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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIRPA
Full Name:
Tyrosine-protein phosphatase non-receptor type substrate 1
Alias:
Bit; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; CD172a; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MFR; MYD1; MYD-1; MYD-1 antigen; MyD-1 antigen; P84; Protein-tyrosine phosphatase non-receptor type substrate 1; PTPNS1; SHP substrate-1; SHPS-1; SHS1; Signal-regulatory protein alpha; Signal-regulatory protein alpha-1; SIRP; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3
Type:
Cell surface; Receptor, misc.; Adhesion
Mass (Da):
54813
Number AA:
503
UniProt ID:
P78324
International Prot ID:
IPI00656087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S142
S
G
A
G
T
E
L
S
V
R
A
K
P
S
A
Site 2
S403
R
Q
K
K
A
Q
G
S
T
S
S
T
R
L
H
Site 3
S405
K
K
A
Q
G
S
T
S
S
T
R
L
H
E
P
Site 4
S406
K
A
Q
G
S
T
S
S
T
R
L
H
E
P
E
Site 5
T407
A
Q
G
S
T
S
S
T
R
L
H
E
P
E
K
Site 6
T420
E
K
N
A
R
E
I
T
Q
D
T
N
D
I
T
Site 7
T423
A
R
E
I
T
Q
D
T
N
D
I
T
Y
A
D
Site 8
T427
T
Q
D
T
N
D
I
T
Y
A
D
L
N
L
P
Site 9
Y428
Q
D
T
N
D
I
T
Y
A
D
L
N
L
P
K
Site 10
Y452
E
P
N
N
H
T
E
Y
A
S
I
Q
T
S
P
Site 11
S454
N
N
H
T
E
Y
A
S
I
Q
T
S
P
Q
P
Site 12
S458
E
Y
A
S
I
Q
T
S
P
Q
P
A
S
E
D
Site 13
S463
Q
T
S
P
Q
P
A
S
E
D
T
L
T
Y
A
Site 14
T466
P
Q
P
A
S
E
D
T
L
T
Y
A
D
L
D
Site 15
T468
P
A
S
E
D
T
L
T
Y
A
D
L
D
M
V
Site 16
Y469
A
S
E
D
T
L
T
Y
A
D
L
D
M
V
H
Site 17
T480
D
M
V
H
L
N
R
T
P
K
Q
P
A
P
K
Site 18
S491
P
A
P
K
P
E
P
S
F
S
E
Y
A
S
V
Site 19
S493
P
K
P
E
P
S
F
S
E
Y
A
S
V
Q
V
Site 20
Y495
P
E
P
S
F
S
E
Y
A
S
V
Q
V
P
R
Site 21
S497
P
S
F
S
E
Y
A
S
V
Q
V
P
R
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation