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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBB2C
Full Name:
Tubulin beta-2C chain
Alias:
Class IVb beta tubulin; TBB2C; TUBB2; Tubulin beta-2 chain; Tubulin beta-2C; Tubulin, beta 2C; Tubulin, beta, 2C; Tubulin, beta-2c
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
49831
Number AA:
445
UniProt ID:
P68371
International Prot ID:
IPI00007752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005874
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0042288
PhosphoSite+
KinaseNET
Biological Process:
GO:0006928
GO:0007018
GO:0042267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
Site 2
T33
D
E
H
G
I
D
P
T
G
T
Y
H
G
D
S
Site 3
T35
H
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Site 4
Y36
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Q
Site 5
S40
T
G
T
Y
H
G
D
S
D
L
Q
L
E
R
I
Site 6
Y50
Q
L
E
R
I
N
V
Y
Y
N
E
A
T
G
G
Site 7
Y51
L
E
R
I
N
V
Y
Y
N
E
A
T
G
G
K
Site 8
T55
N
V
Y
Y
N
E
A
T
G
G
K
Y
V
P
R
Site 9
Y59
N
E
A
T
G
G
K
Y
V
P
R
A
V
L
V
Site 10
T72
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
Site 11
S75
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Site 12
S78
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
Site 13
S95
D
N
F
V
F
G
Q
S
G
A
G
N
N
W
A
Site 14
Y106
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
Site 15
T107
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
Site 16
S115
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
Site 17
S126
V
V
R
K
E
A
E
S
C
D
C
L
Q
G
F
Site 18
T136
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
Site 19
S138
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
Site 20
T143
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
Site 21
S145
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
Site 22
T149
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
Site 23
S153
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
Site 24
Y159
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
Site 25
T166
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
Site 26
S168
D
R
I
M
N
T
F
S
V
V
P
S
P
K
V
Site 27
S172
N
T
F
S
V
V
P
S
P
K
V
S
D
T
V
Site 28
S176
V
V
P
S
P
K
V
S
D
T
V
V
E
P
Y
Site 29
T178
P
S
P
K
V
S
D
T
V
V
E
P
Y
N
A
Site 30
Y183
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Site 31
S188
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
Site 32
T196
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
Site 33
T199
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
Site 34
Y200
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Site 35
Y208
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
Site 36
T218
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
Site 37
T219
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
Site 38
T221
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
Site 39
Y222
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
Site 40
S230
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
Site 41
S234
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
Site 42
T274
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
Site 43
S275
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
R
Site 44
S278
A
P
L
T
S
R
G
S
Q
Q
Y
R
A
L
T
Site 45
Y281
T
S
R
G
S
Q
Q
Y
R
A
L
T
V
P
E
Site 46
T285
S
Q
Q
Y
R
A
L
T
V
P
E
L
T
Q
Q
Site 47
T290
A
L
T
V
P
E
L
T
Q
Q
M
F
D
A
K
Site 48
Y310
C
D
P
R
H
G
R
Y
L
T
V
A
A
V
F
Site 49
T312
P
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
Site 50
S322
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
Site 51
S338
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
Site 52
S339
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
Site 53
Y340
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
Site 54
S364
P
P
R
G
L
K
M
S
A
T
F
I
G
N
S
Site 55
T366
R
G
L
K
M
S
A
T
F
I
G
N
S
T
A
Site 56
S382
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
Site 57
Y398
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
Site 58
Y422
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
Site 59
Y425
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
E
E
Site 60
T429
Y
Q
Q
Y
Q
D
A
T
A
E
E
E
G
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation