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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FOXL2
Full Name:
Forkhead box protein L2
Alias:
Blepharophimosis, epicanthus inversus, and ptosis 1; BPES; BPES1; Forkhead box L2; PFRK; PINTO; POF3
Type:
Transcription factor
Mass (Da):
38772
Number AA:
376
UniProt ID:
P58012
International Prot ID:
IPI00010550
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043028
GO:0005515
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006309
GO:0002074
GO:0042703
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
M
A
S
Y
P
E
P
E
D
A
Site 2
Y5
_
_
_
M
M
A
S
Y
P
E
P
E
D
A
A
Site 3
T20
G
A
L
L
A
P
E
T
G
R
T
V
K
E
P
Site 4
T23
L
A
P
E
T
G
R
T
V
K
E
P
E
G
P
Site 5
S33
E
P
E
G
P
P
P
S
P
G
K
G
G
G
G
Site 6
Y57
D
P
A
Q
K
P
P
Y
S
Y
V
A
L
I
A
Site 7
T76
E
S
A
E
K
R
L
T
L
S
G
I
Y
Q
Y
Site 8
Y81
R
L
T
L
S
G
I
Y
Q
Y
I
I
A
K
F
Site 9
Y83
T
L
S
G
I
Y
Q
Y
I
I
A
K
F
P
F
Site 10
Y91
I
I
A
K
F
P
F
Y
E
K
N
K
K
G
W
Site 11
S101
N
K
K
G
W
Q
N
S
I
R
H
N
L
S
L
Site 12
S107
N
S
I
R
H
N
L
S
L
N
E
C
F
I
K
Site 13
Y127
G
G
E
R
K
G
N
Y
W
T
L
D
P
A
C
Site 14
T129
E
R
K
G
N
Y
W
T
L
D
P
A
C
E
D
Site 15
Y143
D
M
F
E
K
G
N
Y
R
R
R
R
R
M
K
Site 16
Y186
A
G
A
G
A
D
G
Y
G
Y
L
A
P
P
K
Site 17
Y188
A
G
A
D
G
Y
G
Y
L
A
P
P
K
Y
L
Site 18
Y194
G
Y
L
A
P
P
K
Y
L
Q
S
G
F
L
N
Site 19
S197
A
P
P
K
Y
L
Q
S
G
F
L
N
N
S
W
Site 20
S203
Q
S
G
F
L
N
N
S
W
P
L
P
Q
P
P
Site 21
S211
W
P
L
P
Q
P
P
S
P
M
P
Y
A
S
C
Site 22
Y215
Q
P
P
S
P
M
P
Y
A
S
C
Q
M
A
A
Site 23
S238
A
A
A
A
G
P
G
S
P
G
A
A
A
V
V
Site 24
S254
G
L
A
G
P
A
A
S
Y
G
P
Y
T
R
V
Site 25
Y258
P
A
A
S
Y
G
P
Y
T
R
V
Q
S
M
A
Site 26
T259
A
A
S
Y
G
P
Y
T
R
V
Q
S
M
A
L
Site 27
S263
G
P
Y
T
R
V
Q
S
M
A
L
P
P
G
V
Site 28
S273
L
P
P
G
V
V
N
S
Y
N
G
L
G
G
P
Site 29
Y274
P
P
G
V
V
N
S
Y
N
G
L
G
G
P
P
Site 30
S323
A
P
P
P
G
Q
L
S
P
A
S
P
A
T
A
Site 31
S326
P
G
Q
L
S
P
A
S
P
A
T
A
A
P
P
Site 32
T329
L
S
P
A
S
P
A
T
A
A
P
P
A
P
A
Site 33
T338
A
P
P
A
P
A
P
T
S
A
P
G
L
Q
F
Site 34
S339
P
P
A
P
A
P
T
S
A
P
G
L
Q
F
A
Site 35
T367
Y
W
D
H
D
S
K
T
G
A
L
H
S
R
L
Site 36
S372
S
K
T
G
A
L
H
S
R
L
D
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation