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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SESN2
Full Name:
Sestrin-2
Alias:
DKFZp761M0212; Hi95; Hypoxia induced gene 95; SES2; SEST2; Sestrin 2
Type:
Enzyme, misc.
Mass (Da):
54494
Number AA:
480
UniProt ID:
P58004
International Prot ID:
IPI00010539
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
C
R
A
E
L
K
D
Y
L
R
F
A
P
G
G
Site 2
S26
A
P
G
G
V
G
D
S
G
P
G
E
E
Q
R
Site 3
S35
P
G
E
E
Q
R
E
S
R
A
R
R
G
P
R
Site 4
S45
R
R
G
P
R
G
P
S
A
F
I
P
V
E
E
Site 5
S60
V
L
R
E
G
A
E
S
L
E
Q
H
L
G
L
Site 6
Y98
T
S
F
W
R
L
H
Y
L
L
L
H
T
D
G
Site 7
S110
T
D
G
P
L
A
S
S
W
R
H
Y
I
A
I
Site 8
Y127
A
A
R
H
Q
C
S
Y
L
V
G
S
H
M
A
Site 9
T139
H
M
A
E
F
L
Q
T
G
G
D
P
E
W
L
Site 10
S160
P
E
K
L
R
K
L
S
E
I
N
K
L
L
A
Site 11
T174
A
H
R
P
W
L
I
T
K
E
H
I
Q
A
L
Site 12
T184
H
I
Q
A
L
L
K
T
G
E
H
T
W
S
L
Site 13
S190
K
T
G
E
H
T
W
S
L
A
E
L
I
Q
A
Site 14
S225
P
E
G
D
A
D
G
S
P
A
P
Q
A
P
T
Site 15
T232
S
P
A
P
Q
A
P
T
P
P
S
E
Q
S
S
Site 16
S235
P
Q
A
P
T
P
P
S
E
Q
S
S
P
P
S
Site 17
S238
P
T
P
P
S
E
Q
S
S
P
P
S
R
D
P
Site 18
S239
T
P
P
S
E
Q
S
S
P
P
S
R
D
P
L
Site 19
S242
S
E
Q
S
S
P
P
S
R
D
P
L
N
N
S
Site 20
S249
S
R
D
P
L
N
N
S
G
G
F
E
S
A
R
Site 21
S254
N
N
S
G
G
F
E
S
A
R
D
V
E
A
L
Site 22
T278
S
L
L
R
D
E
G
T
S
Q
E
E
M
E
S
Site 23
S279
L
L
R
D
E
G
T
S
Q
E
E
M
E
S
R
Site 24
S285
T
S
Q
E
E
M
E
S
R
F
E
L
E
K
S
Site 25
S292
S
R
F
E
L
E
K
S
E
S
L
L
V
T
P
Site 26
S294
F
E
L
E
K
S
E
S
L
L
V
T
P
S
A
Site 27
T298
K
S
E
S
L
L
V
T
P
S
A
D
I
L
E
Site 28
S307
S
A
D
I
L
E
P
S
P
H
P
D
M
L
C
Site 29
Y323
V
E
D
P
T
F
G
Y
E
D
F
T
R
R
G
Site 30
T327
T
F
G
Y
E
D
F
T
R
R
G
A
Q
A
P
Site 31
T336
R
G
A
Q
A
P
P
T
F
R
A
Q
D
Y
T
Site 32
Y342
P
T
F
R
A
Q
D
Y
T
W
E
D
H
G
Y
Site 33
Y349
Y
T
W
E
D
H
G
Y
S
L
I
Q
R
L
Y
Site 34
Y356
Y
S
L
I
Q
R
L
Y
P
E
G
G
Q
L
L
Site 35
S372
E
K
F
Q
A
A
Y
S
L
T
Y
N
T
I
A
Site 36
S387
M
H
S
G
V
D
T
S
V
L
R
R
A
I
W
Site 37
Y405
H
C
V
F
G
I
R
Y
D
D
Y
D
Y
G
E
Site 38
Y408
F
G
I
R
Y
D
D
Y
D
Y
G
E
V
N
Q
Site 39
Y410
I
R
Y
D
D
Y
D
Y
G
E
V
N
Q
L
L
Site 40
T427
N
L
K
V
Y
I
K
T
V
A
C
Y
P
E
K
Site 41
Y431
Y
I
K
T
V
A
C
Y
P
E
K
T
T
R
R
Site 42
T435
V
A
C
Y
P
E
K
T
T
R
R
M
Y
N
L
Site 43
Y470
R
M
Q
A
A
L
L
Y
A
L
R
A
I
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation