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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPTE
Full Name:
Putative tyrosine-protein phosphatase TPTE
Alias:
BJ-HCC-5; Cancer/testis antigen 44; CT44; EC 3.1.3.48; PTEN2; PTEN-related tyrosine phosphatase; Putative tyrosine-protein phosphatase TPTE; Transmembrane phosphatase with tensiny; Tumor antigen BJ-HCC-5
Type:
EC 3.1.3.48; Receptor protein phosphatase, tyrosine
Mass (Da):
64306
Number AA:
551
UniProt ID:
P56180
International Prot ID:
IPI00215913
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
I
E
L
G
P
N
D
S
P
Q
T
S
E
F
K
Site 2
T25
G
P
N
D
S
P
Q
T
S
E
F
K
G
A
T
Site 3
S26
P
N
D
S
P
Q
T
S
E
F
K
G
A
T
E
Site 4
T32
T
S
E
F
K
G
A
T
E
E
A
P
A
K
E
Site 5
S40
E
E
A
P
A
K
E
S
P
H
T
S
E
F
K
Site 6
T43
P
A
K
E
S
P
H
T
S
E
F
K
G
A
A
Site 7
S44
A
K
E
S
P
H
T
S
E
F
K
G
A
A
R
Site 8
S58
R
V
S
P
I
S
E
S
V
L
A
R
L
S
K
Site 9
S64
E
S
V
L
A
R
L
S
K
F
E
V
E
D
A
Site 10
Y77
D
A
E
N
V
A
S
Y
D
S
K
I
K
K
I
Site 11
Y153
F
V
E
R
R
Q
Q
Y
F
S
D
L
F
N
I
Site 12
S155
E
R
R
Q
Q
Y
F
S
D
L
F
N
I
L
D
Site 13
T191
L
R
N
I
P
R
W
T
H
L
L
R
L
L
R
Site 14
S224
K
L
I
R
R
R
V
S
E
N
K
R
R
Y
T
Site 15
Y230
V
S
E
N
K
R
R
Y
T
R
D
G
F
D
L
Site 16
T231
S
E
N
K
R
R
Y
T
R
D
G
F
D
L
D
Site 17
S250
T
E
R
I
I
A
M
S
F
P
S
S
G
R
Q
Site 18
S254
I
A
M
S
F
P
S
S
G
R
Q
S
F
Y
R
Site 19
S258
F
P
S
S
G
R
Q
S
F
Y
R
N
P
I
K
Site 20
Y260
S
S
G
R
Q
S
F
Y
R
N
P
I
K
E
V
Site 21
Y279
D
K
K
H
R
N
H
Y
R
V
Y
N
L
C
S
Site 22
Y282
H
R
N
H
Y
R
V
Y
N
L
C
S
E
R
A
Site 23
S286
Y
R
V
Y
N
L
C
S
E
R
A
Y
D
P
K
Site 24
Y290
N
L
C
S
E
R
A
Y
D
P
K
H
F
H
N
Site 25
T342
A
I
H
C
K
G
G
T
D
R
T
G
T
M
V
Site 26
T345
C
K
G
G
T
D
R
T
G
T
M
V
C
A
F
Site 27
S356
V
C
A
F
L
I
A
S
E
I
C
S
T
A
K
Site 28
T361
I
A
S
E
I
C
S
T
A
K
E
S
L
Y
Y
Site 29
Y367
S
T
A
K
E
S
L
Y
Y
F
G
E
R
R
T
Site 30
Y368
T
A
K
E
S
L
Y
Y
F
G
E
R
R
T
D
Site 31
T374
Y
Y
F
G
E
R
R
T
D
K
T
H
S
E
K
Site 32
T377
G
E
R
R
T
D
K
T
H
S
E
K
F
Q
G
Site 33
S379
R
R
T
D
K
T
H
S
E
K
F
Q
G
V
K
Site 34
T387
E
K
F
Q
G
V
K
T
P
S
Q
K
R
Y
V
Site 35
S389
F
Q
G
V
K
T
P
S
Q
K
R
Y
V
A
Y
Site 36
Y393
K
T
P
S
Q
K
R
Y
V
A
Y
F
A
Q
V
Site 37
Y396
S
Q
K
R
Y
V
A
Y
F
A
Q
V
K
H
L
Site 38
Y404
F
A
Q
V
K
H
L
Y
N
W
N
L
P
P
R
Site 39
Y422
F
I
K
H
F
I
I
Y
S
I
P
R
Y
V
R
Site 40
S423
I
K
H
F
I
I
Y
S
I
P
R
Y
V
R
D
Site 41
Y427
I
I
Y
S
I
P
R
Y
V
R
D
L
K
I
Q
Site 42
S447
K
V
V
F
S
T
I
S
L
G
K
C
S
V
L
Site 43
T459
S
V
L
D
N
I
T
T
D
K
I
L
I
D
V
Site 44
Y473
V
F
D
G
P
P
L
Y
D
D
V
K
V
Q
F
Site 45
Y488
F
Y
S
N
L
P
T
Y
Y
D
N
C
S
F
Y
Site 46
Y489
Y
S
N
L
P
T
Y
Y
D
N
C
S
F
Y
F
Site 47
Y509
F
I
E
N
N
R
L
Y
L
P
K
N
E
L
D
Site 48
Y527
K
Q
K
A
R
R
I
Y
P
S
D
F
A
V
E
Site 49
S529
K
A
R
R
I
Y
P
S
D
F
A
V
E
I
L
Site 50
S544
F
G
E
K
M
T
S
S
D
V
V
A
G
S
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation