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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADPRH
Full Name:
[Protein ADP-ribosylarginine] hydrolase
Alias:
ADP- ribosylarginine hydrolase; ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylarginine hydrolase; ARH1; EC 3.2.2.19
Type:
Enzyme - Hydrolase
Mass (Da):
39507
Number AA:
357
UniProt ID:
P54922
International Prot ID:
IPI00009258
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003875
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0051725
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
E
K
Y
V
A
A
M
V
L
S
Site 2
Y19
A
A
G
D
A
L
G
Y
Y
N
G
K
W
E
F
Site 3
Y20
A
G
D
A
L
G
Y
Y
N
G
K
W
E
F
L
Site 4
S54
D
V
G
R
W
R
V
S
D
D
T
V
M
H
L
Site 5
T57
R
W
R
V
S
D
D
T
V
M
H
L
A
T
A
Site 6
Y80
A
P
K
L
T
Q
L
Y
Y
L
L
A
K
H
Y
Site 7
Y81
P
K
L
T
Q
L
Y
Y
L
L
A
K
H
Y
Q
Site 8
S103
G
R
A
P
G
G
A
S
V
H
N
A
M
Q
L
Site 9
S146
G
L
R
F
P
H
H
S
Q
L
D
T
L
I
Q
Site 10
T150
P
H
H
S
Q
L
D
T
L
I
Q
V
S
I
E
Site 11
T162
S
I
E
S
G
R
M
T
H
H
H
P
T
G
Y
Site 12
Y205
L
L
P
E
A
K
K
Y
I
V
Q
S
G
Y
F
Site 13
Y211
K
Y
I
V
Q
S
G
Y
F
V
E
E
N
L
Q
Site 14
Y230
F
Q
T
K
W
E
N
Y
L
K
L
R
G
I
L
Site 15
S241
R
G
I
L
D
G
E
S
A
P
T
F
P
E
S
Site 16
T244
L
D
G
E
S
A
P
T
F
P
E
S
F
G
V
Site 17
S248
S
A
P
T
F
P
E
S
F
G
V
K
E
R
D
Site 18
Y258
V
K
E
R
D
Q
F
Y
T
S
L
S
Y
S
G
Site 19
T259
K
E
R
D
Q
F
Y
T
S
L
S
Y
S
G
W
Site 20
S260
E
R
D
Q
F
Y
T
S
L
S
Y
S
G
W
G
Site 21
S262
D
Q
F
Y
T
S
L
S
Y
S
G
W
G
G
S
Site 22
S264
F
Y
T
S
L
S
Y
S
G
W
G
G
S
S
G
Site 23
S270
Y
S
G
W
G
G
S
S
G
H
D
A
P
M
I
Site 24
S288
A
V
L
A
A
G
D
S
W
K
E
L
A
H
R
Site 25
S305
F
H
G
G
D
S
D
S
T
A
A
I
A
G
C
Site 26
T306
H
G
G
D
S
D
S
T
A
A
I
A
G
C
W
Site 27
S324
M
Y
G
F
K
G
V
S
P
S
N
Y
E
K
L
Site 28
S326
G
F
K
G
V
S
P
S
N
Y
E
K
L
E
Y
Site 29
Y328
K
G
V
S
P
S
N
Y
E
K
L
E
Y
R
N
Site 30
Y333
S
N
Y
E
K
L
E
Y
R
N
R
L
E
E
T
Site 31
Y345
E
E
T
A
R
A
L
Y
S
L
G
S
K
E
D
Site 32
S346
E
T
A
R
A
L
Y
S
L
G
S
K
E
D
T
Site 33
S349
R
A
L
Y
S
L
G
S
K
E
D
T
V
I
S
Site 34
T353
S
L
G
S
K
E
D
T
V
I
S
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation