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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HADHB
Full Name:
Trifunctional enzyme subunit beta, mitochondrial
Alias:
Acetyl-CoA acyltransferase; Beta-ketothiolase; ECHB; Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein) beta subunit; MSTP029; TP-beta; Trifunctional enzyme beta subunit, mitochondrial precursor
Type:
Lipid Metabolism - fatty acid elongation in mitochondria; EC 2.3.1.16; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; Lipid Metabolism - fatty acid
Mass (Da):
51294
Number AA:
474
UniProt ID:
P55084
International Prot ID:
IPI00022793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0003857
GO:0003988
GO:0004300
PhosphoSite+
KinaseNET
Biological Process:
GO:0006635
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
S
K
W
A
L
R
F
S
I
R
P
L
S
C
S
Site 2
S27
R
F
S
I
R
P
L
S
C
S
S
Q
L
R
A
Site 3
S29
S
I
R
P
L
S
C
S
S
Q
L
R
A
A
P
Site 4
S30
I
R
P
L
S
C
S
S
Q
L
R
A
A
P
A
Site 5
T45
V
Q
T
K
T
K
K
T
L
A
K
P
N
I
R
Site 6
S67
V
R
T
P
F
L
L
S
G
T
S
Y
K
D
L
Site 7
S70
P
F
L
L
S
G
T
S
Y
K
D
L
M
P
H
Site 8
Y71
F
L
L
S
G
T
S
Y
K
D
L
M
P
H
D
Site 9
T85
D
L
A
R
A
A
L
T
G
L
L
H
R
T
S
Site 10
T91
L
T
G
L
L
H
R
T
S
V
P
K
E
V
V
Site 11
S92
T
G
L
L
H
R
T
S
V
P
K
E
V
V
D
Site 12
S113
V
I
Q
E
V
K
T
S
N
V
A
R
E
A
A
Site 13
S126
A
A
L
G
A
G
F
S
D
K
T
P
A
H
T
Site 14
T129
G
A
G
F
S
D
K
T
P
A
H
T
V
T
M
Site 15
T133
S
D
K
T
P
A
H
T
V
T
M
A
C
I
S
Site 16
S169
A
G
G
V
E
L
M
S
D
V
P
I
R
H
S
Site 17
S176
S
D
V
P
I
R
H
S
R
K
M
R
K
L
M
Site 18
S191
L
D
L
N
K
A
K
S
M
G
Q
R
L
S
L
Site 19
S197
K
S
M
G
Q
R
L
S
L
I
S
K
F
R
F
Site 20
S215
A
P
E
L
P
A
V
S
E
F
S
T
S
E
T
Site 21
T219
P
A
V
S
E
F
S
T
S
E
T
M
G
H
S
Site 22
S220
A
V
S
E
F
S
T
S
E
T
M
G
H
S
A
Site 23
T222
S
E
F
S
T
S
E
T
M
G
H
S
A
D
R
Site 24
Y244
S
R
L
E
Q
D
E
Y
A
L
R
S
H
S
L
Site 25
S250
E
Y
A
L
R
S
H
S
L
A
K
K
A
Q
D
Site 26
T274
F
K
V
P
G
K
D
T
V
T
K
D
N
G
I
Site 27
T276
V
P
G
K
D
T
V
T
K
D
N
G
I
R
P
Site 28
S284
K
D
N
G
I
R
P
S
S
L
E
Q
M
A
K
Site 29
S285
D
N
G
I
R
P
S
S
L
E
Q
M
A
K
L
Site 30
Y300
K
P
A
F
I
K
P
Y
G
T
V
T
A
A
N
Site 31
T302
A
F
I
K
P
Y
G
T
V
T
A
A
N
S
S
Site 32
T304
I
K
P
Y
G
T
V
T
A
A
N
S
S
F
L
Site 33
S308
G
T
V
T
A
A
N
S
S
F
L
T
D
G
A
Site 34
S309
T
V
T
A
A
N
S
S
F
L
T
D
G
A
S
Site 35
T312
A
A
N
S
S
F
L
T
D
G
A
S
A
M
L
Site 36
S316
S
F
L
T
D
G
A
S
A
M
L
I
M
A
E
Site 37
Y336
M
G
Y
K
P
K
A
Y
L
R
D
F
M
Y
V
Site 38
Y342
A
Y
L
R
D
F
M
Y
V
S
Q
D
P
K
D
Site 39
S344
L
R
D
F
M
Y
V
S
Q
D
P
K
D
Q
L
Site 40
T356
D
Q
L
L
L
G
P
T
Y
A
T
P
K
V
L
Site 41
Y357
Q
L
L
L
G
P
T
Y
A
T
P
K
V
L
E
Site 42
T359
L
L
G
P
T
Y
A
T
P
K
V
L
E
K
A
Site 43
Y402
S
D
W
F
A
E
N
Y
M
G
R
K
T
K
V
Site 44
T407
E
N
Y
M
G
R
K
T
K
V
G
L
P
P
L
Site 45
S423
K
F
N
N
W
G
G
S
L
S
L
G
H
P
F
Site 46
S425
N
N
W
G
G
S
L
S
L
G
H
P
F
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation