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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH18A1
Full Name:
Delta-1-pyrroline-5-carboxylate synthase
Alias:
Aldehyde dehydrogenase 18 family member A1; Aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1; Delta 1-pyrroline-5-carboxylate synthetase; EC 1.2.1.41; EC 2.7.2.11; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GK; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GPR; GSAS; P5CS; PYCS
Type:
EC 2.7.2.11; Oxidoreductase; Kinase (non-protein); Amino Acid Metabolism - arginine and proline; EC 1.2.1.41; Mitochondrial
Mass (Da):
87302
Number AA:
795
UniProt ID:
P54886
International Prot ID:
IPI00008982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005743
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004349
GO:0004350
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006561
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
R
S
H
C
I
Q
P
S
V
I
R
H
V
R
S
Site 2
T50
W
S
N
I
P
F
I
T
V
P
L
S
R
T
H
Site 3
S54
P
F
I
T
V
P
L
S
R
T
H
G
K
S
F
Site 4
T56
I
T
V
P
L
S
R
T
H
G
K
S
F
A
H
Site 5
S60
L
S
R
T
H
G
K
S
F
A
H
R
S
E
L
Site 6
S65
G
K
S
F
A
H
R
S
E
L
K
H
A
K
R
Site 7
S103
A
S
I
V
E
Q
V
S
V
L
Q
N
Q
G
R
Site 8
S134
L
R
H
E
I
L
L
S
Q
S
V
R
Q
A
L
Site 9
S136
H
E
I
L
L
S
Q
S
V
R
Q
A
L
H
S
Site 10
S143
S
V
R
Q
A
L
H
S
G
Q
N
Q
L
K
E
Site 11
T206
K
R
R
N
L
N
G
T
L
H
E
L
L
R
M
Site 12
S233
V
P
P
A
E
P
N
S
D
L
Q
G
V
N
V
Site 13
S242
L
Q
G
V
N
V
I
S
V
K
D
N
D
S
L
Site 14
S248
I
S
V
K
D
N
D
S
L
A
A
R
L
A
V
Site 15
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Site 16
S278
L
F
D
S
P
P
G
S
D
D
A
K
L
I
D
Site 17
Y288
A
K
L
I
D
I
F
Y
P
G
D
Q
Q
S
V
Site 18
S294
F
Y
P
G
D
Q
Q
S
V
T
F
G
T
K
S
Site 19
T296
P
G
D
Q
Q
S
V
T
F
G
T
K
S
R
V
Site 20
S301
S
V
T
F
G
T
K
S
R
V
G
M
G
G
M
Site 21
T331
S
V
V
I
A
N
G
T
H
P
K
V
S
G
H
Site 22
T351
V
E
G
K
K
V
G
T
F
F
S
E
V
K
P
Site 23
S354
K
K
V
G
T
F
F
S
E
V
K
P
A
G
P
Site 24
T362
E
V
K
P
A
G
P
T
V
E
Q
Q
G
E
M
Site 25
S372
Q
Q
G
E
M
A
R
S
G
G
R
M
L
A
T
Site 26
T379
S
G
G
R
M
L
A
T
L
E
P
E
Q
R
A
Site 27
T397
H
H
L
A
D
L
L
T
D
Q
R
D
E
I
L
Site 28
S427
A
P
L
L
K
R
L
S
L
S
T
S
K
L
N
Site 29
S429
L
L
K
R
L
S
L
S
T
S
K
L
N
S
L
Site 30
T430
L
K
R
L
S
L
S
T
S
K
L
N
S
L
A
Site 31
S431
K
R
L
S
L
S
T
S
K
L
N
S
L
A
I
Site 32
S435
L
S
T
S
K
L
N
S
L
A
I
G
L
R
Q
Site 33
S446
G
L
R
Q
I
A
A
S
S
Q
D
S
V
G
R
Site 34
S447
L
R
Q
I
A
A
S
S
Q
D
S
V
G
R
V
Site 35
S450
I
A
A
S
S
Q
D
S
V
G
R
V
L
R
R
Site 36
T458
V
G
R
V
L
R
R
T
R
I
A
K
N
L
E
Site 37
S512
G
G
K
E
A
A
H
S
N
R
I
L
H
L
L
Site 38
Y587
S
E
G
I
C
H
M
Y
V
D
S
E
A
S
V
Site 39
S604
V
T
R
L
V
R
D
S
K
C
E
Y
P
A
A
Site 40
Y608
V
R
D
S
K
C
E
Y
P
A
A
C
N
A
L
Site 41
S652
H
A
G
P
K
F
A
S
Y
L
T
F
S
P
S
Site 42
Y653
A
G
P
K
F
A
S
Y
L
T
F
S
P
S
E
Site 43
T655
P
K
F
A
S
Y
L
T
F
S
P
S
E
V
K
Site 44
S659
S
Y
L
T
F
S
P
S
E
V
K
S
L
R
T
Site 45
S663
F
S
P
S
E
V
K
S
L
R
T
E
Y
G
D
Site 46
Y668
V
K
S
L
R
T
E
Y
G
D
L
E
L
C
I
Site 47
Y691
A
I
D
H
I
H
K
Y
G
S
S
H
T
D
V
Site 48
T706
I
V
T
E
D
E
N
T
A
E
F
F
L
Q
H
Site 49
S728
W
N
A
S
T
R
F
S
D
G
Y
R
F
G
L
Site 50
Y731
S
T
R
F
S
D
G
Y
R
F
G
L
G
A
E
Site 51
S742
L
G
A
E
V
G
I
S
T
S
R
I
H
A
R
Site 52
T760
G
L
E
G
L
L
T
T
K
W
L
L
R
G
K
Site 53
S772
R
G
K
D
H
V
V
S
D
F
S
E
H
G
S
Site 54
S775
D
H
V
V
S
D
F
S
E
H
G
S
L
K
Y
Site 55
S779
S
D
F
S
E
H
G
S
L
K
Y
L
H
E
N
Site 56
Y782
S
E
H
G
S
L
K
Y
L
H
E
N
L
P
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation