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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBX4
Full Name:
T-box transcription factor TBX4
Alias:
Type:
Mass (Da):
60204
Number AA:
545
UniProt ID:
P57082
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
L
Q
D
K
G
L
S
E
S
E
E
A
F
R
Site 2
S10
Q
D
K
G
L
S
E
S
E
E
A
F
R
A
P
Site 3
S46
L
S
G
A
A
L
G
S
P
P
G
P
G
A
D
Site 4
S99
A
G
R
R
M
F
P
S
Y
K
V
K
V
T
G
Site 5
Y100
G
R
R
M
F
P
S
Y
K
V
K
V
T
G
M
Site 6
Y149
P
A
M
P
G
R
L
Y
V
H
P
D
S
P
A
Site 7
S154
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Site 8
T174
S
F
Q
K
L
K
L
T
N
N
H
L
D
P
F
Site 9
Y192
I
L
N
S
M
H
K
Y
Q
P
R
L
H
I
V
Site 10
S226
F
P
E
T
S
F
I
S
V
T
S
Y
Q
N
H
Site 11
Y230
S
F
I
S
V
T
S
Y
Q
N
H
K
I
T
Q
Site 12
S252
F
A
K
G
F
R
G
S
D
D
S
D
L
R
V
Site 13
S255
G
F
R
G
S
D
D
S
D
L
R
V
A
R
L
Site 14
S264
L
R
V
A
R
L
Q
S
K
E
Y
P
V
I
S
Site 15
Y267
A
R
L
Q
S
K
E
Y
P
V
I
S
K
S
I
Site 16
S273
E
Y
P
V
I
S
K
S
I
M
R
Q
R
L
I
Site 17
S281
I
M
R
Q
R
L
I
S
P
Q
L
S
A
T
P
Site 18
S285
R
L
I
S
P
Q
L
S
A
T
P
D
V
G
P
Site 19
Y303
T
H
Q
A
L
Q
H
Y
Q
H
E
N
G
A
H
Site 20
S311
Q
H
E
N
G
A
H
S
Q
L
A
E
P
Q
D
Site 21
S322
E
P
Q
D
L
P
L
S
T
F
P
T
Q
R
D
Site 22
T323
P
Q
D
L
P
L
S
T
F
P
T
Q
R
D
S
Site 23
T326
L
P
L
S
T
F
P
T
Q
R
D
S
S
L
F
Site 24
S330
T
F
P
T
Q
R
D
S
S
L
F
Y
H
C
L
Site 25
S331
F
P
T
Q
R
D
S
S
L
F
Y
H
C
L
K
Site 26
Y334
Q
R
D
S
S
L
F
Y
H
C
L
K
R
R
D
Site 27
T343
C
L
K
R
R
D
G
T
R
H
L
D
L
P
C
Site 28
S353
L
D
L
P
C
K
R
S
Y
L
E
A
P
S
S
Site 29
Y354
D
L
P
C
K
R
S
Y
L
E
A
P
S
S
V
Site 30
S359
R
S
Y
L
E
A
P
S
S
V
G
E
D
H
Y
Site 31
S360
S
Y
L
E
A
P
S
S
V
G
E
D
H
Y
F
Site 32
Y366
S
S
V
G
E
D
H
Y
F
R
S
P
P
P
Y
Site 33
S369
G
E
D
H
Y
F
R
S
P
P
P
Y
D
Q
Q
Site 34
Y373
Y
F
R
S
P
P
P
Y
D
Q
Q
M
L
S
P
Site 35
S379
P
Y
D
Q
Q
M
L
S
P
S
Y
C
S
E
V
Site 36
S381
D
Q
Q
M
L
S
P
S
Y
C
S
E
V
T
P
Site 37
Y382
Q
Q
M
L
S
P
S
Y
C
S
E
V
T
P
R
Site 38
T387
P
S
Y
C
S
E
V
T
P
R
E
A
C
M
Y
Site 39
Y394
T
P
R
E
A
C
M
Y
S
G
S
G
P
E
I
Site 40
S395
P
R
E
A
C
M
Y
S
G
S
G
P
E
I
A
Site 41
S416
D
L
P
P
P
P
L
S
C
N
M
W
T
S
V
Site 42
Y426
M
W
T
S
V
S
P
Y
T
S
Y
S
V
Q
T
Site 43
S428
T
S
V
S
P
Y
T
S
Y
S
V
Q
T
M
E
Site 44
S430
V
S
P
Y
T
S
Y
S
V
Q
T
M
E
T
V
Site 45
T436
Y
S
V
Q
T
M
E
T
V
P
Y
Q
P
F
P
Site 46
Y439
Q
T
M
E
T
V
P
Y
Q
P
F
P
T
H
F
Site 47
T450
P
T
H
F
T
A
T
T
M
M
P
R
L
P
T
Site 48
T457
T
M
M
P
R
L
P
T
L
S
A
Q
S
S
Q
Site 49
S459
M
P
R
L
P
T
L
S
A
Q
S
S
Q
P
P
Site 50
S463
P
T
L
S
A
Q
S
S
Q
P
P
G
N
A
H
Site 51
S472
P
P
G
N
A
H
F
S
V
Y
N
Q
L
S
Q
Site 52
Y474
G
N
A
H
F
S
V
Y
N
Q
L
S
Q
S
Q
Site 53
S478
F
S
V
Y
N
Q
L
S
Q
S
Q
V
R
E
R
Site 54
S480
V
Y
N
Q
L
S
Q
S
Q
V
R
E
R
G
P
Site 55
S488
Q
V
R
E
R
G
P
S
A
S
F
P
R
E
R
Site 56
S490
R
E
R
G
P
S
A
S
F
P
R
E
R
G
L
Site 57
S507
G
C
E
R
K
P
P
S
P
H
L
N
A
A
N
Site 58
Y518
N
A
A
N
E
F
L
Y
S
Q
T
F
S
L
S
Site 59
S519
A
A
N
E
F
L
Y
S
Q
T
F
S
L
S
R
Site 60
T521
N
E
F
L
Y
S
Q
T
F
S
L
S
R
E
S
Site 61
S523
F
L
Y
S
Q
T
F
S
L
S
R
E
S
S
L
Site 62
S525
Y
S
Q
T
F
S
L
S
R
E
S
S
L
Q
Y
Site 63
S528
T
F
S
L
S
R
E
S
S
L
Q
Y
H
S
G
Site 64
S529
F
S
L
S
R
E
S
S
L
Q
Y
H
S
G
M
Site 65
Y532
S
R
E
S
S
L
Q
Y
H
S
G
M
G
T
V
Site 66
T538
Q
Y
H
S
G
M
G
T
V
E
N
W
T
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation