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Updated November 2019
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Protein Info
Short Name:
ZC3H6
Full Name:
Zinc finger CCCH domain-containing protein 6
Alias:
FLJ41410; FLJ45877; KIAA2035; ZC3HDC6; zinc finger CCCH-type containing 6; zinc finger CCCH-type domain containing protein 6
Type:
Unknown function
Mass (Da):
131671
Number AA:
1189
UniProt ID:
P61129
International Prot ID:
IPI00410656
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y46
K
Q
K
N
E
K
A
Y
R
K
S
R
K
K
H
Site 2
S49
N
E
K
A
Y
R
K
S
R
K
K
H
K
K
E
Site 3
S62
K
E
R
E
K
K
K
S
K
R
R
K
R
E
K
Site 4
S74
R
E
K
H
K
H
N
S
P
S
S
D
D
S
S
Site 5
S76
K
H
K
H
N
S
P
S
S
D
D
S
S
D
Y
Site 6
S77
H
K
H
N
S
P
S
S
D
D
S
S
D
Y
S
Site 7
S80
N
S
P
S
S
D
D
S
S
D
Y
S
L
D
S
Site 8
S81
S
P
S
S
D
D
S
S
D
Y
S
L
D
S
D
Site 9
Y83
S
S
D
D
S
S
D
Y
S
L
D
S
D
V
E
Site 10
S84
S
D
D
S
S
D
Y
S
L
D
S
D
V
E
H
Site 11
S87
S
S
D
Y
S
L
D
S
D
V
E
H
T
E
S
Site 12
S94
S
D
V
E
H
T
E
S
S
H
K
K
R
T
G
Site 13
Y106
R
T
G
F
Y
R
D
Y
D
I
P
F
T
Q
R
Site 14
T111
R
D
Y
D
I
P
F
T
Q
R
G
H
I
S
G
Site 15
S117
F
T
Q
R
G
H
I
S
G
S
Y
I
T
S
K
Site 16
S119
Q
R
G
H
I
S
G
S
Y
I
T
S
K
K
G
Site 17
Y120
R
G
H
I
S
G
S
Y
I
T
S
K
K
G
Q
Site 18
S123
I
S
G
S
Y
I
T
S
K
K
G
Q
H
N
K
Site 19
S134
Q
H
N
K
K
F
K
S
K
E
Y
D
E
Y
S
Site 20
Y137
K
K
F
K
S
K
E
Y
D
E
Y
S
T
Y
S
Site 21
Y140
K
S
K
E
Y
D
E
Y
S
T
Y
S
D
D
N
Site 22
S141
S
K
E
Y
D
E
Y
S
T
Y
S
D
D
N
F
Site 23
Y143
E
Y
D
E
Y
S
T
Y
S
D
D
N
F
G
N
Site 24
Y151
S
D
D
N
F
G
N
Y
S
D
D
N
F
G
N
Site 25
Y159
S
D
D
N
F
G
N
Y
G
Q
E
T
E
E
D
Site 26
T163
F
G
N
Y
G
Q
E
T
E
E
D
F
A
N
Q
Site 27
T180
Q
Y
R
Q
A
K
E
T
S
N
I
A
L
G
S
Site 28
S187
T
S
N
I
A
L
G
S
S
F
S
K
E
S
G
Site 29
S188
S
N
I
A
L
G
S
S
F
S
K
E
S
G
K
Site 30
S190
I
A
L
G
S
S
F
S
K
E
S
G
K
K
Q
Site 31
S212
G
I
E
Q
R
V
K
S
F
N
V
G
R
G
R
Site 32
S242
N
K
G
P
N
V
F
S
V
S
D
D
F
Q
E
Site 33
S244
G
P
N
V
F
S
V
S
D
D
F
Q
E
Y
N
Site 34
Y250
V
S
D
D
F
Q
E
Y
N
K
P
G
K
K
W
Site 35
T269
Q
E
F
I
N
Q
H
T
V
E
H
K
G
K
Q
Site 36
Y280
K
G
K
Q
I
C
K
Y
F
L
E
G
R
C
I
Site 37
Y310
R
K
E
I
C
K
F
Y
L
Q
G
Y
C
T
K
Site 38
T353
K
F
S
H
D
D
L
T
K
E
T
K
K
L
L
Site 39
T366
L
L
D
K
V
L
N
T
D
E
E
L
I
N
E
Site 40
T387
E
L
R
K
R
G
I
T
P
L
P
K
P
P
P
Site 41
S409
P
P
E
H
F
P
F
S
D
P
E
D
D
F
Q
Site 42
T417
D
P
E
D
D
F
Q
T
D
F
S
D
D
F
R
Site 43
S420
D
D
F
Q
T
D
F
S
D
D
F
R
K
I
P
Site 44
Y452
G
R
K
P
P
A
F
Y
T
S
A
S
P
P
G
Site 45
T453
R
K
P
P
A
F
Y
T
S
A
S
P
P
G
P
Site 46
S454
K
P
P
A
F
Y
T
S
A
S
P
P
G
P
Q
Site 47
S456
P
A
F
Y
T
S
A
S
P
P
G
P
Q
F
Q
Site 48
S465
P
G
P
Q
F
Q
G
S
S
P
H
P
Q
H
I
Site 49
S466
G
P
Q
F
Q
G
S
S
P
H
P
Q
H
I
Y
Site 50
Y473
S
P
H
P
Q
H
I
Y
S
S
G
S
S
P
G
Site 51
S474
P
H
P
Q
H
I
Y
S
S
G
S
S
P
G
P
Site 52
S475
H
P
Q
H
I
Y
S
S
G
S
S
P
G
P
G
Site 53
S477
Q
H
I
Y
S
S
G
S
S
P
G
P
G
P
N
Site 54
S478
H
I
Y
S
S
G
S
S
P
G
P
G
P
N
M
Site 55
S486
P
G
P
G
P
N
M
S
Q
G
H
S
S
P
V
Site 56
S490
P
N
M
S
Q
G
H
S
S
P
V
M
H
P
G
Site 57
S491
N
M
S
Q
G
H
S
S
P
V
M
H
P
G
S
Site 58
S498
S
P
V
M
H
P
G
S
P
G
H
H
P
C
A
Site 59
S515
P
G
L
P
V
P
Q
S
P
P
L
P
P
G
P
Site 60
T543
V
Q
P
D
T
S
L
T
P
P
S
M
G
G
A
Site 61
S546
D
T
S
L
T
P
P
S
M
G
G
A
Y
H
S
Site 62
Y551
P
P
S
M
G
G
A
Y
H
S
P
G
F
P
G
Site 63
S553
S
M
G
G
A
Y
H
S
P
G
F
P
G
H
V
Site 64
S570
V
P
R
E
N
H
C
S
P
G
S
S
Y
Q
Q
Site 65
S573
E
N
H
C
S
P
G
S
S
Y
Q
Q
S
P
G
Site 66
S574
N
H
C
S
P
G
S
S
Y
Q
Q
S
P
G
E
Site 67
Y575
H
C
S
P
G
S
S
Y
Q
Q
S
P
G
E
M
Site 68
S578
P
G
S
S
Y
Q
Q
S
P
G
E
M
Q
L
N
Site 69
T586
P
G
E
M
Q
L
N
T
N
Y
E
S
L
Q
N
Site 70
Y588
E
M
Q
L
N
T
N
Y
E
S
L
Q
N
P
A
Site 71
Y601
P
A
E
F
Y
D
N
Y
Y
A
Q
H
S
I
H
Site 72
Y602
A
E
F
Y
D
N
Y
Y
A
Q
H
S
I
H
N
Site 73
S636
Q
P
P
V
V
Q
D
S
P
N
H
G
S
G
S
Site 74
S641
Q
D
S
P
N
H
G
S
G
S
D
G
S
S
T
Site 75
S643
S
P
N
H
G
S
G
S
D
G
S
S
T
R
T
Site 76
S646
H
G
S
G
S
D
G
S
S
T
R
T
G
H
G
Site 77
S647
G
S
G
S
D
G
S
S
T
R
T
G
H
G
P
Site 78
T648
S
G
S
D
G
S
S
T
R
T
G
H
G
P
L
Site 79
T650
S
D
G
S
S
T
R
T
G
H
G
P
L
P
V
Site 80
T673
R
A
L
F
V
R
L
T
Q
R
Y
Q
E
D
E
Site 81
Y676
F
V
R
L
T
Q
R
Y
Q
E
D
E
E
Q
T
Site 82
S684
Q
E
D
E
E
Q
T
S
T
Q
P
H
R
A
P
Site 83
T685
E
D
E
E
Q
T
S
T
Q
P
H
R
A
P
S
Site 84
S692
T
Q
P
H
R
A
P
S
K
E
E
D
D
T
V
Site 85
T698
P
S
K
E
E
D
D
T
V
N
W
Y
S
S
S
Site 86
Y702
E
D
D
T
V
N
W
Y
S
S
S
E
E
E
E
Site 87
S703
D
D
T
V
N
W
Y
S
S
S
E
E
E
E
G
Site 88
S704
D
T
V
N
W
Y
S
S
S
E
E
E
E
G
S
Site 89
S705
T
V
N
W
Y
S
S
S
E
E
E
E
G
S
S
Site 90
S711
S
S
E
E
E
E
G
S
S
V
K
S
I
L
K
Site 91
S712
S
E
E
E
E
G
S
S
V
K
S
I
L
K
T
Site 92
S715
E
E
G
S
S
V
K
S
I
L
K
T
L
Q
K
Site 93
T719
S
V
K
S
I
L
K
T
L
Q
K
Q
T
E
T
Site 94
S734
L
R
N
Q
Q
Q
P
S
T
E
L
S
T
P
T
Site 95
T735
R
N
Q
Q
Q
P
S
T
E
L
S
T
P
T
D
Site 96
S738
Q
Q
P
S
T
E
L
S
T
P
T
D
P
R
L
Site 97
T739
Q
P
S
T
E
L
S
T
P
T
D
P
R
L
A
Site 98
S750
P
R
L
A
K
E
K
S
K
G
N
Q
V
V
D
Site 99
T762
V
V
D
P
R
L
R
T
I
P
R
Q
D
I
R
Site 100
S772
R
Q
D
I
R
K
P
S
E
S
A
P
L
D
L
Site 101
S774
D
I
R
K
P
S
E
S
A
P
L
D
L
R
L
Site 102
S793
R
K
L
R
G
N
G
S
G
H
I
G
S
S
V
Site 103
S798
N
G
S
G
H
I
G
S
S
V
G
G
A
K
F
Site 104
S799
G
S
G
H
I
G
S
S
V
G
G
A
K
F
D
Site 105
T828
G
D
D
D
D
E
D
T
E
R
E
L
R
E
K
Site 106
S854
I
M
L
Q
D
P
R
S
Q
L
R
Q
F
S
H
Site 107
S860
R
S
Q
L
R
Q
F
S
H
I
K
M
D
I
T
Site 108
T867
S
H
I
K
M
D
I
T
L
T
K
P
N
F
A
Site 109
T869
I
K
M
D
I
T
L
T
K
P
N
F
A
K
H
Site 110
S896
L
P
K
P
D
P
V
S
S
I
N
L
P
L
P
Site 111
S897
P
K
P
D
P
V
S
S
I
N
L
P
L
P
P
Site 112
S919
N
R
L
W
N
T
K
S
D
L
H
Q
N
T
V
Site 113
T925
K
S
D
L
H
Q
N
T
V
S
I
D
P
K
L
Site 114
S927
D
L
H
Q
N
T
V
S
I
D
P
K
L
A
A
Site 115
Y946
N
T
T
N
R
E
G
Y
L
E
Q
F
G
D
S
Site 116
T979
R
L
H
R
L
P
N
T
E
S
H
Q
V
V
M
Site 117
S981
H
R
L
P
N
T
E
S
H
Q
V
V
M
K
D
Site 118
S989
H
Q
V
V
M
K
D
S
H
A
S
K
G
A
P
Site 119
S1001
G
A
P
H
L
P
R
S
N
P
G
S
S
Q
P
Site 120
S1005
L
P
R
S
N
P
G
S
S
Q
P
S
G
A
G
Site 121
S1006
P
R
S
N
P
G
S
S
Q
P
S
G
A
G
T
Site 122
S1009
N
P
G
S
S
Q
P
S
G
A
G
T
S
N
S
Site 123
T1013
S
Q
P
S
G
A
G
T
S
N
S
G
S
G
A
Site 124
S1014
Q
P
S
G
A
G
T
S
N
S
G
S
G
A
L
Site 125
S1016
S
G
A
G
T
S
N
S
G
S
G
A
L
P
P
Site 126
S1018
A
G
T
S
N
S
G
S
G
A
L
P
P
Y
A
Site 127
Y1024
G
S
G
A
L
P
P
Y
A
P
K
L
S
S
S
Site 128
S1029
P
P
Y
A
P
K
L
S
S
S
A
G
L
P
L
Site 129
S1030
P
Y
A
P
K
L
S
S
S
A
G
L
P
L
G
Site 130
S1031
Y
A
P
K
L
S
S
S
A
G
L
P
L
G
T
Site 131
Y1049
V
L
S
G
I
S
L
Y
D
P
R
D
H
G
S
Site 132
S1056
Y
D
P
R
D
H
G
S
S
S
T
S
E
L
A
Site 133
S1057
D
P
R
D
H
G
S
S
S
T
S
E
L
A
T
Site 134
S1058
P
R
D
H
G
S
S
S
T
S
E
L
A
T
A
Site 135
S1060
D
H
G
S
S
S
T
S
E
L
A
T
A
S
S
Site 136
T1064
S
S
T
S
E
L
A
T
A
S
S
G
E
N
S
Site 137
S1067
S
E
L
A
T
A
S
S
G
E
N
S
K
N
Q
Site 138
S1071
T
A
S
S
G
E
N
S
K
N
Q
K
K
S
G
Site 139
S1077
N
S
K
N
Q
K
K
S
G
G
L
K
S
S
D
Site 140
S1082
K
K
S
G
G
L
K
S
S
D
K
T
E
P
S
Site 141
S1083
K
S
G
G
L
K
S
S
D
K
T
E
P
S
P
Site 142
T1086
G
L
K
S
S
D
K
T
E
P
S
P
G
E
A
Site 143
S1089
S
S
D
K
T
E
P
S
P
G
E
A
I
L
P
Site 144
S1120
P
Q
A
D
V
P
R
S
S
G
K
V
Q
V
P
Site 145
S1121
Q
A
D
V
P
R
S
S
G
K
V
Q
V
P
A
Site 146
Y1145
T
G
L
I
R
P
Q
Y
S
D
P
R
Q
A
R
Site 147
S1146
G
L
I
R
P
Q
Y
S
D
P
R
Q
A
R
Q
Site 148
S1158
A
R
Q
P
G
Q
G
S
P
T
P
D
N
D
P
Site 149
T1160
Q
P
G
Q
G
S
P
T
P
D
N
D
P
G
R
Site 150
T1169
D
N
D
P
G
R
E
T
D
D
K
S
L
K
E
Site 151
S1173
G
R
E
T
D
D
K
S
L
K
E
V
F
K
T
Site 152
T1180
S
L
K
E
V
F
K
T
F
D
P
T
A
S
P
Site 153
S1186
K
T
F
D
P
T
A
S
P
F
C
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation