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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PMS2
Full Name:
Mismatch repair endonuclease PMS2
Alias:
DNA mismatch repair gene; DNA mismatch repair protein PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; PMS1 protein homologue 2; PMS2 postmeiotic segregation increased 2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2
Type:
DNA repair; EC 3.1.-.-; Cell cycle regulation; Hydrolase
Mass (Da):
95798
Number AA:
862
UniProt ID:
P54278
International Prot ID:
IPI00746337
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004519
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006298
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
R
A
E
S
S
S
T
E
P
A
K
Site 2
S8
M
E
R
A
E
S
S
S
T
E
P
A
K
A
I
Site 3
T9
E
R
A
E
S
S
S
T
E
P
A
K
A
I
K
Site 4
S22
I
K
P
I
D
R
K
S
V
H
Q
I
C
S
G
Site 5
T84
E
E
N
F
E
G
L
T
L
K
H
H
T
S
K
Site 6
S90
L
T
L
K
H
H
T
S
K
I
Q
E
F
A
D
Site 7
T103
A
D
L
T
Q
V
E
T
F
G
F
R
G
E
A
Site 8
T147
N
G
K
I
I
Q
K
T
P
Y
P
R
P
R
G
Site 9
Y149
K
I
I
Q
K
T
P
Y
P
R
P
R
G
T
T
Site 10
T155
P
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
Site 11
T156
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
F
Site 12
S158
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
Site 13
T165
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
Site 14
Y181
Q
R
N
I
K
K
E
Y
A
K
M
V
Q
V
L
Site 15
T203
A
G
I
R
V
S
C
T
N
Q
L
G
Q
G
K
Site 16
S222
V
C
T
G
G
S
P
S
I
K
E
N
I
G
S
Site 17
S229
S
I
K
E
N
I
G
S
V
F
G
Q
K
Q
L
Site 18
S248
P
F
V
Q
L
P
P
S
D
S
V
C
E
E
Y
Site 19
S250
V
Q
L
P
P
S
D
S
V
C
E
E
Y
G
L
Site 20
S258
V
C
E
E
Y
G
L
S
C
S
D
A
L
H
N
Site 21
S260
E
E
Y
G
L
S
C
S
D
A
L
H
N
L
F
Site 22
T277
S
G
F
I
S
Q
C
T
H
G
V
G
R
S
S
Site 23
S284
T
H
G
V
G
R
S
S
T
D
R
Q
F
F
F
Site 24
T285
H
G
V
G
R
S
S
T
D
R
Q
F
F
F
I
Site 25
Y310
C
R
L
V
N
E
V
Y
H
M
Y
N
R
H
Q
Site 26
T337
E
C
V
D
I
N
V
T
P
D
K
R
Q
I
L
Site 27
S373
D
V
N
K
L
N
V
S
Q
Q
P
L
L
D
V
Site 28
S403
M
V
E
K
Q
D
Q
S
P
S
L
R
T
G
E
Site 29
S405
E
K
Q
D
Q
S
P
S
L
R
T
G
E
E
K
Site 30
S416
G
E
E
K
K
D
V
S
I
S
R
L
R
E
A
Site 31
S418
E
K
K
D
V
S
I
S
R
L
R
E
A
F
S
Site 32
S425
S
R
L
R
E
A
F
S
L
R
H
T
T
E
N
Site 33
T429
E
A
F
S
L
R
H
T
T
E
N
K
P
H
S
Site 34
T430
A
F
S
L
R
H
T
T
E
N
K
P
H
S
P
Site 35
S436
T
T
E
N
K
P
H
S
P
K
T
P
E
P
R
Site 36
T439
N
K
P
H
S
P
K
T
P
E
P
R
R
S
P
Site 37
S445
K
T
P
E
P
R
R
S
P
L
G
Q
K
R
G
Site 38
S455
G
Q
K
R
G
M
L
S
S
S
T
S
G
A
I
Site 39
S456
Q
K
R
G
M
L
S
S
S
T
S
G
A
I
S
Site 40
S457
K
R
G
M
L
S
S
S
T
S
G
A
I
S
D
Site 41
S459
G
M
L
S
S
S
T
S
G
A
I
S
D
K
G
Site 42
S463
S
S
T
S
G
A
I
S
D
K
G
V
L
R
P
Site 43
S476
R
P
Q
K
E
A
V
S
S
S
H
G
P
S
D
Site 44
S477
P
Q
K
E
A
V
S
S
S
H
G
P
S
D
P
Site 45
S478
Q
K
E
A
V
S
S
S
H
G
P
S
D
P
T
Site 46
S482
V
S
S
S
H
G
P
S
D
P
T
D
R
A
E
Site 47
T485
S
H
G
P
S
D
P
T
D
R
A
E
V
E
K
Site 48
S494
R
A
E
V
E
K
D
S
G
H
G
S
T
S
V
Site 49
S498
E
K
D
S
G
H
G
S
T
S
V
D
S
E
G
Site 50
S500
D
S
G
H
G
S
T
S
V
D
S
E
G
F
S
Site 51
S503
H
G
S
T
S
V
D
S
E
G
F
S
I
P
D
Site 52
S507
S
V
D
S
E
G
F
S
I
P
D
T
G
S
H
Site 53
T511
E
G
F
S
I
P
D
T
G
S
H
C
S
S
E
Site 54
S513
F
S
I
P
D
T
G
S
H
C
S
S
E
Y
A
Site 55
S517
D
T
G
S
H
C
S
S
E
Y
A
A
S
S
P
Site 56
Y519
G
S
H
C
S
S
E
Y
A
A
S
S
P
G
D
Site 57
S523
S
S
E
Y
A
A
S
S
P
G
D
R
G
S
Q
Site 58
S529
S
S
P
G
D
R
G
S
Q
E
H
V
D
S
Q
Site 59
S535
G
S
Q
E
H
V
D
S
Q
E
K
A
P
E
T
Site 60
T542
S
Q
E
K
A
P
E
T
D
D
S
F
S
D
V
Site 61
S545
K
A
P
E
T
D
D
S
F
S
D
V
D
C
H
Site 62
S547
P
E
T
D
D
S
F
S
D
V
D
C
H
S
N
Site 63
T558
C
H
S
N
Q
E
D
T
G
C
K
F
R
V
L
Site 64
T573
P
Q
P
T
N
L
A
T
P
N
T
K
R
F
K
Site 65
T576
T
N
L
A
T
P
N
T
K
R
F
K
K
E
E
Site 66
S586
F
K
K
E
E
I
L
S
S
S
D
I
C
Q
K
Site 67
S588
K
E
E
I
L
S
S
S
D
I
C
Q
K
L
V
Site 68
T597
I
C
Q
K
L
V
N
T
Q
D
M
S
A
S
Q
Site 69
S601
L
V
N
T
Q
D
M
S
A
S
Q
V
D
V
A
Site 70
S603
N
T
Q
D
M
S
A
S
Q
V
D
V
A
V
K
Site 71
S621
K
V
V
P
L
D
F
S
M
S
S
L
A
K
R
Site 72
S624
P
L
D
F
S
M
S
S
L
A
K
R
I
K
Q
Site 73
S639
L
H
H
E
A
Q
Q
S
E
G
E
Q
N
Y
R
Site 74
S669
D
E
L
R
K
E
I
S
K
T
M
F
A
E
M
Site 75
T671
L
R
K
E
I
S
K
T
M
F
A
E
M
E
I
Site 76
Y707
Q
H
A
T
D
E
K
Y
N
F
E
M
L
Q
Q
Site 77
T762
I
D
E
N
A
P
V
T
E
R
A
K
L
I
S
Site 78
S769
T
E
R
A
K
L
I
S
L
P
T
S
K
N
W
Site 79
S773
K
L
I
S
L
P
T
S
K
N
W
T
F
G
P
Site 80
T777
L
P
T
S
K
N
W
T
F
G
P
Q
D
V
D
Site 81
S815
A
S
R
A
C
R
K
S
V
M
I
G
T
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation