
E
Q
F
R
G
S
K
R
F
C
S
M
T
Site 90
S820
R
G
S
K
R
F
C
S
M
T
C
A
K
R
Y
Site 91
T822
S
K
R
F
C
S
M
T
C
A
K
R
Y
N
V
Site 92
Y827
S
M
T
C
A
K
R
Y
N
V
S
C
S
H
Q
Site 93
S832
K
R
Y
N
V
S
C
S
H
Q
F
R
L
K
R
Site 94
Y850
K
E
F
Q
E
A
N
Y
A
R
V
R
R
R
G
Site 95
S861
R
R
R
G
P
R
R
S
S
S
D
I
A
R
A
Site 96
S862
R
R
G
P
R
R
S
S
S
D
I
A
R
A
K
Site 97
S863
R
G
P
R
R
S
S
S
D
I
A
R
A
K
I
Site 98
S881
C
H
R
G
Q
E
D
S
S
R
G
S
D
N
S
Site 99
S882
H
R
G
Q
E
D
S
S
R
G
S
D
N
S
S
Site 100
S885
Q
E
D
S
S
R
G
S
D
N
S
S
Y
D
E
Site 101
S888
S
S
R
G
S
D
N
S
S
Y
D
E
A
L
S
Site 102
S889
S
R
G
S
D
N
S
S
Y
D
E
A
L
S
P
Site 103
Y890
R
G
S
D
N
S
S
Y
D
E
A
L
S
P
T
Site 104
S895
S
S
Y
D
E
A
L
S
P
T
S
P
G
P
L
Site 105
S898
D
E
A
L
S
P
T
S
P
G
P
L
S
V
R
Site 106
S903
P
T
S
P
G
P
L
S
V
R
A
G
H
G
E
Site 107
T918
R
D
L
G
N
P
N
T
A
P
P
T
P
E
L
Site 108
T922
N
P
N
T
A
P
P
T
P
E
L
H
G
I
N
Site 109
S934
G
I
N
P
V
F
L
S
S
N
P
S
R
W
S
Site 110
S935
I
N
P
V
F
L
S
S
N
P
S
R
W
S
V
Site 111
S938
V
F
L
S
S
N
P
S
R
W
S
V
E
E
V
Site 112
S941
S
S
N
P
S
R
W
S
V
E
E
V
Y
E
F
Site 113
Y946
R
W
S
V
E
E
V
Y
E
F
I
A
S
L
Q
Site 114
S964
E
I
A
E
E
F
R
S
Q
E
I
D
G
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation