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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VCP
Full Name:
Transitional endoplasmic reticulum ATPase
Alias:
15S Mg(2+)-ATPase p97 subunit; IBMPFD; P97; TER ATPase; TERA; Valosin containing protein; Valosin-containing protein
Type:
Chaperone, DNA repair, Endoplasmic reticulum
Mass (Da):
89322
Number AA:
806
UniProt ID:
P55072
International Prot ID:
IPI00022774
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0030433
GO:0006919
GO:0006302
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
G
A
D
S
K
G
D
Site 2
S7
_
M
A
S
G
A
D
S
K
G
D
D
L
S
T
Site 3
S13
D
S
K
G
D
D
L
S
T
A
I
L
K
Q
K
Site 4
T14
S
K
G
D
D
L
S
T
A
I
L
K
Q
K
N
Site 5
S37
E
A
I
N
E
D
N
S
V
V
S
L
S
Q
P
Site 6
S40
N
E
D
N
S
V
V
S
L
S
Q
P
K
M
D
Site 7
S42
D
N
S
V
V
S
L
S
Q
P
K
M
D
E
L
Site 8
T56
L
Q
L
F
R
G
D
T
V
L
L
K
G
K
K
Site 9
S73
E
A
V
C
I
V
L
S
D
D
T
C
S
D
E
Site 10
T76
C
I
V
L
S
D
D
T
C
S
D
E
K
I
R
Site 11
S78
V
L
S
D
D
T
C
S
D
E
K
I
R
M
N
Site 12
S101
V
R
L
G
D
V
I
S
I
Q
P
C
P
D
V
Site 13
Y110
Q
P
C
P
D
V
K
Y
G
K
R
I
H
V
L
Site 14
T122
H
V
L
P
I
D
D
T
V
E
G
I
T
G
N
Site 15
Y138
F
E
V
Y
L
K
P
Y
F
L
E
A
Y
R
P
Site 16
Y143
K
P
Y
F
L
E
A
Y
R
P
I
R
K
G
D
Site 17
T168
V
E
F
K
V
V
E
T
D
P
S
P
Y
C
I
Site 18
Y173
V
E
T
D
P
S
P
Y
C
I
V
A
P
D
T
Site 19
S197
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
Site 20
Y203
E
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
Site 21
Y244
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
Site 22
T249
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
Site 23
S276
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
Site 24
S282
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
Site 25
S284
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
Site 26
T316
I
A
P
K
R
E
K
T
H
G
E
V
E
R
R
Site 27
S326
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
Site 28
T330
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
Site 29
T347
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
Site 30
S352
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
Site 31
T375
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
Site 32
T385
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
Site 33
T436
L
I
D
L
E
D
E
T
I
D
A
E
V
M
N
Site 34
S457
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
Site 35
S459
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
Site 36
T467
N
P
S
A
L
R
E
T
V
V
E
V
P
Q
V
Site 37
Y495
E
L
Q
E
L
V
Q
Y
P
V
E
H
P
D
K
Site 38
T509
K
F
L
K
F
G
M
T
P
S
K
G
V
L
F
Site 39
S511
L
K
F
G
M
T
P
S
K
G
V
L
F
Y
G
Site 40
Y517
P
S
K
G
V
L
F
Y
G
P
P
G
C
G
K
Site 41
T525
G
P
P
G
C
G
K
T
L
L
A
K
A
I
A
Site 42
S541
E
C
Q
A
N
F
I
S
I
K
G
P
E
L
L
Site 43
T549
I
K
G
P
E
L
L
T
M
W
F
G
E
S
E
Site 44
S555
L
T
M
W
F
G
E
S
E
A
N
V
R
E
I
Site 45
S581
L
F
F
D
E
L
D
S
I
A
K
A
R
G
G
Site 46
T606
R
V
I
N
Q
I
L
T
E
M
D
G
M
S
T
Site 47
S612
L
T
E
M
D
G
M
S
T
K
K
N
V
F
I
Site 48
T613
T
E
M
D
G
M
S
T
K
K
N
V
F
I
I
Site 49
T623
N
V
F
I
I
G
A
T
N
R
P
D
I
I
D
Site 50
Y644
G
R
L
D
Q
L
I
Y
I
P
L
P
D
E
K
Site 51
S652
I
P
L
P
D
E
K
S
R
V
A
I
L
K
A
Site 52
S664
L
K
A
N
L
R
K
S
P
V
A
K
D
V
D
Site 53
T679
L
E
F
L
A
K
M
T
N
G
F
S
G
A
D
Site 54
S683
A
K
M
T
N
G
F
S
G
A
D
L
T
E
I
Site 55
T688
G
F
S
G
A
D
L
T
E
I
C
Q
R
A
C
Site 56
S702
C
K
L
A
I
R
E
S
I
E
S
E
I
R
R
Site 57
S705
A
I
R
E
S
I
E
S
E
I
R
R
E
R
E
Site 58
T715
R
R
E
R
E
R
Q
T
N
P
S
A
M
E
V
Site 59
S718
R
E
R
Q
T
N
P
S
A
M
E
V
E
E
D
Site 60
S746
A
M
R
F
A
R
R
S
V
S
D
N
D
I
R
Site 61
S748
R
F
A
R
R
S
V
S
D
N
D
I
R
K
Y
Site 62
Y755
S
D
N
D
I
R
K
Y
E
M
F
A
Q
T
L
Site 63
T761
K
Y
E
M
F
A
Q
T
L
Q
Q
S
R
G
F
Site 64
S765
F
A
Q
T
L
Q
Q
S
R
G
F
G
S
F
R
Site 65
S770
Q
Q
S
R
G
F
G
S
F
R
F
P
S
G
N
Site 66
S775
F
G
S
F
R
F
P
S
G
N
Q
G
G
A
G
Site 67
S784
N
Q
G
G
A
G
P
S
Q
G
S
G
G
G
T
Site 68
S787
G
A
G
P
S
Q
G
S
G
G
G
T
G
G
S
Site 69
T791
S
Q
G
S
G
G
G
T
G
G
S
V
Y
T
E
Site 70
S794
S
G
G
G
T
G
G
S
V
Y
T
E
D
N
D
Site 71
Y796
G
G
T
G
G
S
V
Y
T
E
D
N
D
D
D
Site 72
T797
G
T
G
G
S
V
Y
T
E
D
N
D
D
D
L
Site 73
Y805
E
D
N
D
D
D
L
Y
G
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation