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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A2
Full Name:
Solute carrier family 12 member 2
Alias:
Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; S12A2; Sodium-potassium-chloride transporter 1; Solute carrier family 12 (sodium/potassium/chloride transporters) member 2; Solute carrier family 12, member 2
Type:
Transport protein, facilitator
Mass (Da):
131447
Number AA:
1212
UniProt ID:
P55011
International Prot ID:
IPI00022649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0051739
GO:0030955
GO:0031402
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006814
GO:0070634
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
P
R
P
T
A
P
S
S
G
A
P
Site 2
S9
E
P
R
P
T
A
P
S
S
G
A
P
G
L
A
Site 3
S10
P
R
P
T
A
P
S
S
G
A
P
G
L
A
G
Site 4
S50
P
E
D
A
A
P
A
S
R
D
G
G
G
V
R
Site 5
T75
L
G
R
P
L
G
P
T
P
S
Q
S
R
F
Q
Site 6
S77
R
P
L
G
P
T
P
S
Q
S
R
F
Q
V
D
Site 7
S79
L
G
P
T
P
S
Q
S
R
F
Q
V
D
L
V
Site 8
S87
R
F
Q
V
D
L
V
S
E
N
A
G
R
A
A
Site 9
T116
A
G
A
G
A
K
Q
T
P
A
D
G
E
A
S
Site 10
S123
T
P
A
D
G
E
A
S
G
E
S
E
P
A
K
Site 11
S126
D
G
E
A
S
G
E
S
E
P
A
K
G
S
E
Site 12
S151
V
D
P
A
A
S
S
S
A
E
D
S
L
S
D
Site 13
S155
A
S
S
S
A
E
D
S
L
S
D
A
A
G
V
Site 14
S157
S
S
A
E
D
S
L
S
D
A
A
G
V
G
V
Site 15
S170
G
V
D
G
P
N
V
S
F
Q
N
G
G
D
T
Site 16
T177
S
F
Q
N
G
G
D
T
V
L
S
E
G
S
S
Site 17
S180
N
G
G
D
T
V
L
S
E
G
S
S
L
H
S
Site 18
S183
D
T
V
L
S
E
G
S
S
L
H
S
G
G
G
Site 19
S184
T
V
L
S
E
G
S
S
L
H
S
G
G
G
G
Site 20
S187
S
E
G
S
S
L
H
S
G
G
G
G
G
S
G
Site 21
T203
H
Q
H
Y
Y
Y
D
T
H
T
N
T
Y
Y
L
Site 22
T207
Y
Y
D
T
H
T
N
T
Y
Y
L
R
T
F
G
Site 23
Y208
Y
D
T
H
T
N
T
Y
Y
L
R
T
F
G
H
Site 24
Y209
D
T
H
T
N
T
Y
Y
L
R
T
F
G
H
N
Site 25
T212
T
N
T
Y
Y
L
R
T
F
G
H
N
T
M
D
Site 26
T217
L
R
T
F
G
H
N
T
M
D
A
V
P
R
I
Site 27
Y227
A
V
P
R
I
D
H
Y
R
H
T
A
A
Q
L
Site 28
T230
R
I
D
H
Y
R
H
T
A
A
Q
L
G
E
K
Site 29
S242
G
E
K
L
L
R
P
S
L
A
E
L
H
D
E
Site 30
S265
G
F
A
N
G
E
E
S
T
P
T
R
D
A
V
Site 31
T266
F
A
N
G
E
E
S
T
P
T
R
D
A
V
V
Site 32
T268
N
G
E
E
S
T
P
T
R
D
A
V
V
T
Y
Site 33
T274
P
T
R
D
A
V
V
T
Y
T
A
E
S
K
G
Site 34
Y275
T
R
D
A
V
V
T
Y
T
A
E
S
K
G
V
Site 35
T276
R
D
A
V
V
T
Y
T
A
E
S
K
G
V
V
Site 36
S357
G
G
A
Y
Y
L
I
S
R
S
L
G
P
E
F
Site 37
S359
A
Y
Y
L
I
S
R
S
L
G
P
E
F
G
G
Site 38
S459
G
T
F
I
P
L
E
S
K
K
P
K
G
F
F
Site 39
S516
G
D
L
A
D
P
Q
S
A
I
P
K
G
T
L
Site 40
T549
S
C
V
V
R
D
A
T
G
N
V
N
D
T
I
Site 41
T555
A
T
G
N
V
N
D
T
I
V
T
E
L
T
N
Site 42
S575
C
K
L
N
F
D
F
S
S
C
E
S
S
P
C
Site 43
S576
K
L
N
F
D
F
S
S
C
E
S
S
P
C
S
Site 44
S579
F
D
F
S
S
C
E
S
S
P
C
S
Y
G
L
Site 45
S580
D
F
S
S
C
E
S
S
P
C
S
Y
G
L
M
Site 46
Y584
C
E
S
S
P
C
S
Y
G
L
M
N
N
F
Q
Site 47
S697
N
F
S
V
F
H
A
S
L
A
K
S
P
G
W
Site 48
S701
F
H
A
S
L
A
K
S
P
G
W
R
P
A
F
Site 49
Y751
G
L
Y
I
Y
V
T
Y
K
K
P
D
V
N
W
Site 50
S760
K
P
D
V
N
W
G
S
S
T
Q
A
L
T
Y
Site 51
Y767
S
S
T
Q
A
L
T
Y
L
N
A
L
Q
H
S
Site 52
S774
Y
L
N
A
L
Q
H
S
I
R
L
S
G
V
E
Site 53
S778
L
Q
H
S
I
R
L
S
G
V
E
D
H
V
K
Site 54
T795
R
P
Q
C
L
V
M
T
G
A
P
N
S
R
P
Site 55
Y842
M
S
I
D
Q
A
K
Y
Q
R
W
L
I
K
N
Site 56
Y869
D
L
R
E
G
A
Q
Y
L
M
Q
A
A
G
L
Site 57
T883
L
G
R
M
K
P
N
T
L
V
L
G
F
K
K
Site 58
Y903
D
M
R
D
V
D
M
Y
I
N
L
F
H
D
A
Site 59
S929
L
K
E
G
L
D
I
S
H
L
Q
G
Q
E
E
Site 60
S939
Q
G
Q
E
E
L
L
S
S
Q
E
K
S
P
G
Site 61
S940
G
Q
E
E
L
L
S
S
Q
E
K
S
P
G
T
Site 62
S944
L
L
S
S
Q
E
K
S
P
G
T
K
D
V
V
Site 63
S953
G
T
K
D
V
V
V
S
V
E
Y
S
K
K
S
Site 64
Y956
D
V
V
V
S
V
E
Y
S
K
K
S
D
L
D
Site 65
S957
V
V
V
S
V
E
Y
S
K
K
S
D
L
D
T
Site 66
S960
S
V
E
Y
S
K
K
S
D
L
D
T
S
K
P
Site 67
T964
S
K
K
S
D
L
D
T
S
K
P
L
S
E
K
Site 68
S965
K
K
S
D
L
D
T
S
K
P
L
S
E
K
P
Site 69
S969
L
D
T
S
K
P
L
S
E
K
P
I
T
H
K
Site 70
T974
P
L
S
E
K
P
I
T
H
K
V
E
E
E
D
Site 71
T984
V
E
E
E
D
G
K
T
A
T
Q
P
L
L
K
Site 72
S994
Q
P
L
L
K
K
E
S
K
G
P
I
V
P
L
Site 73
S1012
D
Q
K
L
L
E
A
S
T
Q
F
Q
K
K
Q
Site 74
T1074
H
D
R
R
A
M
A
T
L
L
S
K
F
R
I
Site 75
T1094
M
V
L
G
D
I
N
T
K
P
K
K
E
N
I
Site 76
T1135
E
D
E
P
W
R
I
T
D
N
E
L
E
L
Y
Site 77
Y1142
T
D
N
E
L
E
L
Y
K
T
K
T
Y
R
Q
Site 78
T1144
N
E
L
E
L
Y
K
T
K
T
Y
R
Q
I
R
Site 79
T1146
L
E
L
Y
K
T
K
T
Y
R
Q
I
R
L
N
Site 80
S1206
L
V
R
G
N
H
Q
S
V
L
T
F
Y
S
_
Site 81
Y1211
H
Q
S
V
L
T
F
Y
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation