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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R2A
Full Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alias:
PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, B-alpha isoform
Type:
Mass (Da):
51674
Number AA:
447
UniProt ID:
P63151
International Prot ID:
IPI00332511
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000159
GO:0008287
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004721
GO:0004722
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
S
T
V
E
F
N
H
S
G
E
L
L
A
T
G
Site 2
T45
H
S
G
E
L
L
A
T
G
D
K
G
G
R
V
Site 3
Y71
Q
S
H
S
R
G
E
Y
N
V
Y
S
T
F
Q
Site 4
Y74
S
R
G
E
Y
N
V
Y
S
T
F
Q
S
H
E
Site 5
Y86
S
H
E
P
E
F
D
Y
L
K
S
L
E
I
E
Site 6
S89
P
E
F
D
Y
L
K
S
L
E
I
E
E
K
I
Site 7
S113
N
A
A
Q
F
L
L
S
T
N
D
K
T
I
K
Site 8
T118
L
L
S
T
N
D
K
T
I
K
L
W
K
I
S
Site 9
S125
T
I
K
L
W
K
I
S
E
R
D
K
R
P
E
Site 10
Y143
L
K
E
E
D
G
R
Y
R
D
P
T
T
V
T
Site 11
T147
D
G
R
Y
R
D
P
T
T
V
T
T
L
R
V
Site 12
T148
G
R
Y
R
D
P
T
T
V
T
T
L
R
V
P
Site 13
T151
R
D
P
T
T
V
T
T
L
R
V
P
V
F
R
Site 14
S167
M
D
L
M
V
E
A
S
P
R
R
I
F
A
N
Site 15
Y189
S
I
S
I
N
S
D
Y
E
T
Y
L
S
A
D
Site 16
T191
S
I
N
S
D
Y
E
T
Y
L
S
A
D
D
L
Site 17
S194
S
D
Y
E
T
Y
L
S
A
D
D
L
R
I
N
Site 18
S211
H
L
E
I
T
D
R
S
F
N
I
V
D
I
K
Site 19
T241
F
H
P
N
S
C
N
T
F
V
Y
S
S
S
K
Site 20
Y244
N
S
C
N
T
F
V
Y
S
S
S
K
G
T
I
Site 21
S245
S
C
N
T
F
V
Y
S
S
S
K
G
T
I
R
Site 22
S247
N
T
F
V
Y
S
S
S
K
G
T
I
R
L
C
Site 23
T250
V
Y
S
S
S
K
G
T
I
R
L
C
D
M
R
Site 24
S259
R
L
C
D
M
R
A
S
A
L
C
D
R
H
S
Site 25
S266
S
A
L
C
D
R
H
S
K
L
F
E
E
P
E
Site 26
S276
F
E
E
P
E
D
P
S
N
R
S
F
F
S
E
Site 27
S279
P
E
D
P
S
N
R
S
F
F
S
E
I
I
S
Site 28
S282
P
S
N
R
S
F
F
S
E
I
I
S
S
I
S
Site 29
S289
S
E
I
I
S
S
I
S
D
V
K
F
S
H
S
Site 30
S296
S
D
V
K
F
S
H
S
G
R
Y
M
M
T
R
Site 31
Y305
R
Y
M
M
T
R
D
Y
L
S
V
K
I
W
D
Site 32
Y323
E
N
R
P
V
E
T
Y
Q
V
H
E
Y
L
R
Site 33
Y328
E
T
Y
Q
V
H
E
Y
L
R
S
K
L
C
S
Site 34
S331
Q
V
H
E
Y
L
R
S
K
L
C
S
L
Y
E
Site 35
S335
Y
L
R
S
K
L
C
S
L
Y
E
N
D
C
I
Site 36
Y337
R
S
K
L
C
S
L
Y
E
N
D
C
I
F
D
Site 37
S355
C
C
W
N
G
S
D
S
V
V
M
T
G
S
Y
Site 38
T359
G
S
D
S
V
V
M
T
G
S
Y
N
N
F
F
Site 39
T373
F
R
M
F
D
R
N
T
K
R
D
I
T
L
E
Site 40
T378
R
N
T
K
R
D
I
T
L
E
A
S
R
E
N
Site 41
S382
R
D
I
T
L
E
A
S
R
E
N
N
K
P
R
Site 42
T390
R
E
N
N
K
P
R
T
V
L
K
P
R
K
V
Site 43
S400
K
P
R
K
V
C
A
S
G
K
R
K
K
D
E
Site 44
S409
K
R
K
K
D
E
I
S
V
D
S
L
D
F
N
Site 45
S412
K
D
E
I
S
V
D
S
L
D
F
N
K
K
I
Site 46
Y440
V
A
T
T
N
N
L
Y
I
F
Q
D
K
V
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation