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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRSS12
Full Name:
Neurotrypsin
Alias:
Bssp3; Bssp-3; EC 3.4.21.-; Mgc12722; Mrt1; Netr; Protease, serine, 12 (neurotrypsin, motopsin); Prss12
Type:
Protease
Mass (Da):
97012
Number AA:
875
UniProt ID:
P56730
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005044
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
F
D
S
V
L
N
D
S
L
H
H
S
H
R
H
Site 2
S32
L
N
D
S
L
H
H
S
H
R
H
S
P
P
A
Site 3
S36
L
H
H
S
H
R
H
S
P
P
A
G
P
H
Y
Site 4
Y43
S
P
P
A
G
P
H
Y
P
Y
Y
L
P
T
Q
Site 5
Y45
P
A
G
P
H
Y
P
Y
Y
L
P
T
Q
Q
R
Site 6
Y46
A
G
P
H
Y
P
Y
Y
L
P
T
Q
Q
R
P
Site 7
T49
H
Y
P
Y
Y
L
P
T
Q
Q
R
P
P
R
T
Site 8
T56
T
Q
Q
R
P
P
R
T
R
P
P
P
P
L
P
Site 9
T85
H
A
L
Q
A
G
H
T
P
R
P
H
P
W
G
Site 10
S101
P
A
G
E
P
W
V
S
V
T
D
F
G
A
P
Site 11
S122
V
P
P
F
L
E
R
S
P
P
A
S
W
A
Q
Site 12
S126
L
E
R
S
P
P
A
S
W
A
Q
L
R
G
Q
Site 13
S140
Q
R
H
N
F
C
R
S
P
D
G
A
G
R
P
Site 14
Y151
A
G
R
P
W
C
F
Y
G
D
A
R
G
K
V
Site 15
Y162
R
G
K
V
D
W
G
Y
C
D
C
R
H
G
S
Site 16
S169
Y
C
D
C
R
H
G
S
V
R
L
R
G
G
K
Site 17
T182
G
K
N
E
F
E
G
T
V
E
V
Y
A
S
G
Site 18
T222
G
K
G
I
A
K
Q
T
P
F
S
G
L
G
L
Site 19
T268
Q
K
M
A
A
A
V
T
C
S
F
S
H
G
P
Site 20
S287
I
R
L
A
G
G
S
S
V
H
E
G
R
V
E
Site 21
Y296
H
E
G
R
V
E
L
Y
H
A
G
Q
W
G
T
Site 22
Y334
A
K
A
W
H
Q
A
Y
F
G
E
G
S
G
P
Site 23
T350
M
L
D
E
V
R
C
T
G
N
E
L
S
I
E
Site 24
S355
R
C
T
G
N
E
L
S
I
E
Q
C
P
K
S
Site 25
S395
R
L
A
G
G
K
G
S
H
E
G
R
L
E
V
Site 26
Y403
H
E
G
R
L
E
V
Y
Y
R
G
Q
W
G
T
Site 27
Y404
E
G
R
L
E
V
Y
Y
R
G
Q
W
G
T
V
Site 28
Y422
G
W
T
E
L
N
T
Y
V
V
C
R
Q
L
G
Site 29
Y432
C
R
Q
L
G
F
K
Y
G
K
Q
A
S
A
N
Site 30
S437
F
K
Y
G
K
Q
A
S
A
N
H
F
E
E
S
Site 31
S454
P
I
W
L
D
D
V
S
C
S
G
K
E
T
R
Site 32
T460
V
S
C
S
G
K
E
T
R
F
L
Q
C
S
R
Site 33
Y486
E
D
V
S
I
A
C
Y
P
G
G
E
G
H
R
Site 34
S495
G
G
E
G
H
R
L
S
L
G
F
P
V
R
L
Site 35
Y543
V
I
C
R
Q
L
G
Y
K
G
P
A
R
A
R
Site 36
T551
K
G
P
A
R
A
R
T
M
A
Y
F
G
E
G
Site 37
Y554
A
R
A
R
T
M
A
Y
F
G
E
G
K
G
P
Site 38
S575
K
C
T
G
N
E
R
S
L
A
D
C
I
K
Q
Site 39
Y601
D
A
G
V
I
C
D
Y
F
G
K
K
A
S
G
Site 40
S610
G
K
K
A
S
G
N
S
N
K
E
S
L
S
S
Site 41
S614
S
G
N
S
N
K
E
S
L
S
S
V
C
G
L
Site 42
S616
N
S
N
K
E
S
L
S
S
V
C
G
L
R
L
Site 43
S617
S
N
K
E
S
L
S
S
V
C
G
L
R
L
L
Site 44
S637
R
I
I
G
G
K
N
S
L
R
G
G
W
P
W
Site 45
S647
G
G
W
P
W
Q
V
S
L
R
L
K
S
S
H
Site 46
S652
Q
V
S
L
R
L
K
S
S
H
G
D
G
R
L
Site 47
S653
V
S
L
R
L
K
S
S
H
G
D
G
R
L
L
Site 48
Y681
A
A
H
C
F
K
R
Y
G
N
S
T
R
S
Y
Site 49
S684
C
F
K
R
Y
G
N
S
T
R
S
Y
A
V
R
Site 50
T685
F
K
R
Y
G
N
S
T
R
S
Y
A
V
R
V
Site 51
S687
R
Y
G
N
S
T
R
S
Y
A
V
R
V
G
D
Site 52
Y688
Y
G
N
S
T
R
S
Y
A
V
R
V
G
D
Y
Site 53
Y695
Y
A
V
R
V
G
D
Y
H
T
L
V
P
E
E
Site 54
T697
V
R
V
G
D
Y
H
T
L
V
P
E
E
F
E
Site 55
Y718
Q
I
V
I
H
R
E
Y
R
P
D
R
S
D
Y
Site 56
S723
R
E
Y
R
P
D
R
S
D
Y
D
I
A
L
V
Site 57
Y725
Y
R
P
D
R
S
D
Y
D
I
A
L
V
R
L
Site 58
S743
E
E
Q
C
A
R
F
S
S
H
V
L
P
A
C
Site 59
Y766
Q
K
T
A
S
N
C
Y
I
T
G
W
G
D
T
Site 60
T773
Y
I
T
G
W
G
D
T
G
R
A
Y
S
R
T
Site 61
Y777
W
G
D
T
G
R
A
Y
S
R
T
L
Q
Q
A
Site 62
S778
G
D
T
G
R
A
Y
S
R
T
L
Q
Q
A
A
Site 63
T780
T
G
R
A
Y
S
R
T
L
Q
Q
A
A
I
P
Site 64
Y798
K
R
F
C
E
E
R
Y
K
G
R
F
T
G
R
Site 65
T803
E
R
Y
K
G
R
F
T
G
R
M
L
C
A
G
Site 66
S820
H
E
H
K
R
V
D
S
C
Q
G
D
S
G
G
Site 67
Y841
P
G
E
S
W
V
V
Y
G
V
T
S
W
G
Y
Site 68
Y848
Y
G
V
T
S
W
G
Y
G
C
G
V
K
D
S
Site 69
S855
Y
G
C
G
V
K
D
S
P
G
V
Y
T
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation