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Updated November 2019
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Protein Info
Short Name:
Per3
Full Name:
Period circadian protein homolog 3
Alias:
GIG13; Growth-inhibiting 13; Period 3; Period circadian 3
Type:
Cytoplasm, Nucleus protein
Mass (Da):
131872
Number AA:
1201
UniProt ID:
P56645
International Prot ID:
IPI00010692
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0048511
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
D
E
A
L
G
E
E
S
G
E
R
W
S
P
E
Site 2
S28
E
E
S
G
E
R
W
S
P
E
F
H
L
Q
R
Site 3
S40
L
Q
R
K
L
A
D
S
S
H
S
E
Q
Q
D
Site 4
S52
Q
Q
D
R
N
R
V
S
E
E
L
I
M
V
V
Site 5
Y65
V
V
Q
E
M
K
K
Y
F
P
S
E
R
R
N
Site 6
S68
E
M
K
K
Y
F
P
S
E
R
R
N
K
P
S
Site 7
S75
S
E
R
R
N
K
P
S
T
L
D
A
L
N
Y
Site 8
T76
E
R
R
N
K
P
S
T
L
D
A
L
N
Y
A
Site 9
S89
Y
A
L
R
C
V
H
S
V
Q
A
N
S
E
F
Site 10
S101
S
E
F
F
Q
I
L
S
Q
N
G
A
P
Q
A
Site 11
S111
G
A
P
Q
A
D
V
S
M
Y
S
L
E
E
L
Site 12
T120
Y
S
L
E
E
L
A
T
I
A
S
E
H
T
S
Site 13
S123
E
E
L
A
T
I
A
S
E
H
T
S
K
N
T
Site 14
S127
T
I
A
S
E
H
T
S
K
N
T
D
T
F
V
Site 15
T132
H
T
S
K
N
T
D
T
F
V
A
V
F
S
F
Site 16
Y180
P
Q
D
M
R
V
F
Y
A
H
T
A
R
A
Q
Site 17
S226
R
K
Q
E
K
C
H
S
P
F
R
I
I
P
Y
Site 18
T253
E
S
E
P
C
C
L
T
V
V
E
K
I
H
S
Site 19
S260
T
V
V
E
K
I
H
S
G
Y
E
A
P
R
I
Site 20
Y262
V
E
K
I
H
S
G
Y
E
A
P
R
I
P
V
Site 21
T275
P
V
N
K
R
I
F
T
T
T
H
T
P
G
C
Site 22
T277
N
K
R
I
F
T
T
T
H
T
P
G
C
V
F
Site 23
S309
L
I
G
T
S
I
L
S
Y
L
H
P
E
D
R
Site 24
Y310
I
G
T
S
I
L
S
Y
L
H
P
E
D
R
S
Site 25
S317
Y
L
H
P
E
D
R
S
L
M
V
A
I
H
Q
Site 26
Y329
I
H
Q
K
V
L
K
Y
A
G
H
P
P
F
E
Site 27
S338
G
H
P
P
F
E
H
S
P
I
R
F
C
T
Q
Site 28
T344
H
S
P
I
R
F
C
T
Q
N
G
D
Y
I
I
Site 29
Y349
F
C
T
Q
N
G
D
Y
I
I
L
D
S
S
W
Site 30
S354
G
D
Y
I
I
L
D
S
S
W
S
S
F
V
N
Site 31
S355
D
Y
I
I
L
D
S
S
W
S
S
F
V
N
P
Site 32
S357
I
I
L
D
S
S
W
S
S
F
V
N
P
W
S
Site 33
S358
I
L
D
S
S
W
S
S
F
V
N
P
W
S
R
Site 34
S368
N
P
W
S
R
K
I
S
F
I
I
G
R
H
K
Site 35
T378
I
G
R
H
K
V
R
T
S
P
L
N
E
D
V
Site 36
S379
G
R
H
K
V
R
T
S
P
L
N
E
D
V
F
Site 37
T388
L
N
E
D
V
F
A
T
K
I
K
K
M
N
D
Site 38
T401
N
D
N
D
K
D
I
T
E
L
Q
E
Q
I
Y
Site 39
Y408
T
E
L
Q
E
Q
I
Y
K
L
L
L
Q
P
V
Site 40
S420
Q
P
V
H
V
S
V
S
S
G
Y
G
S
L
G
Site 41
Y423
H
V
S
V
S
S
G
Y
G
S
L
G
S
S
G
Site 42
S425
S
V
S
S
G
Y
G
S
L
G
S
S
G
S
Q
Site 43
S428
S
G
Y
G
S
L
G
S
S
G
S
Q
E
Q
L
Site 44
S429
G
Y
G
S
L
G
S
S
G
S
Q
E
Q
L
V
Site 45
S431
G
S
L
G
S
S
G
S
Q
E
Q
L
V
S
I
Site 46
S437
G
S
Q
E
Q
L
V
S
I
A
S
S
S
E
A
Site 47
S440
E
Q
L
V
S
I
A
S
S
S
E
A
S
G
H
Site 48
S441
Q
L
V
S
I
A
S
S
S
E
A
S
G
H
R
Site 49
S445
I
A
S
S
S
E
A
S
G
H
R
V
E
E
T
Site 50
Y463
Q
M
T
L
Q
Q
V
Y
A
S
V
N
K
I
K
Site 51
Y477
K
N
L
G
Q
Q
L
Y
I
E
S
M
T
K
S
Site 52
S480
G
Q
Q
L
Y
I
E
S
M
T
K
S
S
F
K
Site 53
S484
Y
I
E
S
M
T
K
S
S
F
K
P
V
T
G
Site 54
S485
I
E
S
M
T
K
S
S
F
K
P
V
T
G
T
Site 55
T490
K
S
S
F
K
P
V
T
G
T
R
T
E
P
N
Site 56
T504
N
G
G
G
E
C
K
T
F
T
S
F
H
Q
T
Site 57
T511
T
F
T
S
F
H
Q
T
L
K
N
N
S
V
Y
Site 58
Y518
T
L
K
N
N
S
V
Y
T
E
P
C
E
D
L
Site 59
S531
D
L
R
N
D
E
H
S
P
S
Y
Q
Q
I
N
Site 60
Y534
N
D
E
H
S
P
S
Y
Q
Q
I
N
C
I
D
Site 61
S549
S
V
I
R
Y
L
K
S
Y
N
I
P
A
L
K
Site 62
Y550
V
I
R
Y
L
K
S
Y
N
I
P
A
L
K
R
Site 63
S561
A
L
K
R
K
C
I
S
C
T
N
T
T
S
S
Site 64
T563
K
R
K
C
I
S
C
T
N
T
T
S
S
S
S
Site 65
T565
K
C
I
S
C
T
N
T
T
S
S
S
S
E
E
Site 66
S567
I
S
C
T
N
T
T
S
S
S
S
E
E
D
K
Site 67
S568
S
C
T
N
T
T
S
S
S
S
E
E
D
K
Q
Site 68
S570
T
N
T
T
S
S
S
S
E
E
D
K
Q
N
H
Site 69
S597
Q
I
P
A
I
P
K
S
E
M
P
T
N
G
R
Site 70
T601
I
P
K
S
E
M
P
T
N
G
R
S
I
D
T
Site 71
S605
E
M
P
T
N
G
R
S
I
D
T
G
G
G
A
Site 72
S628
L
S
L
G
S
G
I
S
Q
C
G
Y
S
S
T
Site 73
T635
S
Q
C
G
Y
S
S
T
I
V
H
V
P
P
P
Site 74
T644
V
H
V
P
P
P
E
T
A
R
D
A
T
L
F
Site 75
T649
P
E
T
A
R
D
A
T
L
F
C
E
P
W
T
Site 76
T665
N
M
Q
P
A
P
L
T
S
E
E
F
K
H
V
Site 77
S666
M
Q
P
A
P
L
T
S
E
E
F
K
H
V
G
Site 78
Y690
T
Q
K
E
E
Q
N
Y
V
D
K
F
R
E
K
Site 79
S700
K
F
R
E
K
I
L
S
S
P
Y
S
S
Y
L
Site 80
S701
F
R
E
K
I
L
S
S
P
Y
S
S
Y
L
Q
Site 81
S704
K
I
L
S
S
P
Y
S
S
Y
L
Q
Q
E
S
Site 82
S705
I
L
S
S
P
Y
S
S
Y
L
Q
Q
E
S
R
Site 83
Y706
L
S
S
P
Y
S
S
Y
L
Q
Q
E
S
R
S
Site 84
S711
S
S
Y
L
Q
Q
E
S
R
S
K
A
K
Y
S
Site 85
Y717
E
S
R
S
K
A
K
Y
S
Y
F
Q
G
D
S
Site 86
S718
S
R
S
K
A
K
Y
S
Y
F
Q
G
D
S
T
Site 87
Y719
R
S
K
A
K
Y
S
Y
F
Q
G
D
S
T
S
Site 88
S724
Y
S
Y
F
Q
G
D
S
T
S
K
Q
T
R
S
Site 89
S726
Y
F
Q
G
D
S
T
S
K
Q
T
R
S
A
G
Site 90
S750
K
L
P
E
P
P
D
S
S
S
S
N
T
G
S
Site 91
S751
L
P
E
P
P
D
S
S
S
S
N
T
G
S
G
Site 92
S752
P
E
P
P
D
S
S
S
S
N
T
G
S
G
P
Site 93
S753
E
P
P
D
S
S
S
S
N
T
G
S
G
P
R
Site 94
T755
P
D
S
S
S
S
N
T
G
S
G
P
R
R
G
Site 95
S757
S
S
S
S
N
T
G
S
G
P
R
R
G
A
H
Site 96
S773
N
A
Q
P
C
C
P
S
A
A
S
S
P
H
T
Site 97
S776
P
C
C
P
S
A
A
S
S
P
H
T
S
S
P
Site 98
S777
C
C
P
S
A
A
S
S
P
H
T
S
S
P
T
Site 99
T780
S
A
A
S
S
P
H
T
S
S
P
T
F
P
P
Site 100
S781
A
A
S
S
P
H
T
S
S
P
T
F
P
P
A
Site 101
S782
A
S
S
P
H
T
S
S
P
T
F
P
P
A
A
Site 102
T784
S
P
H
T
S
S
P
T
F
P
P
A
A
M
V
Site 103
S809
F
P
L
P
A
A
T
S
P
G
R
E
Y
A
A
Site 104
Y814
A
T
S
P
G
R
E
Y
A
A
P
G
T
A
P
Site 105
T819
R
E
Y
A
A
P
G
T
A
P
E
G
L
H
G
Site 106
S830
G
L
H
G
P
P
L
S
E
G
L
Q
P
Y
P
Site 107
Y836
L
S
E
G
L
Q
P
Y
P
A
F
P
F
P
Y
Site 108
S882
A
S
S
A
I
S
P
S
M
S
S
A
M
S
P
Site 109
S885
A
I
S
P
S
M
S
S
A
M
S
P
T
L
D
Site 110
S888
P
S
M
S
S
A
M
S
P
T
L
D
P
P
P
Site 111
T890
M
S
S
A
M
S
P
T
L
D
P
P
P
S
V
Site 112
S896
P
T
L
D
P
P
P
S
V
T
S
Q
R
R
E
Site 113
S899
D
P
P
P
S
V
T
S
Q
R
R
E
E
E
K
Site 114
T918
S
E
G
H
P
F
I
T
S
R
S
S
S
P
L
Site 115
S919
E
G
H
P
F
I
T
S
R
S
S
S
P
L
Q
Site 116
S921
H
P
F
I
T
S
R
S
S
S
P
L
Q
L
N
Site 117
S922
P
F
I
T
S
R
S
S
S
P
L
Q
L
N
L
Site 118
S923
F
I
T
S
R
S
S
S
P
L
Q
L
N
L
L
Site 119
S938
Q
E
E
M
P
R
P
S
E
S
P
D
Q
M
R
Site 120
S940
E
M
P
R
P
S
E
S
P
D
Q
M
R
R
N
Site 121
T948
P
D
Q
M
R
R
N
T
C
P
Q
T
E
Y
C
Site 122
Y954
N
T
C
P
Q
T
E
Y
C
V
T
G
N
N
G
Site 123
T957
P
Q
T
E
Y
C
V
T
G
N
N
G
S
E
S
Site 124
S964
T
G
N
N
G
S
E
S
S
P
A
T
T
G
A
Site 125
S965
G
N
N
G
S
E
S
S
P
A
T
T
G
A
L
Site 126
T968
G
S
E
S
S
P
A
T
T
G
A
L
S
T
G
Site 127
T969
S
E
S
S
P
A
T
T
G
A
L
S
T
G
S
Site 128
S973
P
A
T
T
G
A
L
S
T
G
S
P
P
R
E
Site 129
S976
T
G
A
L
S
T
G
S
P
P
R
E
N
P
S
Site 130
S983
S
P
P
R
E
N
P
S
H
P
T
A
S
A
L
Site 131
S988
N
P
S
H
P
T
A
S
A
L
S
T
G
S
P
Site 132
S991
H
P
T
A
S
A
L
S
T
G
S
P
P
M
K
Site 133
T992
P
T
A
S
A
L
S
T
G
S
P
P
M
K
N
Site 134
S994
A
S
A
L
S
T
G
S
P
P
M
K
N
P
S
Site 135
S1001
S
P
P
M
K
N
P
S
H
P
T
A
S
A
L
Site 136
S1019
S
P
P
M
K
N
P
S
H
P
T
A
S
T
L
Site 137
S1024
N
P
S
H
P
T
A
S
T
L
S
M
G
L
P
Site 138
T1025
P
S
H
P
T
A
S
T
L
S
M
G
L
P
P
Site 139
S1027
H
P
T
A
S
T
L
S
M
G
L
P
P
S
R
Site 140
S1033
L
S
M
G
L
P
P
S
R
T
P
S
H
P
T
Site 141
T1035
M
G
L
P
P
S
R
T
P
S
H
P
T
A
T
Site 142
S1037
L
P
P
S
R
T
P
S
H
P
T
A
T
V
L
Site 143
T1042
T
P
S
H
P
T
A
T
V
L
S
T
G
S
P
Site 144
S1045
H
P
T
A
T
V
L
S
T
G
S
P
P
S
E
Site 145
T1046
P
T
A
T
V
L
S
T
G
S
P
P
S
E
S
Site 146
S1048
A
T
V
L
S
T
G
S
P
P
S
E
S
P
S
Site 147
S1051
L
S
T
G
S
P
P
S
E
S
P
S
R
T
G
Site 148
S1053
T
G
S
P
P
S
E
S
P
S
R
T
G
S
A
Site 149
S1055
S
P
P
S
E
S
P
S
R
T
G
S
A
A
S
Site 150
T1057
P
S
E
S
P
S
R
T
G
S
A
A
S
G
S
Site 151
S1059
E
S
P
S
R
T
G
S
A
A
S
G
S
S
D
Site 152
S1062
S
R
T
G
S
A
A
S
G
S
S
D
S
S
I
Site 153
S1064
T
G
S
A
A
S
G
S
S
D
S
S
I
Y
L
Site 154
S1065
G
S
A
A
S
G
S
S
D
S
S
I
Y
L
T
Site 155
S1067
A
A
S
G
S
S
D
S
S
I
Y
L
T
S
S
Site 156
S1068
A
S
G
S
S
D
S
S
I
Y
L
T
S
S
V
Site 157
Y1070
G
S
S
D
S
S
I
Y
L
T
S
S
V
Y
S
Site 158
T1072
S
D
S
S
I
Y
L
T
S
S
V
Y
S
S
K
Site 159
S1073
D
S
S
I
Y
L
T
S
S
V
Y
S
S
K
I
Site 160
S1074
S
S
I
Y
L
T
S
S
V
Y
S
S
K
I
S
Site 161
S1077
Y
L
T
S
S
V
Y
S
S
K
I
S
Q
N
G
Site 162
S1078
L
T
S
S
V
Y
S
S
K
I
S
Q
N
G
Q
Site 163
S1081
S
V
Y
S
S
K
I
S
Q
N
G
Q
Q
S
Q
Site 164
S1087
I
S
Q
N
G
Q
Q
S
Q
D
V
Q
K
K
E
Site 165
T1111
I
W
R
M
I
R
Q
T
P
E
R
I
L
M
T
Site 166
Y1119
P
E
R
I
L
M
T
Y
Q
V
P
E
R
V
K
Site 167
S1139
E
D
L
E
K
L
E
S
M
R
Q
Q
Q
P
Q
Site 168
S1148
R
Q
Q
Q
P
Q
F
S
H
G
Q
K
E
E
L
Site 169
T1168
W
I
Q
S
Q
T
V
T
Q
E
I
D
I
Q
A
Site 170
S1184
V
T
C
E
N
E
D
S
A
D
G
A
A
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation