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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PMS1
Full Name:
PMS1 protein homolog 1
Alias:
DNA mismatch repair protein PMS1; PMS1 postmeiotic segregation increased 1; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMSL1
Type:
DNA repair
Mass (Da):
105830
Number AA:
932
UniProt ID:
P54277
International Prot ID:
IPI00005541
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030983
PhosphoSite+
KinaseNET
Biological Process:
GO:0006298
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
K
Q
L
P
A
A
T
V
R
L
L
S
S
S
Site 2
S13
A
A
T
V
R
L
L
S
S
S
Q
I
I
T
S
Site 3
S14
A
T
V
R
L
L
S
S
S
Q
I
I
T
S
V
Site 4
S39
S
L
D
A
G
A
T
S
V
D
V
K
L
E
N
Site 5
Y73
A
P
V
M
A
M
K
Y
Y
T
S
K
I
N
S
Site 6
Y74
P
V
M
A
M
K
Y
Y
T
S
K
I
N
S
H
Site 7
S80
Y
Y
T
S
K
I
N
S
H
E
D
L
E
N
L
Site 8
T89
E
D
L
E
N
L
T
T
Y
G
F
R
G
E
A
Site 9
Y90
D
L
E
N
L
T
T
Y
G
F
R
G
E
A
L
Site 10
Y121
A
D
N
F
S
T
Q
Y
V
L
D
G
S
G
H
Site 11
S131
D
G
S
G
H
I
L
S
Q
K
P
S
H
L
G
Site 12
S135
H
I
L
S
Q
K
P
S
H
L
G
Q
G
T
T
Site 13
S160
P
V
R
K
Q
F
Y
S
T
A
K
K
C
K
D
Site 14
Y227
N
N
M
E
S
F
Q
Y
H
S
E
E
S
Q
I
Site 15
S232
F
Q
Y
H
S
E
E
S
Q
I
Y
L
S
G
F
Site 16
Y235
H
S
E
E
S
Q
I
Y
L
S
G
F
L
P
K
Site 17
S237
E
E
S
Q
I
Y
L
S
G
F
L
P
K
C
D
Site 18
S248
P
K
C
D
A
D
H
S
F
T
S
L
S
T
P
Site 19
S251
D
A
D
H
S
F
T
S
L
S
T
P
E
R
S
Site 20
S253
D
H
S
F
T
S
L
S
T
P
E
R
S
F
I
Site 21
T254
H
S
F
T
S
L
S
T
P
E
R
S
F
I
F
Site 22
S258
S
L
S
T
P
E
R
S
F
I
F
I
N
S
R
Site 23
Y280
L
K
L
I
R
H
H
Y
N
L
K
C
L
K
E
Site 24
S288
N
L
K
C
L
K
E
S
T
R
L
Y
P
V
F
Site 25
T311
A
D
V
D
V
N
L
T
P
D
K
S
Q
V
L
Site 26
S315
V
N
L
T
P
D
K
S
Q
V
L
L
Q
N
K
Site 27
Y337
E
N
L
M
T
T
C
Y
G
P
L
P
S
T
N
Site 28
S342
T
C
Y
G
P
L
P
S
T
N
S
Y
E
N
N
Site 29
T343
C
Y
G
P
L
P
S
T
N
S
Y
E
N
N
K
Site 30
S345
G
P
L
P
S
T
N
S
Y
E
N
N
K
T
D
Site 31
Y346
P
L
P
S
T
N
S
Y
E
N
N
K
T
D
V
Site 32
T351
N
S
Y
E
N
N
K
T
D
V
S
A
A
D
I
Site 33
S376
L
F
N
K
V
E
S
S
G
K
N
Y
S
N
V
Site 34
Y380
V
E
S
S
G
K
N
Y
S
N
V
D
T
S
V
Site 35
S381
E
S
S
G
K
N
Y
S
N
V
D
T
S
V
I
Site 36
T385
K
N
Y
S
N
V
D
T
S
V
I
P
F
Q
N
Site 37
T403
N
D
E
S
G
K
N
T
D
D
C
L
N
H
Q
Site 38
S423
F
G
Y
G
H
C
S
S
E
I
S
N
I
D
K
Site 39
S426
G
H
C
S
S
E
I
S
N
I
D
K
N
T
K
Site 40
S442
A
F
Q
D
I
S
M
S
N
V
S
W
E
N
S
Site 41
S445
D
I
S
M
S
N
V
S
W
E
N
S
Q
T
E
Site 42
S449
S
N
V
S
W
E
N
S
Q
T
E
Y
S
K
T
Site 43
S454
E
N
S
Q
T
E
Y
S
K
T
C
F
I
S
S
Site 44
T456
S
Q
T
E
Y
S
K
T
C
F
I
S
S
V
K
Site 45
S461
S
K
T
C
F
I
S
S
V
K
H
T
Q
S
E
Site 46
T465
F
I
S
S
V
K
H
T
Q
S
E
N
G
N
K
Site 47
S467
S
S
V
K
H
T
Q
S
E
N
G
N
K
D
H
Site 48
S478
N
K
D
H
I
D
E
S
G
E
N
E
E
E
A
Site 49
S494
L
E
N
S
S
E
I
S
A
D
E
W
S
R
G
Site 50
S507
R
G
N
I
L
K
N
S
V
G
E
N
I
E
P
Site 51
S523
K
I
L
V
P
E
K
S
L
P
C
K
V
S
N
Site 52
S529
K
S
L
P
C
K
V
S
N
N
N
Y
P
I
P
Site 53
Y533
C
K
V
S
N
N
N
Y
P
I
P
E
Q
M
N
Site 54
S557
S
N
V
I
D
N
K
S
G
K
V
T
A
Y
D
Site 55
T561
D
N
K
S
G
K
V
T
A
Y
D
L
L
S
N
Site 56
Y563
K
S
G
K
V
T
A
Y
D
L
L
S
N
R
V
Site 57
S567
V
T
A
Y
D
L
L
S
N
R
V
I
K
K
P
Site 58
T596
F
L
I
E
N
P
K
T
S
L
E
D
A
T
L
Site 59
T602
K
T
S
L
E
D
A
T
L
Q
I
E
E
L
W
Site 60
T611
Q
I
E
E
L
W
K
T
L
S
E
E
E
K
L
Site 61
S613
E
E
L
W
K
T
L
S
E
E
E
K
L
K
Y
Site 62
Y620
S
E
E
E
K
L
K
Y
E
E
K
A
T
K
D
Site 63
T625
L
K
Y
E
E
K
A
T
K
D
L
E
R
Y
N
Site 64
S633
K
D
L
E
R
Y
N
S
Q
M
K
R
A
I
E
Site 65
S643
K
R
A
I
E
Q
E
S
Q
M
S
L
K
D
G
Site 66
S646
I
E
Q
E
S
Q
M
S
L
K
D
G
R
K
K
Site 67
S658
R
K
K
I
K
P
T
S
A
W
N
L
A
Q
K
Site 68
S671
Q
K
H
K
L
K
T
S
L
S
N
Q
P
K
L
Site 69
S673
H
K
L
K
T
S
L
S
N
Q
P
K
L
D
E
Site 70
S684
K
L
D
E
L
L
Q
S
Q
I
E
K
R
R
S
Site 71
S691
S
Q
I
E
K
R
R
S
Q
N
I
K
M
V
Q
Site 72
T779
L
E
K
P
I
M
L
T
E
S
L
F
N
G
S
Site 73
S781
K
P
I
M
L
T
E
S
L
F
N
G
S
H
Y
Site 74
Y788
S
L
F
N
G
S
H
Y
L
D
V
L
Y
K
M
Site 75
Y793
S
H
Y
L
D
V
L
Y
K
M
T
A
D
D
Q
Site 76
Y802
M
T
A
D
D
Q
R
Y
S
G
S
T
Y
L
S
Site 77
S803
T
A
D
D
Q
R
Y
S
G
S
T
Y
L
S
D
Site 78
S805
D
D
Q
R
Y
S
G
S
T
Y
L
S
D
P
R
Site 79
T806
D
Q
R
Y
S
G
S
T
Y
L
S
D
P
R
L
Site 80
Y807
Q
R
Y
S
G
S
T
Y
L
S
D
P
R
L
T
Site 81
S809
Y
S
G
S
T
Y
L
S
D
P
R
L
T
A
N
Site 82
T814
Y
L
S
D
P
R
L
T
A
N
G
F
K
I
K
Site 83
S875
C
R
P
R
K
V
I
S
Y
L
E
G
E
A
V
Site 84
Y876
R
P
R
K
V
I
S
Y
L
E
G
E
A
V
R
Site 85
S885
E
G
E
A
V
R
L
S
R
Q
L
P
M
Y
L
Site 86
Y891
L
S
R
Q
L
P
M
Y
L
S
K
E
D
I
Q
Site 87
S893
R
Q
L
P
M
Y
L
S
K
E
D
I
Q
D
I
Site 88
Y902
E
D
I
Q
D
I
I
Y
R
M
K
H
Q
F
G
Site 89
T926
R
P
F
F
H
H
L
T
Y
L
P
E
T
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation