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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COPS2
Full Name:
COP9 signalosome complex subunit 2
Alias:
ALIEN; COP9 constitutive photomorphogenic homologue subunit 2; COP9 constitutive photomorphogenic homologue subunit 2 (Arabidopsis); CSN2; JAB1-containing signalosome subunit 2; SGN2; Signalosome subunit 2; Thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TRIP15
Type:
Transcription protein, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
51597
Number AA:
443
UniProt ID:
P61201
International Prot ID:
IPI00018813
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008180
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
M
C
D
D
E
E
D
Y
D
L
E
Y
S
E
D
Site 2
Y20
E
E
D
Y
D
L
E
Y
S
E
D
S
N
S
E
Site 3
S21
E
D
Y
D
L
E
Y
S
E
D
S
N
S
E
P
Site 4
S24
D
L
E
Y
S
E
D
S
N
S
E
P
N
V
D
Site 5
S26
E
Y
S
E
D
S
N
S
E
P
N
V
D
L
E
Site 6
Y37
V
D
L
E
N
Q
Y
Y
N
S
K
A
L
K
E
Site 7
S52
D
D
P
K
A
A
L
S
S
F
Q
K
V
L
E
Site 8
S53
D
P
K
A
A
L
S
S
F
Q
K
V
L
E
L
Site 9
Y92
F
P
E
M
M
N
R
Y
K
Q
L
L
T
Y
I
Site 10
T97
N
R
Y
K
Q
L
L
T
Y
I
R
S
A
V
T
Site 11
Y98
R
Y
K
Q
L
L
T
Y
I
R
S
A
V
T
R
Site 12
S101
Q
L
L
T
Y
I
R
S
A
V
T
R
N
Y
S
Site 13
T104
T
Y
I
R
S
A
V
T
R
N
Y
S
E
K
S
Site 14
Y107
R
S
A
V
T
R
N
Y
S
E
K
S
I
N
S
Site 15
S108
S
A
V
T
R
N
Y
S
E
K
S
I
N
S
I
Site 16
S111
T
R
N
Y
S
E
K
S
I
N
S
I
L
D
Y
Site 17
Y118
S
I
N
S
I
L
D
Y
I
S
T
S
K
Q
M
Site 18
S120
N
S
I
L
D
Y
I
S
T
S
K
Q
M
D
L
Site 19
T134
L
L
Q
E
F
Y
E
T
T
L
E
A
L
K
D
Site 20
T151
N
D
R
L
W
F
K
T
N
T
K
L
G
K
L
Site 21
T153
R
L
W
F
K
T
N
T
K
L
G
K
L
Y
L
Site 22
Y159
N
T
K
L
G
K
L
Y
L
E
R
E
E
Y
G
Site 23
Y165
L
Y
L
E
R
E
E
Y
G
K
L
Q
K
I
L
Site 24
S178
I
L
R
Q
L
H
Q
S
C
Q
T
D
D
G
E
Site 25
Y205
Y
A
L
E
I
Q
M
Y
T
A
Q
K
N
N
K
Site 26
Y218
N
K
K
L
K
A
L
Y
E
Q
S
L
H
I
K
Site 27
S226
E
Q
S
L
H
I
K
S
A
I
P
H
P
L
I
Site 28
T256
G
E
F
E
K
A
H
T
D
F
F
E
A
F
K
Site 29
Y265
F
F
E
A
F
K
N
Y
D
E
S
G
S
P
R
Site 30
S268
A
F
K
N
Y
D
E
S
G
S
P
R
R
T
T
Site 31
S270
K
N
Y
D
E
S
G
S
P
R
R
T
T
C
L
Site 32
T274
E
S
G
S
P
R
R
T
T
C
L
K
Y
L
V
Site 33
T275
S
G
S
P
R
R
T
T
C
L
K
Y
L
V
L
Site 34
Y279
R
R
T
T
C
L
K
Y
L
V
L
A
N
M
L
Site 35
S296
S
G
I
N
P
F
D
S
Q
E
A
K
P
Y
K
Site 36
Y302
D
S
Q
E
A
K
P
Y
K
N
D
P
E
I
L
Site 37
T324
A
Y
Q
N
N
D
I
T
E
F
E
K
I
L
K
Site 38
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Site 39
T422
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
N
Site 40
S433
K
W
T
N
Q
L
N
S
L
N
Q
A
V
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation