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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP11
Full Name:
NACHT, LRR and PYD domains-containing protein 11
Alias:
Nucleotide-binding oligomerization domain protein 17;PAAD-and NACHT domain-containing protein 10;PYRIN-containing APAF1-like protein 6
Type:
Mass (Da):
117779
Number AA:
1033
UniProt ID:
P59045
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
T
D
F
D
L
L
W
Y
L
E
N
L
S
D
K
Site 2
S19
L
W
Y
L
E
N
L
S
D
K
E
F
Q
S
F
Site 3
S25
L
S
D
K
E
F
Q
S
F
K
K
Y
L
A
R
Site 4
Y29
E
F
Q
S
F
K
K
Y
L
A
R
K
I
L
D
Site 5
Y64
P
I
S
Y
E
G
Q
Y
I
W
N
M
L
F
S
Site 6
Y136
F
Y
I
L
Q
L
A
Y
D
S
T
S
Y
Y
S
Site 7
S138
I
L
Q
L
A
Y
D
S
T
S
Y
Y
S
A
N
Site 8
T139
L
Q
L
A
Y
D
S
T
S
Y
Y
S
A
N
N
Site 9
S140
Q
L
A
Y
D
S
T
S
Y
Y
S
A
N
N
L
Site 10
Y142
A
Y
D
S
T
S
Y
Y
S
A
N
N
L
N
V
Site 11
S198
I
N
Q
M
T
N
S
S
L
A
E
L
I
A
K
Site 12
S247
V
N
E
S
A
L
C
S
N
S
T
Q
K
V
P
Site 13
S249
E
S
A
L
C
S
N
S
T
Q
K
V
P
I
P
Site 14
S276
P
G
C
W
F
L
I
S
S
R
P
T
R
G
N
Site 15
T280
F
L
I
S
S
R
P
T
R
G
N
N
V
K
T
Site 16
T287
T
R
G
N
N
V
K
T
F
L
K
E
V
D
C
Site 17
T296
L
K
E
V
D
C
C
T
T
L
Q
L
S
N
G
Site 18
T297
K
E
V
D
C
C
T
T
L
Q
L
S
N
G
K
Site 19
Y308
S
N
G
K
R
E
I
Y
F
N
S
F
F
K
D
Site 20
S311
K
R
E
I
Y
F
N
S
F
F
K
D
R
Q
R
Site 21
S320
F
K
D
R
Q
R
A
S
A
A
L
Q
L
V
H
Site 22
T385
L
T
S
E
A
G
L
T
A
N
Q
Y
H
L
G
Site 23
Y389
A
G
L
T
A
N
Q
Y
H
L
G
L
L
K
R
Site 24
S439
A
A
N
I
L
L
P
S
N
T
H
K
D
R
Y
Site 25
Y446
S
N
T
H
K
D
R
Y
K
F
I
H
L
N
V
Site 26
S473
V
P
N
Y
L
I
P
S
G
S
R
E
Y
K
E
Site 27
S475
N
Y
L
I
P
S
G
S
R
E
Y
K
E
K
R
Site 28
Y478
I
P
S
G
S
R
E
Y
K
E
K
R
E
Q
Y
Site 29
Y485
Y
K
E
K
R
E
Q
Y
S
D
F
N
Q
V
F
Site 30
S486
K
E
K
R
E
Q
Y
S
D
F
N
Q
V
F
T
Site 31
T509
N
R
R
K
I
L
E
T
S
F
G
Y
Q
L
P
Site 32
S510
R
R
K
I
L
E
T
S
F
G
Y
Q
L
P
M
Site 33
T540
D
R
D
P
E
K
L
T
H
H
M
P
L
F
Y
Site 34
Y550
M
P
L
F
Y
C
L
Y
E
N
R
E
E
E
F
Site 35
T560
R
E
E
E
F
V
K
T
I
V
D
A
L
M
E
Site 36
Y571
A
L
M
E
V
T
V
Y
L
Q
S
D
K
D
M
Site 37
T593
D
Y
C
C
H
L
R
T
L
K
L
S
V
Q
R
Site 38
S597
H
L
R
T
L
K
L
S
V
Q
R
I
F
Q
N
Site 39
T612
K
E
P
L
I
R
P
T
A
S
Q
M
K
S
L
Site 40
S614
P
L
I
R
P
T
A
S
Q
M
K
S
L
V
Y
Site 41
S618
P
T
A
S
Q
M
K
S
L
V
Y
W
R
E
I
Site 42
Y621
S
Q
M
K
S
L
V
Y
W
R
E
I
C
S
L
Site 43
Y630
R
E
I
C
S
L
F
Y
T
M
E
S
L
R
E
Site 44
S649
D
N
D
L
N
G
I
S
E
R
I
L
S
K
A
Site 45
S654
G
I
S
E
R
I
L
S
K
A
L
E
H
S
S
Site 46
S660
L
S
K
A
L
E
H
S
S
C
K
L
R
T
L
Site 47
S661
S
K
A
L
E
H
S
S
C
K
L
R
T
L
K
Site 48
T666
H
S
S
C
K
L
R
T
L
K
L
S
Y
V
S
Site 49
S670
K
L
R
T
L
K
L
S
Y
V
S
T
A
S
G
Site 50
S690
K
A
L
A
R
N
R
S
L
T
Y
L
S
I
N
Site 51
T692
L
A
R
N
R
S
L
T
Y
L
S
I
N
C
T
Site 52
S695
N
R
S
L
T
Y
L
S
I
N
C
T
S
I
S
Site 53
S733
M
K
C
D
L
R
A
S
E
C
E
E
I
A
S
Site 54
T752
G
G
S
L
R
K
L
T
L
S
S
N
P
L
R
Site 55
S754
S
L
R
K
L
T
L
S
S
N
P
L
R
S
D
Site 56
S760
L
S
S
N
P
L
R
S
D
G
M
N
I
L
C
Site 57
S840
Q
L
E
E
L
H
L
S
G
C
F
F
S
S
D
Site 58
S864
A
T
N
E
K
L
R
S
L
E
I
G
S
N
K
Site 59
T914
R
S
L
A
S
V
L
T
T
N
K
T
L
E
R
Site 60
T915
S
L
A
S
V
L
T
T
N
K
T
L
E
R
L
Site 61
T968
Q
T
Q
Q
L
L
M
T
V
K
E
R
K
P
S
Site 62
S975
T
V
K
E
R
K
P
S
L
I
F
L
S
E
T
Site 63
S980
K
P
S
L
I
F
L
S
E
T
W
S
L
K
E
Site 64
T982
S
L
I
F
L
S
E
T
W
S
L
K
E
G
R
Site 65
S984
I
F
L
S
E
T
W
S
L
K
E
G
R
E
I
Site 66
T994
E
G
R
E
I
G
V
T
P
A
S
Q
P
G
S
Site 67
S1001
T
P
A
S
Q
P
G
S
I
I
P
N
S
N
L
Site 68
Y1010
I
P
N
S
N
L
D
Y
M
F
F
K
F
P
R
Site 69
S1019
F
F
K
F
P
R
M
S
A
A
M
R
T
S
N
Site 70
S1025
M
S
A
A
M
R
T
S
N
T
A
S
R
Q
P
Site 71
T1027
A
A
M
R
T
S
N
T
A
S
R
Q
P
L
_
Site 72
S1029
M
R
T
S
N
T
A
S
R
Q
P
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation