KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
WDR4
Full Name:
tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
Alias:
TRM82; WD repeat domain 4; WD repeat protein 4
Type:
Mass (Da):
45490
Number AA:
412
UniProt ID:
P57081
International Prot ID:
IPI00025718
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006400
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
G
G
S
R
F
L
A
T
S
I
A
S
S
D
D
Site 2
S26
G
S
R
F
L
A
T
S
I
A
S
S
D
D
D
Site 3
S34
I
A
S
S
D
D
D
S
L
F
I
Y
D
C
S
Site 4
Y38
D
D
D
S
L
F
I
Y
D
C
S
A
A
E
K
Site 5
S41
S
L
F
I
Y
D
C
S
A
A
E
K
K
S
Q
Site 6
S47
C
S
A
A
E
K
K
S
Q
E
N
K
G
E
D
Site 7
T68
S
G
A
I
L
A
S
T
F
S
K
S
G
S
Y
Site 8
S74
S
T
F
S
K
S
G
S
Y
F
A
L
T
D
D
Site 9
T79
S
G
S
Y
F
A
L
T
D
D
S
K
R
L
I
Site 10
S82
Y
F
A
L
T
D
D
S
K
R
L
I
L
F
R
Site 11
T90
K
R
L
I
L
F
R
T
K
P
W
Q
C
L
S
Site 12
S97
T
K
P
W
Q
C
L
S
V
R
T
V
A
R
R
Site 13
T109
A
R
R
C
T
A
L
T
F
I
A
S
E
E
K
Site 14
S123
K
V
L
V
A
D
K
S
G
D
V
Y
S
F
S
Site 15
Y127
A
D
K
S
G
D
V
Y
S
F
S
V
L
E
P
Site 16
S128
D
K
S
G
D
V
Y
S
F
S
V
L
E
P
H
Site 17
S130
S
G
D
V
Y
S
F
S
V
L
E
P
H
G
C
Site 18
T162
P
D
D
R
F
I
L
T
A
D
R
D
E
K
I
Site 19
S172
R
D
E
K
I
R
V
S
W
A
A
A
P
H
S
Site 20
S182
A
A
P
H
S
I
E
S
F
C
L
G
H
T
E
Site 21
T188
E
S
F
C
L
G
H
T
E
F
V
S
R
I
S
Site 22
S195
T
E
F
V
S
R
I
S
V
V
P
T
Q
P
G
Site 23
S206
T
Q
P
G
L
L
L
S
S
S
G
D
G
T
L
Site 24
S207
Q
P
G
L
L
L
S
S
S
G
D
G
T
L
R
Site 25
T212
L
S
S
S
G
D
G
T
L
R
L
W
E
Y
R
Site 26
Y218
G
T
L
R
L
W
E
Y
R
S
G
R
Q
L
H
Site 27
Y282
A
R
R
Q
Q
L
V
Y
R
Q
Q
L
A
F
Q
Site 28
Y317
Q
E
A
P
L
V
L
Y
R
P
V
G
D
Q
W
Site 29
S326
P
V
G
D
Q
W
Q
S
V
P
E
S
T
V
L
Site 30
S330
Q
W
Q
S
V
P
E
S
T
V
L
K
K
V
S
Site 31
S356
G
S
A
G
A
D
A
S
F
S
S
L
Y
K
A
Site 32
S358
A
G
A
D
A
S
F
S
S
L
Y
K
A
T
F
Site 33
S359
G
A
D
A
S
F
S
S
L
Y
K
A
T
F
D
Site 34
Y361
D
A
S
F
S
S
L
Y
K
A
T
F
D
N
V
Site 35
T364
F
S
S
L
Y
K
A
T
F
D
N
V
T
S
Y
Site 36
Y371
T
F
D
N
V
T
S
Y
L
K
K
K
E
E
R
Site 37
S391
E
K
K
Q
R
R
R
S
P
P
P
G
P
D
G
Site 38
S411
R
P
G
E
A
T
L
S
C
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation