KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Slc8a3
Full Name:
Sodium/calcium exchanger 3
Alias:
Ncx3; Solute carrier family 8 (sodium/calcium exchanger), member 3
Type:
Membrane, Integral membrane protein
Mass (Da):
103010
Number AA:
927
UniProt ID:
P57103
International Prot ID:
IPI00337400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005432
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0007154
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
L
R
A
E
A
G
G
S
G
D
V
P
S
T
G
Site 2
S40
G
G
S
G
D
V
P
S
T
G
Q
N
N
E
S
Site 3
T41
G
S
G
D
V
P
S
T
G
Q
N
N
E
S
C
Site 4
S47
S
T
G
Q
N
N
E
S
C
S
G
S
S
D
C
Site 5
S49
G
Q
N
N
E
S
C
S
G
S
S
D
C
K
E
Site 6
S51
N
N
E
S
C
S
G
S
S
D
C
K
E
G
V
Site 7
S52
N
E
S
C
S
G
S
S
D
C
K
E
G
V
I
Site 8
T113
T
S
Q
E
R
E
V
T
I
K
K
P
N
G
E
Site 9
T121
I
K
K
P
N
G
E
T
S
T
T
T
I
R
V
Site 10
T124
P
N
G
E
T
S
T
T
T
I
R
V
W
N
E
Site 11
T125
N
G
E
T
S
T
T
T
I
R
V
W
N
E
T
Site 12
Y260
K
R
L
L
F
Y
K
Y
M
H
K
K
Y
R
T
Site 13
Y265
Y
K
Y
M
H
K
K
Y
R
T
D
K
H
R
G
Site 14
S312
E
G
K
E
V
D
E
S
R
R
E
M
I
R
I
Site 15
Y341
Q
L
V
E
M
A
N
Y
Y
A
L
S
H
Q
Q
Site 16
S350
A
L
S
H
Q
Q
K
S
R
A
F
Y
R
I
Q
Site 17
Y354
Q
Q
K
S
R
A
F
Y
R
I
Q
A
T
R
M
Site 18
S382
E
Q
A
K
K
A
S
S
M
S
E
V
H
T
D
Site 19
S384
A
K
K
A
S
S
M
S
E
V
H
T
D
E
P
Site 20
T388
S
S
M
S
E
V
H
T
D
E
P
E
D
F
I
Site 21
T428
K
G
G
D
M
S
K
T
M
Y
V
D
Y
K
T
Site 22
Y430
G
D
M
S
K
T
M
Y
V
D
Y
K
T
E
D
Site 23
Y433
S
K
T
M
Y
V
D
Y
K
T
E
D
G
S
A
Site 24
T435
T
M
Y
V
D
Y
K
T
E
D
G
S
A
N
A
Site 25
Y446
S
A
N
A
G
A
D
Y
E
F
T
E
G
T
V
Site 26
T452
D
Y
E
F
T
E
G
T
V
V
L
K
P
G
E
Site 27
S485
E
H
F
F
V
R
L
S
N
V
R
I
E
E
E
Site 28
T533
D
D
H
A
G
I
F
T
F
E
C
D
T
I
H
Site 29
S542
E
C
D
T
I
H
V
S
E
S
I
G
V
M
E
Site 30
T561
R
T
S
G
A
R
G
T
V
I
V
P
F
R
T
Site 31
T572
P
F
R
T
V
E
G
T
A
K
G
G
G
E
D
Site 32
T583
G
G
E
D
F
E
D
T
Y
G
E
L
E
F
K
Site 33
Y584
G
E
D
F
E
D
T
Y
G
E
L
E
F
K
N
Site 34
T594
L
E
F
K
N
D
E
T
V
K
T
I
R
V
K
Site 35
T597
K
N
D
E
T
V
K
T
I
R
V
K
I
V
D
Site 36
Y608
K
I
V
D
E
E
E
Y
E
R
Q
E
N
F
F
Site 37
S629
K
W
M
E
R
G
I
S
A
L
L
L
S
P
D
Site 38
S634
G
I
S
A
L
L
L
S
P
D
V
T
D
R
K
Site 39
T638
L
L
L
S
P
D
V
T
D
R
K
L
T
M
E
Site 40
T643
D
V
T
D
R
K
L
T
M
E
E
E
E
A
K
Site 41
Y674
E
V
I
I
E
E
S
Y
E
F
K
T
T
V
D
Site 42
T679
E
S
Y
E
F
K
T
T
V
D
K
L
I
K
K
Site 43
T707
D
Q
F
M
E
A
I
T
V
S
A
A
G
D
E
Site 44
S719
G
D
E
D
E
D
E
S
G
E
E
R
L
P
S
Site 45
S726
S
G
E
E
R
L
P
S
C
F
D
Y
V
M
H
Site 46
S820
Q
D
V
Y
A
D
A
S
I
G
N
V
T
G
S
Site 47
S857
Q
G
Q
E
F
H
V
S
A
G
T
L
A
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation