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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NRG3
Full Name:
Pro-neuregulin-3, membrane-bound isoform
Alias:
Neuregulin 3; Neuregulin-3; NRG-3; Pro-NRG3
Type:
Ligand, receptor tyrosine kinase
Mass (Da):
77900
Number AA:
UniProt ID:
P56975
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008083
GO:0030971
GO:0030297
PhosphoSite+
KinaseNET
Biological Process:
GO:0009790
GO:0001558
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S116
G
Q
D
P
F
F
L
S
K
P
S
S
F
P
K
Site 2
S119
P
F
F
L
S
K
P
S
S
F
P
K
A
M
E
Site 3
T156
R
T
P
N
R
I
S
T
R
L
T
T
I
T
R
Site 4
T278
S
P
K
F
H
T
T
T
Y
S
T
E
R
S
E
Site 5
Y357
F
M
E
S
E
E
V
Y
Q
R
Q
V
L
S
I
Site 6
Y382
G
M
F
C
A
A
F
Y
F
K
S
K
K
Q
A
Site 7
S404
K
V
P
Q
N
G
K
S
Y
S
L
K
A
S
S
Site 8
Y405
V
P
Q
N
G
K
S
Y
S
L
K
A
S
S
T
Site 9
S406
P
Q
N
G
K
S
Y
S
L
K
A
S
S
T
M
Site 10
S410
K
S
Y
S
L
K
A
S
S
T
M
A
K
S
E
Site 11
S411
S
Y
S
L
K
A
S
S
T
M
A
K
S
E
N
Site 12
T412
Y
S
L
K
A
S
S
T
M
A
K
S
E
N
L
Site 13
S416
A
S
S
T
M
A
K
S
E
N
L
V
K
S
H
Site 14
S422
K
S
E
N
L
V
K
S
H
V
Q
L
Q
N
Y
Site 15
Y429
S
H
V
Q
L
Q
N
Y
S
K
V
E
R
H
P
Site 16
S447
L
E
K
M
M
E
S
S
F
V
G
P
Q
S
F
Site 17
S453
S
S
F
V
G
P
Q
S
F
P
E
V
P
S
P
Site 18
S459
Q
S
F
P
E
V
P
S
P
D
R
G
S
Q
S
Site 19
S464
V
P
S
P
D
R
G
S
Q
S
V
K
H
H
R
Site 20
S466
S
P
D
R
G
S
Q
S
V
K
H
H
R
S
L
Site 21
S472
Q
S
V
K
H
H
R
S
L
S
S
C
C
S
P
Site 22
S474
V
K
H
H
R
S
L
S
S
C
C
S
P
G
Q
Site 23
S475
K
H
H
R
S
L
S
S
C
C
S
P
G
Q
R
Site 24
S478
R
S
L
S
S
C
C
S
P
G
Q
R
S
G
M
Site 25
T494
H
R
N
A
F
R
R
T
P
P
S
P
R
S
R
Site 26
S497
A
F
R
R
T
P
P
S
P
R
S
R
L
G
G
Site 27
S500
R
T
P
P
S
P
R
S
R
L
G
G
I
V
G
Site 28
Y510
G
G
I
V
G
P
A
Y
Q
Q
L
E
E
S
R
Site 29
T523
S
R
I
P
D
Q
D
T
I
P
C
Q
G
I
E
Site 30
T534
Q
G
I
E
V
R
K
T
I
S
H
L
P
I
Q
Site 31
Y553
E
R
P
L
D
L
K
Y
S
S
S
G
L
K
T
Site 32
S554
R
P
L
D
L
K
Y
S
S
S
G
L
K
T
Q
Site 33
S556
L
D
L
K
Y
S
S
S
G
L
K
T
Q
R
N
Site 34
T560
Y
S
S
S
G
L
K
T
Q
R
N
T
S
I
N
Site 35
T564
G
L
K
T
Q
R
N
T
S
I
N
M
Q
L
P
Site 36
S565
L
K
T
Q
R
N
T
S
I
N
M
Q
L
P
S
Site 37
S572
S
I
N
M
Q
L
P
S
R
E
T
N
P
Y
F
Site 38
T575
M
Q
L
P
S
R
E
T
N
P
Y
F
N
S
L
Site 39
Y578
P
S
R
E
T
N
P
Y
F
N
S
L
E
Q
K
Site 40
S591
Q
K
D
L
V
G
Y
S
S
T
R
A
S
S
V
Site 41
S592
K
D
L
V
G
Y
S
S
T
R
A
S
S
V
P
Site 42
S596
G
Y
S
S
T
R
A
S
S
V
P
I
I
P
S
Site 43
T609
P
S
V
G
L
E
E
T
C
L
Q
M
P
G
I
Site 44
S621
P
G
I
S
E
V
K
S
I
K
W
C
K
N
S
Site 45
T666
Q
E
Q
I
R
I
L
T
D
A
R
R
S
E
D
Site 46
S671
I
L
T
D
A
R
R
S
E
D
Y
E
L
A
S
Site 47
Y674
D
A
R
R
S
E
D
Y
E
L
A
S
V
E
T
Site 48
S678
S
E
D
Y
E
L
A
S
V
E
T
E
D
S
A
Site 49
S684
A
S
V
E
T
E
D
S
A
S
E
N
T
A
F
Site 50
S686
V
E
T
E
D
S
A
S
E
N
T
A
F
L
P
Site 51
S695
N
T
A
F
L
P
L
S
P
T
A
K
S
E
R
Site 52
S700
P
L
S
P
T
A
K
S
E
R
E
A
Q
F
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation