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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA2
Full Name:
Heat shock-related 70 kDa protein 2
Alias:
Heat shock 70 kDa protein 2; Heat shock 70kDa protein 2; Heat-shock 70kD protein-2; HSP72
Type:
Chaperone protein
Mass (Da):
70021
Number AA:
639
UniProt ID:
P54652
International Prot ID:
IPI00007702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0007140
GO:0006986
GO:0007286
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock-related 70 kDa protein 2 pan-specific antibody AB-NN060-12#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN060-12
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Site 2
T39
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
Site 3
S41
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
Site 4
Y42
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
E
Site 5
T48
S
Y
V
A
F
T
D
T
E
R
L
I
G
D
A
Site 6
T83
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
Site 7
S97
H
W
P
F
R
V
V
S
E
G
G
K
P
K
V
Site 8
Y108
K
P
K
V
Q
V
E
Y
K
G
E
T
K
T
F
Site 9
T112
Q
V
E
Y
K
G
E
T
K
T
F
F
P
E
E
Site 10
T114
E
Y
K
G
E
T
K
T
F
F
P
E
E
I
S
Site 11
S121
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
Site 12
S122
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
Site 13
T126
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
Site 14
Y135
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
Site 15
Y150
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
Site 16
S154
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
Site 17
T159
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
Site 18
T164
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
Site 19
T166
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
Site 20
T178
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
Site 21
S224
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
Site 22
S242
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
Site 23
T268
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
Site 24
T276
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
Site 25
S278
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
Site 26
S280
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
Site 27
S284
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
Site 28
S289
Q
A
S
I
E
I
D
S
L
Y
E
G
V
D
F
Site 29
Y291
S
I
E
I
D
S
L
Y
E
G
V
D
F
Y
T
Site 30
Y297
L
Y
E
G
V
D
F
Y
T
S
I
T
R
A
R
Site 31
S299
E
G
V
D
F
Y
T
S
I
T
R
A
R
F
E
Site 32
T301
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
Site 33
T316
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
Site 34
S365
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
Site 35
T414
E
T
A
G
G
V
M
T
P
L
I
K
R
N
T
Site 36
T421
T
P
L
I
K
R
N
T
T
I
P
T
K
Q
T
Site 37
T422
P
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
Site 38
T430
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Site 39
S435
T
Q
T
F
T
T
Y
S
D
N
Q
S
S
V
L
Site 40
S439
T
T
Y
S
D
N
Q
S
S
V
L
V
Q
V
Y
Site 41
T453
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
Site 42
T465
L
L
G
K
F
D
L
T
G
I
P
P
A
P
R
Site 43
T480
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
Site 44
S497
N
V
T
A
A
D
K
S
T
G
K
E
N
K
I
Site 45
T505
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
Site 46
S514
T
N
D
K
G
R
L
S
K
D
D
I
D
R
M
Site 47
Y528
M
V
Q
E
A
E
R
Y
K
S
E
D
E
A
N
Site 48
S530
Q
E
A
E
R
Y
K
S
E
D
E
A
N
R
D
Site 49
Y550
N
A
L
E
S
Y
T
Y
N
I
K
Q
T
V
E
Site 50
T555
Y
T
Y
N
I
K
Q
T
V
E
D
E
K
L
R
Site 51
S566
E
K
L
R
G
K
I
S
E
Q
D
K
N
K
I
Site 52
Y595
Q
M
A
E
K
D
E
Y
E
H
K
Q
K
E
L
Site 53
S611
R
V
C
N
P
I
I
S
K
L
Y
Q
G
G
P
Site 54
Y614
N
P
I
I
S
K
L
Y
Q
G
G
P
G
G
G
Site 55
S622
Q
G
G
P
G
G
G
S
G
G
G
G
S
G
A
Site 56
S627
G
G
S
G
G
G
G
S
G
A
S
G
G
P
T
Site 57
S630
G
G
G
G
S
G
A
S
G
G
P
T
I
E
E
Site 58
T634
S
G
A
S
G
G
P
T
I
E
E
V
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation