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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMGCS2
Full Name:
Hydroxymethylglutaryl-CoA synthase, mitochondrial
Alias:
3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMCS2; HMG-CoA synthase; Hydroxymethylglutaryl-CoA synthase, mitochondrial
Type:
Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 2.3.3.10; Transferase; Carbohydrate Metabolism - butanoate; Mitochondrial
Mass (Da):
56635
Number AA:
508
UniProt ID:
P54868
International Prot ID:
IPI00008934
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004421
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0008299
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
Q
R
L
L
T
P
V
K
R
I
L
Q
Site 2
T15
V
K
R
I
L
Q
L
T
R
A
V
Q
E
T
S
Site 3
S22
T
R
A
V
Q
E
T
S
L
T
P
A
R
L
L
Site 4
S40
H
Q
R
F
S
T
A
S
A
V
P
L
A
K
T
Site 5
T49
V
P
L
A
K
T
D
T
W
P
K
D
V
G
I
Site 6
Y67
E
V
Y
F
P
A
Q
Y
V
D
Q
T
D
L
E
Site 7
T71
P
A
Q
Y
V
D
Q
T
D
L
E
K
Y
N
N
Site 8
Y76
D
Q
T
D
L
E
K
Y
N
N
V
E
A
G
K
Site 9
Y84
N
N
V
E
A
G
K
Y
T
V
G
L
G
Q
T
Site 10
S97
Q
T
R
M
G
F
C
S
V
Q
E
D
I
N
S
Site 11
S123
R
I
Q
L
P
W
D
S
V
G
R
L
E
V
G
Site 12
T131
V
G
R
L
E
V
G
T
E
T
I
I
D
K
S
Site 13
T143
D
K
S
K
A
V
K
T
V
L
M
E
L
F
Q
Site 14
T162
T
D
I
E
G
I
D
T
T
N
A
C
Y
G
G
Site 15
Y189
S
S
S
W
D
G
R
Y
A
M
V
V
C
G
D
Site 16
T208
P
S
G
N
A
R
P
T
G
G
A
G
A
V
A
Site 17
T233
L
E
R
G
L
R
G
T
H
M
E
N
V
Y
D
Site 18
Y239
G
T
H
M
E
N
V
Y
D
F
Y
K
P
N
L
Site 19
Y242
M
E
N
V
Y
D
F
Y
K
P
N
L
A
S
E
Site 20
S248
F
Y
K
P
N
L
A
S
E
Y
P
I
V
D
G
Site 21
Y250
K
P
N
L
A
S
E
Y
P
I
V
D
G
K
L
Site 22
Y262
G
K
L
S
I
Q
C
Y
L
R
A
L
D
R
C
Site 23
Y270
L
R
A
L
D
R
C
Y
T
S
Y
R
K
K
I
Site 24
T271
R
A
L
D
R
C
Y
T
S
Y
R
K
K
I
Q
Site 25
Y273
L
D
R
C
Y
T
S
Y
R
K
K
I
Q
N
Q
Site 26
S286
N
Q
W
K
Q
A
G
S
D
R
P
F
T
L
D
Site 27
T291
A
G
S
D
R
P
F
T
L
D
D
L
Q
Y
M
Site 28
S322
L
M
F
N
D
F
L
S
A
S
S
D
T
Q
T
Site 29
S325
N
D
F
L
S
A
S
S
D
T
Q
T
S
L
Y
Site 30
T329
S
A
S
S
D
T
Q
T
S
L
Y
K
G
L
E
Site 31
S330
A
S
S
D
T
Q
T
S
L
Y
K
G
L
E
A
Site 32
Y332
S
D
T
Q
T
S
L
Y
K
G
L
E
A
F
G
Site 33
T346
G
G
L
K
L
E
D
T
Y
T
N
K
D
L
D
Site 34
Y347
G
L
K
L
E
D
T
Y
T
N
K
D
L
D
K
Site 35
T348
L
K
L
E
D
T
Y
T
N
K
D
L
D
K
A
Site 36
S360
D
K
A
L
L
K
A
S
Q
D
M
F
D
K
K
Site 37
T368
Q
D
M
F
D
K
K
T
K
A
S
L
Y
L
S
Site 38
S371
F
D
K
K
T
K
A
S
L
Y
L
S
T
H
N
Site 39
Y373
K
K
T
K
A
S
L
Y
L
S
T
H
N
G
N
Site 40
S375
T
K
A
S
L
Y
L
S
T
H
N
G
N
M
Y
Site 41
Y382
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
Site 42
S385
N
G
N
M
Y
T
S
S
L
Y
G
C
L
A
S
Site 43
S398
A
S
L
L
S
H
H
S
A
Q
E
L
A
G
S
Site 44
S405
S
A
Q
E
L
A
G
S
R
I
G
A
F
S
Y
Site 45
S426
S
F
F
S
F
R
V
S
Q
D
A
A
P
G
S
Site 46
S433
S
Q
D
A
A
P
G
S
P
L
D
K
L
V
S
Site 47
S440
S
P
L
D
K
L
V
S
S
T
S
D
L
P
K
Site 48
S441
P
L
D
K
L
V
S
S
T
S
D
L
P
K
R
Site 49
S443
D
K
L
V
S
S
T
S
D
L
P
K
R
L
A
Site 50
S451
D
L
P
K
R
L
A
S
R
K
C
V
S
P
E
Site 51
S456
L
A
S
R
K
C
V
S
P
E
E
F
T
E
I
Site 52
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
N
S
Site 53
T482
N
F
S
P
P
G
D
T
N
S
L
F
P
G
T
Site 54
S484
S
P
P
G
D
T
N
S
L
F
P
G
T
W
Y
Site 55
Y491
S
L
F
P
G
T
W
Y
L
E
R
V
D
E
Q
Site 56
Y503
D
E
Q
H
R
R
K
Y
A
R
R
P
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation