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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF3E
Full Name:
Eukaryotic translation initiation factor 3 subunit E
Alias:
EIF-3 p48; EIF3S6; Eukaryotic translation initiation factor 3 subunit 6; Viral integration site protein INT-6 homologue
Type:
Translation protein, initiation complex
Mass (Da):
52221
Number AA:
445
UniProt ID:
P60228
International Prot ID:
IPI00013068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0047485
GO:0003743
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0045947
GO:0000184
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
Q
G
K
L
D
L
L
S
D
T
N
M
V
D
F
Site 2
Y58
V
D
F
A
M
D
V
Y
K
N
L
Y
S
D
D
Site 3
Y62
M
D
V
Y
K
N
L
Y
S
D
D
I
P
H
A
Site 4
S63
D
V
Y
K
N
L
Y
S
D
D
I
P
H
A
L
Site 5
T76
A
L
R
E
K
R
T
T
V
V
A
Q
L
K
Q
Site 6
T100
K
M
F
E
D
P
E
T
T
R
Q
M
Q
S
T
Site 7
S106
E
T
T
R
Q
M
Q
S
T
R
D
G
R
M
L
Site 8
T107
T
T
R
Q
M
Q
S
T
R
D
G
R
M
L
F
Site 9
Y116
D
G
R
M
L
F
D
Y
L
A
D
K
H
G
F
Site 10
Y127
K
H
G
F
R
Q
E
Y
L
D
T
L
Y
R
Y
Site 11
T130
F
R
Q
E
Y
L
D
T
L
Y
R
Y
A
K
F
Site 12
Y132
Q
E
Y
L
D
T
L
Y
R
Y
A
K
F
Q
Y
Site 13
Y139
Y
R
Y
A
K
F
Q
Y
E
C
G
N
Y
S
G
Site 14
Y144
F
Q
Y
E
C
G
N
Y
S
G
A
A
E
Y
L
Site 15
T161
F
R
V
L
V
P
A
T
D
R
N
A
L
S
S
Site 16
S168
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Site 17
T190
D
A
A
M
E
D
L
T
R
L
K
E
T
I
D
Site 18
S200
K
E
T
I
D
N
N
S
V
S
S
P
L
Q
S
Site 19
S202
T
I
D
N
N
S
V
S
S
P
L
Q
S
L
Q
Site 20
S203
I
D
N
N
S
V
S
S
P
L
Q
S
L
Q
Q
Site 21
S207
S
V
S
S
P
L
Q
S
L
Q
Q
R
T
W
L
Site 22
S285
V
K
V
I
Q
Q
E
S
Y
T
Y
K
D
P
I
Site 23
Y288
I
Q
Q
E
S
Y
T
Y
K
D
P
I
T
E
F
Site 24
S317
K
K
L
R
E
C
E
S
V
L
V
N
D
F
F
Site 25
T363
L
A
D
K
L
N
M
T
P
E
E
A
E
R
W
Site 26
S386
R
L
D
A
K
I
D
S
K
L
G
H
V
V
M
Site 27
S399
V
M
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
Site 28
Y401
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Site 29
T408
Y
Q
Q
V
I
E
K
T
K
S
L
S
F
R
S
Site 30
S410
Q
V
I
E
K
T
K
S
L
S
F
R
S
Q
M
Site 31
S412
I
E
K
T
K
S
L
S
F
R
S
Q
M
L
A
Site 32
S430
E
K
K
L
N
Q
N
S
R
S
E
A
P
N
W
Site 33
S432
K
L
N
Q
N
S
R
S
E
A
P
N
W
A
T
Site 34
T439
S
E
A
P
N
W
A
T
Q
D
S
G
F
Y
_
Site 35
S442
P
N
W
A
T
Q
D
S
G
F
Y
_
_
_
_
Site 36
Y445
A
T
Q
D
S
G
F
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation