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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP12
Full Name:
NACHT, LRR and PYD domains-containing protein 12
Alias:
Clr19.3; Fcas2; Monarch1; Monarch-1; Monarch-1 splice form ii; Monarch-1 splice form iii; Monarch-1 splice form iv; Nal12; Nalp12; Nlr family, pyrin domain containing 12; Nlr family, pyrin domain containing 12 isoform 2; Nlrp12; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; Pan6; Pypaf7; Pyrin-containing apaf1-like protein 7; Rno; Rno2
Type:
Mass (Da):
120170
Number AA:
UniProt ID:
P59046
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008656
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006919
GO:0043124
GO:0045751
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
D
G
L
C
R
L
S
T
Y
L
E
E
L
E
Site 2
T15
D
G
L
C
R
L
S
T
Y
L
E
E
L
E
A
Site 3
Y31
E
L
K
K
F
K
L
Y
L
G
T
A
T
E
L
Site 4
S47
E
G
K
I
P
W
G
S
M
E
K
A
G
P
L
Site 5
S75
E
A
W
R
L
A
L
S
T
F
E
R
I
N
R
Site 6
T76
A
W
R
L
A
L
S
T
F
E
R
I
N
R
K
Site 7
T98
R
E
D
L
V
R
D
T
P
P
G
G
P
S
S
Site 8
S105
T
P
P
G
G
P
S
S
L
G
N
Q
S
T
C
Site 9
S110
P
S
S
L
G
N
Q
S
T
C
L
L
E
V
S
Site 10
T120
L
L
E
V
S
L
V
T
P
R
K
D
P
Q
E
Site 11
Y132
P
Q
E
T
Y
R
D
Y
V
R
R
K
F
R
L
Site 12
S154
L
G
E
C
V
N
L
S
H
R
Y
T
R
L
L
Site 13
T158
V
N
L
S
H
R
Y
T
R
L
L
L
V
K
E
Site 14
T179
V
Q
Q
Q
L
L
D
T
G
R
G
H
A
R
T
Site 15
T186
T
G
R
G
H
A
R
T
V
G
H
Q
A
S
P
Site 16
S192
R
T
V
G
H
Q
A
S
P
I
K
I
E
T
L
Site 17
T212
E
R
P
E
P
P
R
T
V
V
M
Q
G
A
A
Site 18
Y246
L
F
Q
G
R
F
D
Y
L
F
Y
I
N
C
R
Site 19
Y249
G
R
F
D
Y
L
F
Y
I
N
C
R
E
M
N
Site 20
S302
G
F
D
E
L
K
P
S
F
H
D
P
Q
G
P
Site 21
T320
C
W
E
E
K
R
P
T
E
L
L
L
N
S
L
Site 22
T345
L
L
I
T
T
R
P
T
A
L
E
K
L
H
R
Site 23
Y373
S
E
A
E
R
K
E
Y
F
Y
K
Y
F
H
N
Site 24
Y375
A
E
R
K
E
Y
F
Y
K
Y
F
H
N
A
E
Site 25
Y377
R
K
E
Y
F
Y
K
Y
F
H
N
A
E
Q
A
Site 26
Y390
Q
A
G
Q
V
F
N
Y
V
R
D
N
E
P
L
Site 27
T427
G
G
G
L
L
R
Q
T
S
R
T
T
T
A
V
Site 28
S428
G
G
L
L
R
Q
T
S
R
T
T
T
A
V
Y
Site 29
T431
L
R
Q
T
S
R
T
T
T
A
V
Y
M
L
Y
Site 30
T432
R
Q
T
S
R
T
T
T
A
V
Y
M
L
Y
L
Site 31
S463
P
N
Q
R
G
L
C
S
L
A
A
D
G
L
W
Site 32
Y509
K
D
I
N
C
E
R
Y
Y
S
F
I
H
L
S
Site 33
Y510
D
I
N
C
E
R
Y
Y
S
F
I
H
L
S
F
Site 34
T542
A
G
P
D
Q
D
V
T
R
L
L
T
E
Y
A
Site 35
T546
Q
D
V
T
R
L
L
T
E
Y
A
F
S
E
R
Site 36
Y548
V
T
R
L
L
T
E
Y
A
F
S
E
R
S
F
Site 37
S554
E
Y
A
F
S
E
R
S
F
L
A
L
T
S
R
Site 38
S573
L
L
N
E
E
T
R
S
H
L
E
K
S
L
C
Site 39
S578
T
R
S
H
L
E
K
S
L
C
W
K
V
S
P
Site 40
S597
D
L
L
Q
W
I
Q
S
K
A
Q
S
D
G
S
Site 41
S601
W
I
Q
S
K
A
Q
S
D
G
S
T
L
Q
Q
Site 42
S604
S
K
A
Q
S
D
G
S
T
L
Q
Q
G
S
L
Site 43
T605
K
A
Q
S
D
G
S
T
L
Q
Q
G
S
L
E
Site 44
Y618
L
E
F
F
S
C
L
Y
E
I
Q
E
E
E
F
Site 45
Y666
S
A
Q
V
L
H
L
Y
G
A
T
Y
S
A
D
Site 46
Y670
L
H
L
Y
G
A
T
Y
S
A
D
G
E
D
R
Site 47
S671
H
L
Y
G
A
T
Y
S
A
D
G
E
D
R
A
Site 48
S681
G
E
D
R
A
R
C
S
A
G
A
H
T
L
L
Site 49
S719
N
P
N
L
I
E
L
S
L
Y
R
N
A
L
G
Site 50
Y721
N
L
I
E
L
S
L
Y
R
N
A
L
G
S
R
Site 51
S755
R
L
K
R
C
R
I
S
S
S
A
C
E
D
L
Site 52
S756
L
K
R
C
R
I
S
S
S
A
C
E
D
L
S
Site 53
S757
K
R
C
R
I
S
S
S
A
C
E
D
L
S
A
Site 54
S778
N
L
T
R
M
D
L
S
G
N
G
V
G
F
P
Site 55
S881
D
E
L
A
S
T
L
S
V
N
Q
S
L
R
E
Site 56
S885
S
T
L
S
V
N
Q
S
L
R
E
L
D
L
S
Site 57
S892
S
L
R
E
L
D
L
S
L
N
E
L
G
D
L
Site 58
T912
C
E
G
L
R
H
P
T
C
K
L
Q
T
L
R
Site 59
T917
H
P
T
C
K
L
Q
T
L
R
L
G
I
C
R
Site 60
S949
N
L
R
E
L
D
L
S
F
N
D
L
G
D
W
Site 61
S979
L
Q
K
L
W
L
D
S
C
G
L
T
A
K
A
Site 62
T1001
L
G
I
N
Q
T
L
T
D
L
Y
L
T
N
N
Site 63
Y1004
N
Q
T
L
T
D
L
Y
L
T
N
N
A
L
G
Site 64
S1023
R
L
L
C
K
R
L
S
H
P
G
C
K
L
R
Site 65
S1045
D
L
N
K
M
T
H
S
R
L
A
A
L
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation