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Updated November 2019
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Protein Info
Short Name:
EPPK1
Full Name:
Epiplakin
Alias:
450 kDa epidermal antigen; Epidermal autoantigen 450K; EPIPL; EPIPL1; Epiplakin 1
Type:
Cytoskeletal protein
Mass (Da):
553094
Number AA:
5065
UniProt ID:
P58107
International Prot ID:
IPI00010951
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
A
T
L
G
A
G
T
P
P
R
P
Q
A
R
Site 2
S17
P
P
R
P
Q
A
R
S
I
A
G
V
Y
V
E
Site 3
S31
E
A
S
G
Q
A
Q
S
V
Y
A
A
M
E
Q
Site 4
Y33
S
G
Q
A
Q
S
V
Y
A
A
M
E
Q
G
L
Site 5
S71
R
G
Q
L
L
P
V
S
K
A
L
Q
Q
G
L
Site 6
T94
L
L
A
A
E
R
A
T
T
G
Y
P
D
P
Y
Site 7
T95
L
A
A
E
R
A
T
T
G
Y
P
D
P
Y
G
Site 8
Y97
A
E
R
A
T
T
G
Y
P
D
P
Y
G
G
E
Site 9
Y101
T
T
G
Y
P
D
P
Y
G
G
E
K
L
A
L
Site 10
T159
Q
G
L
L
D
R
E
T
W
H
K
L
S
E
L
Site 11
S164
R
E
T
W
H
K
L
S
E
L
E
P
G
T
G
Site 12
T180
L
R
F
L
N
P
N
T
L
E
R
L
T
Y
H
Site 13
T185
P
N
T
L
E
R
L
T
Y
H
Q
L
L
E
R
Site 14
Y186
N
T
L
E
R
L
T
Y
H
Q
L
L
E
R
C
Site 15
S247
R
L
A
A
V
D
V
S
A
R
A
E
V
R
R
Site 16
Y255
A
R
A
E
V
R
R
Y
L
E
G
T
G
S
V
Site 17
S275
L
P
E
G
H
K
K
S
F
F
Q
A
A
T
E
Site 18
T308
H
T
L
V
D
P
I
T
G
Q
R
L
W
V
D
Site 19
T339
L
V
A
E
Q
A
V
T
G
H
H
D
P
F
S
Site 20
S346
T
G
H
H
D
P
F
S
G
S
Q
I
P
L
F
Site 21
S348
H
H
D
P
F
S
G
S
Q
I
P
L
F
Q
A
Site 22
T403
C
G
C
L
D
E
D
T
Q
R
Q
L
S
Q
A
Site 23
S408
E
D
T
Q
R
Q
L
S
Q
A
G
S
F
S
D
Site 24
S412
R
Q
L
S
Q
A
G
S
F
S
D
G
T
H
G
Site 25
S414
L
S
Q
A
G
S
F
S
D
G
T
H
G
G
L
Site 26
T417
A
G
S
F
S
D
G
T
H
G
G
L
R
Y
E
Site 27
Y460
Q
G
P
P
F
I
K
Y
S
T
R
Q
A
L
S
Site 28
S461
G
P
P
F
I
K
Y
S
T
R
Q
A
L
S
T
Site 29
S467
Y
S
T
R
Q
A
L
S
T
A
T
A
T
V
S
Site 30
S474
S
T
A
T
A
T
V
S
V
G
K
F
R
G
R
Site 31
S484
K
F
R
G
R
P
V
S
L
W
E
L
L
F
S
Site 32
S491
S
L
W
E
L
L
F
S
E
A
I
S
S
E
Q
Site 33
Y506
R
A
M
L
A
Q
Q
Y
Q
E
G
T
L
S
V
Site 34
S512
Q
Y
Q
E
G
T
L
S
V
E
K
L
A
A
E
Site 35
S521
E
K
L
A
A
E
L
S
A
T
L
E
Q
A
A
Site 36
T543
S
G
L
R
D
T
V
T
P
G
E
L
L
K
A
Site 37
Y558
E
I
I
D
Q
D
L
Y
E
R
L
E
H
G
Q
Site 38
S573
A
T
A
K
D
V
G
S
L
A
S
A
Q
R
Y
Site 39
S576
K
D
V
G
S
L
A
S
A
Q
R
Y
L
Q
G
Site 40
S600
P
G
S
Q
E
R
L
S
I
Y
E
A
R
C
K
Site 41
Y602
S
Q
E
R
L
S
I
Y
E
A
R
C
K
G
L
Site 42
S638
P
K
A
N
K
G
H
S
V
E
E
A
L
R
A
Site 43
T664
L
S
A
E
R
A
V
T
G
Y
T
D
P
Y
T
Site 44
Y666
A
E
R
A
V
T
G
Y
T
D
P
Y
T
G
Q
Site 45
Y670
V
T
G
Y
T
D
P
Y
T
G
Q
Q
I
S
L
Site 46
T671
T
G
Y
T
D
P
Y
T
G
Q
Q
I
S
L
F
Site 47
S676
P
Y
T
G
Q
Q
I
S
L
F
Q
A
M
Q
K
Site 48
Y719
R
V
P
V
D
V
A
Y
R
R
G
Y
F
D
Q
Site 49
Y723
D
V
A
Y
R
R
G
Y
F
D
Q
M
L
N
L
Site 50
S736
N
L
I
L
L
D
P
S
D
D
T
K
G
F
F
Site 51
T739
L
L
D
P
S
D
D
T
K
G
F
F
D
P
N
Site 52
T747
K
G
F
F
D
P
N
T
H
E
N
L
T
Y
L
Site 53
Y753
N
T
H
E
N
L
T
Y
L
Q
L
L
E
R
C
Site 54
T766
R
C
V
R
D
P
E
T
G
L
Y
L
L
P
L
Site 55
Y769
R
D
P
E
T
G
L
Y
L
L
P
L
S
S
T
Site 56
S778
L
P
L
S
S
T
Q
S
P
L
V
D
S
A
T
Site 57
T785
S
P
L
V
D
S
A
T
Q
Q
A
F
Q
N
L
Site 58
S795
A
F
Q
N
L
L
L
S
V
K
Y
G
R
F
Q
Site 59
Y798
N
L
L
L
S
V
K
Y
G
R
F
Q
G
Q
R
Site 60
S807
R
F
Q
G
Q
R
V
S
A
W
E
L
I
N
S
Site 61
S814
S
A
W
E
L
I
N
S
E
Y
F
S
E
G
R
Site 62
Y816
W
E
L
I
N
S
E
Y
F
S
E
G
R
R
R
Site 63
S818
L
I
N
S
E
Y
F
S
E
G
R
R
R
Q
L
Site 64
Y829
R
R
Q
L
L
R
R
Y
R
Q
R
E
V
T
L
Site 65
T835
R
Y
R
Q
R
E
V
T
L
G
Q
V
A
K
L
Site 66
T847
A
K
L
L
E
A
E
T
Q
R
Q
A
D
I
M
Site 67
T863
P
A
L
R
S
R
V
T
V
H
Q
L
L
E
A
Site 68
S915
G
G
V
R
L
L
P
S
G
Q
R
L
S
L
Y
Site 69
S920
L
P
S
G
Q
R
L
S
L
Y
Q
A
M
R
Q
Site 70
Y922
S
G
Q
R
L
S
L
Y
Q
A
M
R
Q
K
L
Site 71
S953
G
T
I
M
D
P
H
S
P
E
S
L
S
V
D
Site 72
S956
M
D
P
H
S
P
E
S
L
S
V
D
E
A
V
Site 73
S958
P
H
S
P
E
S
L
S
V
D
E
A
V
R
R
Site 74
Y973
G
V
V
G
P
E
L
Y
G
R
L
K
R
A
E
Site 75
S991
A
G
F
R
D
P
F
S
G
K
Q
V
S
V
F
Site 76
S996
P
F
S
G
K
Q
V
S
V
F
Q
A
M
K
K
Site 77
T1028
T
G
G
I
I
D
P
T
S
H
H
H
L
P
M
Site 78
Y1043
P
V
A
I
Q
R
G
Y
V
D
Q
E
M
E
T
Site 79
T1050
Y
V
D
Q
E
M
E
T
A
L
S
S
S
S
E
Site 80
S1053
Q
E
M
E
T
A
L
S
S
S
S
E
T
F
P
Site 81
S1056
E
T
A
L
S
S
S
S
E
T
F
P
T
P
D
Site 82
T1058
A
L
S
S
S
S
E
T
F
P
T
P
D
G
Q
Site 83
T1061
S
S
S
E
T
F
P
T
P
D
G
Q
G
R
T
Site 84
S1069
P
D
G
Q
G
R
T
S
Y
A
Q
L
L
E
E
Site 85
Y1070
D
G
Q
G
R
T
S
Y
A
Q
L
L
E
E
C
Site 86
T1082
E
E
C
P
R
D
E
T
S
G
L
H
L
L
P
Site 87
S1083
E
C
P
R
D
E
T
S
G
L
H
L
L
P
L
Site 88
S1093
H
L
L
P
L
P
E
S
A
P
A
L
P
T
E
Site 89
S1118
P
G
A
K
D
G
T
S
L
W
D
L
L
S
S
Site 90
S1124
T
S
L
W
D
L
L
S
S
C
H
F
T
E
E
Site 91
S1125
S
L
W
D
L
L
S
S
C
H
F
T
E
E
Q
Site 92
T1129
L
L
S
S
C
H
F
T
E
E
Q
R
R
G
L
Site 93
T1146
D
V
Q
E
G
R
T
T
V
P
Q
L
L
A
S
Site 94
S1203
A
L
A
Q
G
T
Q
S
P
A
Q
V
A
E
Q
Site 95
S1231
A
G
V
L
L
Q
P
S
G
A
K
A
S
I
A
Site 96
S1274
P
L
N
N
Q
R
L
S
V
E
D
A
V
K
V
Site 97
S1289
G
L
V
G
R
E
L
S
E
Q
L
G
Q
A
E
Site 98
Y1302
A
E
R
A
A
A
G
Y
P
D
P
Y
S
R
A
Site 99
Y1306
A
A
G
Y
P
D
P
Y
S
R
A
S
L
S
L
Site 100
S1307
A
G
Y
P
D
P
Y
S
R
A
S
L
S
L
W
Site 101
S1310
P
D
P
Y
S
R
A
S
L
S
L
W
Q
A
M
Site 102
S1312
P
Y
S
R
A
S
L
S
L
W
Q
A
M
E
K
Site 103
T1369
T
Q
T
S
Q
V
L
T
A
V
D
K
D
N
K
Site 104
T1388
P
S
A
R
D
Q
V
T
Y
Q
Q
L
R
E
R
Site 105
Y1389
S
A
R
D
Q
V
T
Y
Q
Q
L
R
E
R
C
Site 106
S1433
R
A
M
K
V
P
V
S
T
G
R
F
K
G
C
Site 107
T1434
A
M
K
V
P
V
S
T
G
R
F
K
G
C
S
Site 108
Y1452
W
D
L
L
L
S
E
Y
V
G
A
D
K
R
R
Site 109
T1481
R
Q
V
V
S
A
V
T
A
L
V
E
A
A
E
Site 110
T1495
E
R
Q
P
L
Q
A
T
F
R
G
L
R
K
Q
Site 111
S1504
R
G
L
R
K
Q
V
S
A
R
D
L
F
R
A
Site 112
S1515
L
F
R
A
Q
L
I
S
R
K
T
L
D
E
L
Site 113
T1518
A
Q
L
I
S
R
K
T
L
D
E
L
S
Q
G
Site 114
S1523
R
K
T
L
D
E
L
S
Q
G
T
T
T
V
K
Site 115
T1527
D
E
L
S
Q
G
T
T
T
V
K
E
V
A
E
Site 116
S1537
K
E
V
A
E
M
D
S
V
K
R
S
L
E
G
Site 117
S1541
E
M
D
S
V
K
R
S
L
E
G
G
N
F
I
Site 118
S1561
Q
G
T
Q
E
R
M
S
I
P
E
A
L
R
R
Site 119
T1599
P
A
E
N
R
K
L
T
V
E
E
A
F
K
A
Site 120
Y1614
G
M
F
G
K
E
T
Y
V
K
L
L
S
A
E
Site 121
Y1680
R
V
P
V
D
V
A
Y
R
C
G
Y
F
D
E
Site 122
Y1684
D
V
A
Y
R
C
G
Y
F
D
E
E
M
N
R
Site 123
S1697
N
R
I
L
A
D
P
S
D
D
T
K
G
F
F
Site 124
T1700
L
A
D
P
S
D
D
T
K
G
F
F
D
P
N
Site 125
T1727
R
C
V
E
D
P
E
T
G
L
Y
L
L
Q
I
Site 126
Y1730
E
D
P
E
T
G
L
Y
L
L
Q
I
I
K
K
Site 127
Y1741
I
I
K
K
G
E
N
Y
V
Y
I
N
E
A
T
Site 128
Y1743
K
K
G
E
N
Y
V
Y
I
N
E
A
T
R
H
Site 129
S1754
A
T
R
H
V
L
Q
S
R
T
A
K
M
R
V
Site 130
S1776
V
S
F
W
D
L
L
S
S
P
Y
F
T
E
D
Site 131
S1777
S
F
W
D
L
L
S
S
P
Y
F
T
E
D
R
Site 132
T1781
L
L
S
S
P
Y
F
T
E
D
R
K
R
E
L
Site 133
Y1792
K
R
E
L
I
Q
E
Y
G
A
Q
S
G
G
L
Site 134
T1808
K
L
L
E
I
I
T
T
T
I
E
E
T
E
T
Site 135
T1813
I
T
T
T
I
E
E
T
E
T
Q
N
Q
G
I
Site 136
T1815
T
T
I
E
E
T
E
T
Q
N
Q
G
I
K
V
Site 137
T1830
A
A
I
R
G
E
V
T
A
A
D
L
F
N
S
Site 138
T1844
S
R
V
I
D
Q
K
T
L
H
T
L
R
V
G
Site 139
T1847
I
D
Q
K
T
L
H
T
L
R
V
G
R
T
G
Site 140
S1859
R
T
G
G
Q
A
L
S
T
L
E
C
V
K
P
Site 141
T1860
T
G
G
Q
A
L
S
T
L
E
C
V
K
P
Y
Site 142
S1887
P
S
T
R
E
V
M
S
L
H
E
A
S
R
K
Site 143
T1920
G
F
L
L
D
P
C
T
R
Q
K
L
S
V
D
Site 144
S1925
P
C
T
R
Q
K
L
S
V
D
E
A
V
D
V
Site 145
T1951
L
K
A
E
R
A
A
T
G
Y
R
D
P
A
T
Site 146
Y1953
A
E
R
A
A
T
G
Y
R
D
P
A
T
G
D
Site 147
T1958
T
G
Y
R
D
P
A
T
G
D
T
I
P
L
F
Site 148
T1961
R
D
P
A
T
G
D
T
I
P
L
F
Q
A
M
Site 149
T2004
H
H
R
L
P
L
E
T
A
Y
R
R
G
C
L
Site 150
Y2006
R
L
P
L
E
T
A
Y
R
R
G
C
L
H
K
Site 151
Y2016
G
C
L
H
K
D
I
Y
A
L
I
S
D
Q
K
Site 152
T2034
K
R
F
V
D
P
N
T
Q
E
K
V
S
Y
R
Site 153
S2039
P
N
T
Q
E
K
V
S
Y
R
E
L
Q
E
R
Site 154
Y2040
N
T
Q
E
K
V
S
Y
R
E
L
Q
E
R
C
Site 155
T2053
R
C
R
P
Q
E
D
T
G
W
V
L
F
P
V
Site 156
S2067
V
N
K
A
A
R
D
S
E
H
I
D
D
E
T
Site 157
T2074
S
E
H
I
D
D
E
T
R
R
A
L
E
A
E
Site 158
T2086
E
A
E
Q
V
E
I
T
V
G
R
F
R
G
Q
Site 159
T2096
R
F
R
G
Q
K
P
T
L
W
A
L
L
N
S
Site 160
Y2105
W
A
L
L
N
S
E
Y
V
T
E
E
K
K
L
Site 161
T2107
L
L
N
S
E
Y
V
T
E
E
K
K
L
Q
L
Site 162
Y2118
K
L
Q
L
V
R
M
Y
R
T
H
T
R
R
A
Site 163
T2122
V
R
M
Y
R
T
H
T
R
R
A
L
Q
T
V
Site 164
T2128
H
T
R
R
A
L
Q
T
V
A
Q
L
I
L
E
Site 165
T2142
E
L
I
E
K
Q
E
T
S
N
K
H
L
W
F
Site 166
T2157
Q
G
I
R
R
Q
I
T
A
S
E
L
L
S
S
Site 167
T2177
E
M
L
Q
D
L
E
T
G
R
S
T
T
Q
E
Site 168
S2180
Q
D
L
E
T
G
R
S
T
T
Q
E
L
M
E
Site 169
T2181
D
L
E
T
G
R
S
T
T
Q
E
L
M
E
D
Site 170
T2182
L
E
T
G
R
S
T
T
Q
E
L
M
E
D
D
Site 171
Y2194
E
D
D
R
V
K
R
Y
L
E
G
T
S
C
I
Site 172
Y2221
R
Q
E
K
M
S
I
Y
Q
A
M
W
K
G
V
Site 173
S2257
P
V
R
N
L
R
L
S
V
E
E
P
V
P
A
Site 174
S2277
E
I
Q
E
K
L
L
S
A
E
R
A
V
T
G
Site 175
Y2338
R
V
P
V
D
V
A
Y
R
R
G
Y
F
D
E
Site 176
Y2342
D
V
A
Y
R
R
G
Y
F
D
E
E
M
N
R
Site 177
S2355
N
R
V
L
A
D
P
S
D
D
T
K
G
F
F
Site 178
T2366
K
G
F
F
D
P
N
T
H
E
N
L
T
Y
V
Site 179
T2371
P
N
T
H
E
N
L
T
Y
V
Q
L
L
R
R
Site 180
Y2372
N
T
H
E
N
L
T
Y
V
Q
L
L
R
R
C
Site 181
T2385
R
C
V
P
D
P
D
T
G
L
Y
M
L
Q
L
Site 182
Y2388
P
D
P
D
T
G
L
Y
M
L
Q
L
A
G
R
Site 183
S2397
L
Q
L
A
G
R
G
S
A
V
H
Q
L
S
E
Site 184
T2416
A
L
R
D
A
R
V
T
P
G
S
G
A
L
Q
Site 185
S2419
D
A
R
V
T
P
G
S
G
A
L
Q
G
Q
S
Site 186
Y2435
S
V
W
E
L
L
F
Y
R
E
V
S
E
D
R
Site 187
S2439
L
L
F
Y
R
E
V
S
E
D
R
R
Q
D
L
Site 188
S2448
D
R
R
Q
D
L
L
S
R
Y
R
A
G
T
L
Site 189
Y2450
R
Q
D
L
L
S
R
Y
R
A
G
T
L
T
V
Site 190
T2454
L
S
R
Y
R
A
G
T
L
T
V
E
E
L
G
Site 191
T2456
R
Y
R
A
G
T
L
T
V
E
E
L
G
A
T
Site 192
S2483
R
A
E
A
E
A
G
S
P
R
P
D
P
R
E
Site 193
T2496
R
E
A
L
R
A
A
T
M
E
V
K
V
G
R
Site 194
Y2519
W
D
V
L
A
S
G
Y
V
S
R
A
A
R
E
Site 195
S2521
V
L
A
S
G
Y
V
S
R
A
A
R
E
E
L
Site 196
T2547
P
A
L
T
R
R
L
T
A
I
I
E
E
A
E
Site 197
S2583
A
G
R
G
D
G
D
S
G
R
S
Q
R
E
G
Site 198
S2586
G
D
G
D
S
G
R
S
Q
R
E
G
Q
G
E
Site 199
T2612
A
A
R
R
Q
E
Q
T
L
R
D
A
T
M
E
Site 200
T2617
E
Q
T
L
R
D
A
T
M
E
V
Q
R
G
Q
Site 201
S2638
S
V
W
D
V
L
F
S
S
Y
L
S
E
A
R
Site 202
S2642
V
L
F
S
S
Y
L
S
E
A
R
R
D
E
L
Site 203
T2674
L
T
R
V
I
E
E
T
E
E
R
L
S
K
V
Site 204
S2679
E
E
T
E
E
R
L
S
K
V
S
F
R
G
L
Site 205
S2682
E
E
R
L
S
K
V
S
F
R
G
L
R
R
Q
Site 206
S2691
R
G
L
R
R
Q
V
S
A
S
E
L
H
T
S
Site 207
S2693
L
R
R
Q
V
S
A
S
E
L
H
T
S
G
I
Site 208
S2698
S
A
S
E
L
H
T
S
G
I
L
G
P
E
T
Site 209
T2705
S
G
I
L
G
P
E
T
L
R
D
L
A
Q
G
Site 210
T2715
D
L
A
Q
G
T
K
T
L
Q
E
V
T
E
M
Site 211
S2724
Q
E
V
T
E
M
D
S
V
K
R
Y
L
E
G
Site 212
Y2728
E
M
D
S
V
K
R
Y
L
E
G
T
S
C
I
Site 213
Y3053
W
D
V
L
A
S
G
Y
V
S
G
A
A
R
E
Site 214
S4050
D
R
R
Q
D
L
L
S
R
Y
R
A
S
T
L
Site 215
Y4052
R
Q
D
L
L
S
R
Y
R
A
S
T
L
T
V
Site 216
S4055
L
L
S
R
Y
R
A
S
T
L
T
V
E
E
L
Site 217
T4056
L
S
R
Y
R
A
S
T
L
T
V
E
E
L
G
Site 218
T4058
R
Y
R
A
S
T
L
T
V
E
E
L
G
A
T
Site 219
Y5042
N
T
H
E
N
L
T
Y
L
Q
L
L
Q
R
A
Site 220
T5050
L
Q
L
L
Q
R
A
T
L
D
P
E
T
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation