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Updated November 2019
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Protein Info
Short Name:
ADAMTS20
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 20
Alias:
Type:
Mass (Da):
214721
Number AA:
1910
UniProt ID:
P59510
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
F
G
E
V
F
P
Q
S
H
H
F
S
R
Q
K
Site 2
S62
F
P
Q
S
H
H
F
S
R
Q
K
R
S
S
E
Site 3
S68
F
S
R
Q
K
R
S
S
E
A
L
E
P
M
P
Site 4
T78
L
E
P
M
P
F
R
T
H
Y
R
F
T
A
Y
Site 5
Y80
P
M
P
F
R
T
H
Y
R
F
T
A
Y
G
Q
Site 6
T111
Y
T
E
V
H
L
G
T
P
E
R
G
A
W
E
Site 7
S119
P
E
R
G
A
W
E
S
D
A
G
P
S
D
L
Site 8
Y131
S
D
L
R
H
C
F
Y
R
G
Q
V
N
S
Q
Site 9
S137
F
Y
R
G
Q
V
N
S
Q
E
D
Y
K
A
V
Site 10
Y141
Q
V
N
S
Q
E
D
Y
K
A
V
V
S
L
C
Site 11
T154
L
C
G
G
L
T
G
T
F
K
G
Q
N
G
E
Site 12
Y162
F
K
G
Q
N
G
E
Y
F
L
E
P
I
M
K
Site 13
S193
Y
R
Q
D
L
N
N
S
F
L
Q
T
L
K
Y
Site 14
T197
L
N
N
S
F
L
Q
T
L
K
Y
C
S
V
S
Site 15
Y200
S
F
L
Q
T
L
K
Y
C
S
V
S
E
S
Q
Site 16
S202
L
Q
T
L
K
Y
C
S
V
S
E
S
Q
I
K
Site 17
S206
K
Y
C
S
V
S
E
S
Q
I
K
E
T
S
L
Site 18
T211
S
E
S
Q
I
K
E
T
S
L
P
F
H
T
Y
Site 19
S212
E
S
Q
I
K
E
T
S
L
P
F
H
T
Y
S
Site 20
T236
K
E
R
V
L
G
H
T
S
K
N
V
P
L
K
Site 21
S249
L
K
D
E
R
R
H
S
R
K
K
R
L
I
S
Site 22
S256
S
R
K
K
R
L
I
S
Y
P
R
Y
I
E
I
Site 23
Y257
R
K
K
R
L
I
S
Y
P
R
Y
I
E
I
M
Site 24
S273
T
A
D
A
K
V
V
S
A
H
G
S
N
L
Q
Site 25
S277
K
V
V
S
A
H
G
S
N
L
Q
N
Y
I
L
Site 26
S349
D
L
D
D
V
H
P
S
H
H
D
T
A
V
L
Site 27
T353
V
H
P
S
H
H
D
T
A
V
L
I
T
R
E
Site 28
T408
I
A
H
E
L
G
H
T
L
G
V
Q
H
D
D
Site 29
Y427
K
E
M
K
V
T
K
Y
H
V
M
A
P
A
L
Site 30
Y450
W
S
N
C
S
R
K
Y
V
T
E
F
L
D
T
Site 31
Y459
T
E
F
L
D
T
G
Y
G
E
C
L
L
D
K
Site 32
Y472
D
K
P
D
E
E
I
Y
N
L
P
S
E
L
P
Site 33
S476
E
E
I
Y
N
L
P
S
E
L
P
G
S
R
Y
Site 34
S481
L
P
S
E
L
P
G
S
R
Y
D
G
N
K
Q
Site 35
Y483
S
E
L
P
G
S
R
Y
D
G
N
K
Q
C
E
Site 36
T523
K
L
H
K
G
C
F
T
Q
H
V
P
P
A
D
Site 37
T532
H
V
P
P
A
D
G
T
D
C
G
P
G
M
H
Site 38
S567
G
P
W
E
P
Y
S
S
C
S
R
T
C
G
G
Site 39
T571
P
Y
S
S
C
S
R
T
C
G
G
G
I
E
S
Site 40
S578
T
C
G
G
G
I
E
S
A
T
R
R
C
N
R
Site 41
T580
G
G
G
I
E
S
A
T
R
R
C
N
R
P
E
Site 42
Y594
E
P
R
N
G
G
N
Y
C
V
G
R
R
M
K
Site 43
S604
G
R
R
M
K
F
R
S
C
N
T
D
S
C
P
Site 44
S609
F
R
S
C
N
T
D
S
C
P
K
G
T
Q
D
Site 45
S623
D
F
R
E
K
Q
C
S
D
F
N
G
K
H
L
Site 46
S633
N
G
K
H
L
D
I
S
G
I
P
S
N
V
R
Site 47
S637
L
D
I
S
G
I
P
S
N
V
R
W
L
P
R
Site 48
Y645
N
V
R
W
L
P
R
Y
S
G
I
G
T
K
D
Site 49
S646
V
R
W
L
P
R
Y
S
G
I
G
T
K
D
R
Site 50
T650
P
R
Y
S
G
I
G
T
K
D
R
C
K
L
Y
Site 51
Y657
T
K
D
R
C
K
L
Y
C
Q
V
A
G
T
N
Site 52
T677
K
D
M
V
E
D
G
T
P
C
G
T
E
T
H
Site 53
S718
G
V
C
G
G
D
N
S
S
C
K
T
I
T
G
Site 54
T722
G
D
N
S
S
C
K
T
I
T
G
V
F
N
S
Site 55
Y734
F
N
S
S
H
Y
G
Y
N
V
V
V
K
I
P
Site 56
Y752
T
N
V
D
I
R
Q
Y
S
Y
S
G
Q
P
D
Site 57
S753
N
V
D
I
R
Q
Y
S
Y
S
G
Q
P
D
D
Site 58
S755
D
I
R
Q
Y
S
Y
S
G
Q
P
D
D
S
Y
Site 59
S761
Y
S
G
Q
P
D
D
S
Y
L
A
L
S
D
A
Site 60
Y762
S
G
Q
P
D
D
S
Y
L
A
L
S
D
A
E
Site 61
S766
D
D
S
Y
L
A
L
S
D
A
E
G
N
F
L
Site 62
S781
F
N
G
N
F
L
L
S
T
S
K
K
E
I
N
Site 63
T794
I
N
V
Q
G
T
R
T
V
I
E
Y
S
G
S
Site 64
Y798
G
T
R
T
V
I
E
Y
S
G
S
N
N
A
V
Site 65
S801
T
V
I
E
Y
S
G
S
N
N
A
V
E
R
I
Site 66
S810
N
A
V
E
R
I
N
S
T
N
R
Q
E
K
E
Site 67
Y835
L
Y
N
P
D
V
H
Y
S
F
N
I
P
L
E
Site 68
T872
G
L
Q
R
R
N
I
T
C
I
H
K
S
D
H
Site 69
S880
C
I
H
K
S
D
H
S
V
V
S
D
K
E
C
Site 70
S883
K
S
D
H
S
V
V
S
D
K
E
C
D
H
L
Site 71
S918
I
G
K
S
E
C
S
S
Q
C
G
Q
G
Y
R
Site 72
Y924
S
S
Q
C
G
Q
G
Y
R
T
L
D
I
H
C
Site 73
Y934
L
D
I
H
C
M
K
Y
S
I
H
E
G
Q
T
Site 74
Y948
T
V
Q
V
D
D
H
Y
C
G
D
Q
L
K
P
Site 75
T957
G
D
Q
L
K
P
P
T
Q
E
L
C
H
G
N
Site 76
S979
Y
S
E
W
S
Q
C
S
R
S
C
G
G
G
E
Site 77
S981
E
W
S
Q
C
S
R
S
C
G
G
G
E
R
S
Site 78
S988
S
C
G
G
G
E
R
S
R
E
S
Y
C
M
N
Site 79
S991
G
G
E
R
S
R
E
S
Y
C
M
N
N
F
G
Site 80
Y992
G
E
R
S
R
E
S
Y
C
M
N
N
F
G
H
Site 81
T1013
C
Q
E
L
S
R
V
T
R
E
N
C
N
E
F
Site 82
T1036
E
W
S
E
C
L
V
T
C
G
K
G
T
K
Q
Site 83
S1056
Q
L
N
V
D
H
L
S
D
G
F
C
N
S
S
Site 84
S1062
L
S
D
G
F
C
N
S
S
T
K
P
E
S
L
Site 85
S1063
S
D
G
F
C
N
S
S
T
K
P
E
S
L
S
Site 86
T1064
D
G
F
C
N
S
S
T
K
P
E
S
L
S
P
Site 87
S1068
N
S
S
T
K
P
E
S
L
S
P
C
E
L
H
Site 88
S1070
S
T
K
P
E
S
L
S
P
C
E
L
H
T
C
Site 89
T1115
A
S
A
V
L
E
D
T
E
C
H
E
A
S
R
Site 90
S1124
C
H
E
A
S
R
P
S
D
R
Q
S
C
V
L
Site 91
S1128
S
R
P
S
D
R
Q
S
C
V
L
T
P
C
S
Site 92
T1132
D
R
Q
S
C
V
L
T
P
C
S
F
I
S
K
Site 93
S1167
S
W
T
P
C
S
V
S
C
G
R
G
T
Q
A
Site 94
T1172
S
V
S
C
G
R
G
T
Q
A
R
Y
V
S
C
Site 95
Y1176
G
R
G
T
Q
A
R
Y
V
S
C
R
D
A
L
Site 96
S1178
G
T
Q
A
R
Y
V
S
C
R
D
A
L
D
R
Site 97
S1190
L
D
R
I
A
D
E
S
Y
C
A
H
L
P
R
Site 98
Y1191
D
R
I
A
D
E
S
Y
C
A
H
L
P
R
P
Site 99
S1220
A
G
D
W
S
P
C
S
A
S
C
G
H
G
K
Site 100
Y1237
R
Q
V
L
C
M
N
Y
H
Q
P
I
D
E
N
Site 101
Y1245
H
Q
P
I
D
E
N
Y
C
D
P
E
V
R
P
Site 102
S1268
A
A
C
P
P
A
H
S
H
F
P
S
S
P
V
Site 103
S1272
P
A
H
S
H
F
P
S
S
P
V
Q
P
S
Y
Site 104
S1273
A
H
S
H
F
P
S
S
P
V
Q
P
S
Y
Y
Site 105
S1278
P
S
S
P
V
Q
P
S
Y
Y
L
S
T
N
L
Site 106
Y1279
S
S
P
V
Q
P
S
Y
Y
L
S
T
N
L
P
Site 107
Y1280
S
P
V
Q
P
S
Y
Y
L
S
T
N
L
P
L
Site 108
S1282
V
Q
P
S
Y
Y
L
S
T
N
L
P
L
T
Q
Site 109
T1288
L
S
T
N
L
P
L
T
Q
K
L
E
D
N
E
Site 110
S1315
W
R
T
G
P
W
G
S
C
S
S
S
C
S
G
Site 111
S1317
T
G
P
W
G
S
C
S
S
S
C
S
G
G
L
Site 112
S1318
G
P
W
G
S
C
S
S
S
C
S
G
G
L
Q
Site 113
S1319
P
W
G
S
C
S
S
S
C
S
G
G
L
Q
H
Site 114
S1321
G
S
C
S
S
S
C
S
G
G
L
Q
H
R
A
Site 115
S1340
D
E
N
G
Q
S
A
S
Y
C
D
A
A
S
K
Site 116
S1346
A
S
Y
C
D
A
A
S
K
P
P
E
L
Q
Q
Site 117
S1430
Q
E
P
W
T
S
C
S
A
S
C
G
K
G
R
Site 118
S1432
P
W
T
S
C
S
A
S
C
G
K
G
R
K
Y
Site 119
Y1439
S
C
G
K
G
R
K
Y
R
E
V
F
C
I
D
Site 120
T1455
F
Q
R
K
L
E
D
T
N
C
S
Q
V
Q
K
Site 121
S1458
K
L
E
D
T
N
C
S
Q
V
Q
K
P
P
T
Site 122
T1465
S
Q
V
Q
K
P
P
T
H
K
A
C
R
S
V
Site 123
Y1499
G
V
Q
Q
R
D
V
Y
C
R
L
K
G
V
G
Site 124
T1517
E
E
M
C
D
Q
S
T
R
P
C
S
Q
R
R
Site 125
S1521
D
Q
S
T
R
P
C
S
Q
R
R
C
W
S
Q
Site 126
T1545
R
G
R
L
N
C
S
T
S
C
E
R
K
D
S
Site 127
S1546
G
R
L
N
C
S
T
S
C
E
R
K
D
S
H
Site 128
S1552
T
S
C
E
R
K
D
S
H
Q
R
M
E
C
T
Site 129
Y1571
R
Q
V
N
E
I
V
Y
N
S
S
T
I
S
L
Site 130
S1574
N
E
I
V
Y
N
S
S
T
I
S
L
T
S
K
Site 131
S1577
V
Y
N
S
S
T
I
S
L
T
S
K
N
C
R
Site 132
S1580
S
S
T
I
S
L
T
S
K
N
C
R
N
P
P
Site 133
T1613
F
S
Y
R
Q
R
I
T
Y
C
T
E
I
P
S
Site 134
Y1614
S
Y
R
Q
R
I
T
Y
C
T
E
I
P
S
T
Site 135
T1616
R
Q
R
I
T
Y
C
T
E
I
P
S
T
K
K
Site 136
T1621
Y
C
T
E
I
P
S
T
K
K
H
K
L
H
R
Site 137
T1683
K
R
Q
V
K
C
I
T
K
H
G
L
S
S
D
Site 138
Y1705
P
G
A
Q
K
K
C
Y
A
N
D
C
K
S
F
Site 139
Y1730
H
I
R
K
D
G
D
Y
Y
L
N
I
K
G
R
Site 140
Y1731
I
R
K
D
G
D
Y
Y
L
N
I
K
G
R
I
Site 141
Y1747
K
I
Y
C
A
D
M
Y
L
E
N
P
K
E
Y
Site 142
T1756
E
N
P
K
E
Y
L
T
L
V
Q
G
E
E
N
Site 143
S1765
V
Q
G
E
E
N
F
S
E
V
Y
G
F
R
L
Site 144
Y1776
G
F
R
L
K
N
P
Y
Q
C
P
F
N
G
S
Site 145
Y1799
N
G
H
L
A
A
G
Y
T
V
F
S
K
I
R
Site 146
T1810
S
K
I
R
I
D
L
T
S
M
Q
I
K
T
T
Site 147
S1811
K
I
R
I
D
L
T
S
M
Q
I
K
T
T
D
Site 148
Y1839
F
A
T
A
G
D
C
Y
S
A
F
R
C
P
Q
Site 149
S1850
R
C
P
Q
G
Q
F
S
I
N
L
S
G
T
G
Site 150
S1854
G
Q
F
S
I
N
L
S
G
T
G
M
K
I
S
Site 151
S1861
S
G
T
G
M
K
I
S
S
T
A
K
W
L
T
Site 152
S1862
G
T
G
M
K
I
S
S
T
A
K
W
L
T
Q
Site 153
T1863
T
G
M
K
I
S
S
T
A
K
W
L
T
Q
G
Site 154
T1868
S
S
T
A
K
W
L
T
Q
G
S
Y
T
S
V
Site 155
S1871
A
K
W
L
T
Q
G
S
Y
T
S
V
S
I
R
Site 156
Y1872
K
W
L
T
Q
G
S
Y
T
S
V
S
I
R
R
Site 157
S1874
L
T
Q
G
S
Y
T
S
V
S
I
R
R
S
E
Site 158
S1876
Q
G
S
Y
T
S
V
S
I
R
R
S
E
D
G
Site 159
S1880
T
S
V
S
I
R
R
S
E
D
G
T
R
F
F
Site 160
T1884
I
R
R
S
E
D
G
T
R
F
F
G
K
C
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation