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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STS2
Full Name:
Ubiquitin-associated and SH3 domain-containing protein A
Alias:
Cbl-interacting protein 4; CLIP4; STS-2; Suppressor of T-cell receptor signalling 2; T-cell ubiquitin ligand; TULA; UBASH3A; UBS3A
Type:
Protease complex protein, 26S protease
Mass (Da):
74123
Number AA:
661
UniProt ID:
P57075
International Prot ID:
IPI00025707
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
A
G
E
T
Q
L
Y
A
K
V
S
N
K
L
Site 2
S13
T
Q
L
Y
A
K
V
S
N
K
L
K
S
R
S
Site 3
S18
K
V
S
N
K
L
K
S
R
S
S
P
S
L
L
Site 4
S20
S
N
K
L
K
S
R
S
S
P
S
L
L
E
P
Site 5
S21
N
K
L
K
S
R
S
S
P
S
L
L
E
P
L
Site 6
S23
L
K
S
R
S
S
P
S
L
L
E
P
L
L
A
Site 7
T49
L
A
A
T
G
R
K
T
A
E
E
A
L
A
W
Site 8
T118
V
T
L
C
D
F
F
T
C
E
D
Q
K
V
E
Site 9
Y128
D
Q
K
V
E
C
L
Y
E
A
L
K
R
A
G
Site 10
T144
R
L
L
G
S
F
P
T
A
V
P
L
A
L
H
Site 11
S195
V
S
R
F
W
I
F
S
Q
V
P
G
H
G
P
Site 12
S207
H
G
P
N
L
R
L
S
N
L
T
R
A
S
F
Site 13
T210
N
L
R
L
S
N
L
T
R
A
S
F
V
S
H
Site 14
S216
L
T
R
A
S
F
V
S
H
Y
I
L
Q
K
Y
Site 15
Y218
R
A
S
F
V
S
H
Y
I
L
Q
K
Y
C
S
Site 16
Y223
S
H
Y
I
L
Q
K
Y
C
S
V
K
P
C
T
Site 17
T230
Y
C
S
V
K
P
C
T
K
Q
L
H
L
T
L
Site 18
T236
C
T
K
Q
L
H
L
T
L
A
H
K
F
Y
P
Site 19
Y242
L
T
L
A
H
K
F
Y
P
H
H
Q
R
T
L
Site 20
T265
L
G
H
S
C
Q
W
T
A
A
L
Y
S
R
D
Site 21
Y269
C
Q
W
T
A
A
L
Y
S
R
D
M
R
F
V
Site 22
Y278
R
D
M
R
F
V
H
Y
Q
T
L
R
A
L
F
Site 23
T280
M
R
F
V
H
Y
Q
T
L
R
A
L
F
Q
Y
Site 24
Y287
T
L
R
A
L
F
Q
Y
K
P
Q
N
V
D
E
Site 25
T296
P
Q
N
V
D
E
L
T
L
S
P
G
D
Y
I
Site 26
T308
D
Y
I
F
V
D
P
T
Q
Q
D
E
A
S
E
Site 27
S314
P
T
Q
Q
D
E
A
S
E
G
W
V
I
G
I
Site 28
Y335
R
G
F
L
P
E
N
Y
T
D
R
A
S
E
S
Site 29
T336
G
F
L
P
E
N
Y
T
D
R
A
S
E
S
D
Site 30
S340
E
N
Y
T
D
R
A
S
E
S
D
T
W
V
K
Site 31
S342
Y
T
D
R
A
S
E
S
D
T
W
V
K
H
R
Site 32
T344
D
R
A
S
E
S
D
T
W
V
K
H
R
M
Y
Site 33
Y351
T
W
V
K
H
R
M
Y
T
F
S
L
A
T
D
Site 34
T352
W
V
K
H
R
M
Y
T
F
S
L
A
T
D
L
Site 35
S354
K
H
R
M
Y
T
F
S
L
A
T
D
L
N
S
Site 36
S361
S
L
A
T
D
L
N
S
R
K
D
G
E
A
S
Site 37
S368
S
R
K
D
G
E
A
S
S
R
C
S
G
E
F
Site 38
S369
R
K
D
G
E
A
S
S
R
C
S
G
E
F
L
Site 39
S372
G
E
A
S
S
R
C
S
G
E
F
L
P
Q
T
Site 40
T379
S
G
E
F
L
P
Q
T
A
R
S
L
S
S
L
Site 41
S384
P
Q
T
A
R
S
L
S
S
L
Q
A
L
Q
A
Site 42
S420
K
A
W
L
Q
Q
C
S
T
P
D
G
K
Y
Y
Site 43
T421
A
W
L
Q
Q
C
S
T
P
D
G
K
Y
Y
R
Site 44
Y426
C
S
T
P
D
G
K
Y
Y
R
P
D
L
N
F
Site 45
Y427
S
T
P
D
G
K
Y
Y
R
P
D
L
N
F
P
Site 46
S436
P
D
L
N
F
P
C
S
L
P
R
R
S
R
G
Site 47
S441
P
C
S
L
P
R
R
S
R
G
I
K
D
F
E
Site 48
S454
F
E
N
D
P
P
L
S
S
C
G
I
F
Q
S
Site 49
S455
E
N
D
P
P
L
S
S
C
G
I
F
Q
S
R
Site 50
S477
D
S
G
I
R
I
S
S
V
F
A
S
P
A
L
Site 51
T522
T
K
W
E
A
G
K
T
T
P
T
L
M
S
L
Site 52
T523
K
W
E
A
G
K
T
T
P
T
L
M
S
L
E
Site 53
S528
K
T
T
P
T
L
M
S
L
E
E
L
K
E
A
Site 54
T541
E
A
N
F
N
I
D
T
D
Y
R
P
A
F
P
Site 55
Y543
N
F
N
I
D
T
D
Y
R
P
A
F
P
L
S
Site 56
S550
Y
R
P
A
F
P
L
S
A
L
M
P
A
E
S
Site 57
S557
S
A
L
M
P
A
E
S
Y
Q
E
Y
M
D
R
Site 58
Y561
P
A
E
S
Y
Q
E
Y
M
D
R
C
T
A
S
Site 59
T591
L
I
V
S
H
G
S
T
L
D
S
C
T
R
P
Site 60
S594
S
H
G
S
T
L
D
S
C
T
R
P
L
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation