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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EVC
Full Name:
Ellis-van Creveld syndrome protein
Alias:
DWF-1
Type:
Mass (Da):
111990
Number AA:
992
UniProt ID:
P57679
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
G
G
A
A
C
K
S
D
A
R
L
L
L
G
Site 2
T55
C
R
A
G
R
Q
R
T
R
H
Q
K
D
D
T
Site 3
T62
T
R
H
Q
K
D
D
T
Q
N
L
L
K
N
L
Site 4
S71
N
L
L
K
N
L
E
S
N
A
Q
T
P
S
E
Site 5
T75
N
L
E
S
N
A
Q
T
P
S
E
T
G
S
P
Site 6
S77
E
S
N
A
Q
T
P
S
E
T
G
S
P
S
R
Site 7
T79
N
A
Q
T
P
S
E
T
G
S
P
S
R
R
R
Site 8
S81
Q
T
P
S
E
T
G
S
P
S
R
R
R
K
R
Site 9
S83
P
S
E
T
G
S
P
S
R
R
R
K
R
E
V
Site 10
S93
R
K
R
E
V
Q
M
S
K
D
K
E
A
V
D
Site 11
S106
V
D
E
C
E
P
P
S
N
S
N
I
T
A
F
Site 12
Y121
A
L
K
A
K
V
I
Y
P
I
N
Q
K
F
R
Site 13
S134
F
R
P
L
A
D
G
S
S
N
P
S
L
H
E
Site 14
S135
R
P
L
A
D
G
S
S
N
P
S
L
H
E
N
Site 15
S138
A
D
G
S
S
N
P
S
L
H
E
N
L
K
Q
Site 16
S156
P
H
Q
P
V
E
A
S
P
S
S
S
L
G
S
Site 17
S158
Q
P
V
E
A
S
P
S
S
S
L
G
S
L
S
Site 18
S159
P
V
E
A
S
P
S
S
S
L
G
S
L
S
Q
Site 19
S160
V
E
A
S
P
S
S
S
L
G
S
L
S
Q
G
Site 20
S163
S
P
S
S
S
L
G
S
L
S
Q
G
E
K
D
Site 21
S165
S
S
S
L
G
S
L
S
Q
G
E
K
D
D
C
Site 22
S173
Q
G
E
K
D
D
C
S
S
S
S
S
V
H
S
Site 23
S174
G
E
K
D
D
C
S
S
S
S
S
V
H
S
A
Site 24
S175
E
K
D
D
C
S
S
S
S
S
V
H
S
A
T
Site 25
S176
K
D
D
C
S
S
S
S
S
V
H
S
A
T
S
Site 26
S177
D
D
C
S
S
S
S
S
V
H
S
A
T
S
D
Site 27
S180
S
S
S
S
S
V
H
S
A
T
S
D
D
R
F
Site 28
T182
S
S
S
V
H
S
A
T
S
D
D
R
F
L
S
Site 29
S183
S
S
V
H
S
A
T
S
D
D
R
F
L
S
R
Site 30
S189
T
S
D
D
R
F
L
S
R
T
F
L
R
V
N
Site 31
T191
D
D
R
F
L
S
R
T
F
L
R
V
N
A
F
Site 32
T226
K
D
L
L
H
L
D
T
A
L
R
Q
E
K
H
Site 33
S253
D
L
L
P
K
K
K
S
D
D
E
L
Y
Q
K
Site 34
Y258
K
K
S
D
D
E
L
Y
Q
K
I
L
S
K
Q
Site 35
S281
K
G
L
Q
V
K
L
S
N
T
E
M
S
G
A
Site 36
S286
K
L
S
N
T
E
M
S
G
A
G
D
S
E
Y
Site 37
Y293
S
G
A
G
D
S
E
Y
I
T
L
A
D
V
E
Site 38
T295
A
G
D
S
E
Y
I
T
L
A
D
V
E
K
K
Site 39
Y306
V
E
K
K
E
R
E
Y
S
E
Q
L
I
D
N
Site 40
S307
E
K
K
E
R
E
Y
S
E
Q
L
I
D
N
M
Site 41
S335
L
V
D
Q
F
K
C
S
S
S
K
A
R
Q
L
Site 42
S337
D
Q
F
K
C
S
S
S
K
A
R
Q
L
M
M
Site 43
T345
K
A
R
Q
L
M
M
T
L
T
E
R
M
I
A
Site 44
T347
R
Q
L
M
M
T
L
T
E
R
M
I
A
A
E
Site 45
S360
A
E
G
L
L
C
D
S
Q
E
L
Q
A
L
D
Site 46
S414
L
A
G
E
G
K
L
S
G
R
Q
K
E
E
L
Site 47
T423
R
Q
K
E
E
L
L
T
Q
Q
H
K
A
F
W
Site 48
S437
W
Q
E
A
E
R
F
S
R
E
F
V
Q
R
G
Site 49
T449
Q
R
G
K
D
L
V
T
A
S
L
A
H
Q
V
Site 50
S451
G
K
D
L
V
T
A
S
L
A
H
Q
V
E
G
Site 51
S472
A
Q
E
E
E
Q
R
S
F
L
A
E
A
Q
P
Site 52
T480
F
L
A
E
A
Q
P
T
A
D
P
E
K
F
L
Site 53
Y556
L
P
P
E
E
C
D
Y
L
R
Q
E
V
Q
E
Site 54
S572
A
A
W
Q
L
G
K
S
N
R
F
R
R
Q
Q
Site 55
T606
A
L
S
S
V
L
Q
T
H
L
R
E
D
H
E
Site 56
T615
L
R
E
D
H
E
G
T
I
R
G
V
L
G
R
Site 57
T627
L
G
R
L
G
G
L
T
E
E
S
T
R
C
V
Site 58
S630
L
G
G
L
T
E
E
S
T
R
C
V
L
Q
G
Site 59
T631
G
G
L
T
E
E
S
T
R
C
V
L
Q
G
H
Site 60
T660
G
N
A
L
A
T
L
T
Q
M
R
L
S
G
K
Site 61
S665
T
L
T
Q
M
R
L
S
G
K
K
H
L
L
Q
Site 62
S685
R
A
L
E
Q
G
S
S
Q
C
L
D
E
H
Q
Site 63
T717
L
E
E
E
A
Q
Q
T
R
L
Q
L
Q
Q
R
Site 64
S759
A
R
N
A
A
T
K
S
R
A
K
D
R
D
D
Site 65
Y793
V
S
R
L
V
Q
A
Y
Y
Q
Q
I
G
R
I
Site 66
Y794
S
R
L
V
Q
A
Y
Y
Q
Q
I
G
R
I
M
Site 67
T814
R
K
L
Q
H
L
K
T
L
Q
G
E
R
M
E
Site 68
Y823
Q
G
E
R
M
E
N
Y
K
L
R
K
K
Q
E
Site 69
S832
L
R
K
K
Q
E
L
S
N
P
S
S
G
S
R
Site 70
S836
Q
E
L
S
N
P
S
S
G
S
R
T
A
G
G
Site 71
T840
N
P
S
S
G
S
R
T
A
G
G
A
H
E
T
Site 72
S848
A
G
G
A
H
E
T
S
Q
A
V
H
Q
R
M
Site 73
S857
A
V
H
Q
R
M
L
S
Q
Q
K
R
F
L
A
Site 74
T933
L
L
E
K
P
L
R
T
K
R
K
K
P
L
P
Site 75
S956
P
N
N
E
D
L
A
S
G
D
Q
T
S
G
S
Site 76
T960
D
L
A
S
G
D
Q
T
S
G
S
L
S
S
K
Site 77
S961
L
A
S
G
D
Q
T
S
G
S
L
S
S
K
R
Site 78
S963
S
G
D
Q
T
S
G
S
L
S
S
K
R
L
S
Site 79
S965
D
Q
T
S
G
S
L
S
S
K
R
L
S
Q
Q
Site 80
S966
Q
T
S
G
S
L
S
S
K
R
L
S
Q
Q
E
Site 81
S970
S
L
S
S
K
R
L
S
Q
Q
E
S
E
A
G
Site 82
S974
K
R
L
S
Q
Q
E
S
E
A
G
D
S
G
N
Site 83
S979
Q
E
S
E
A
G
D
S
G
N
S
K
K
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation