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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMTN
Full Name:
Smoothelin
Alias:
SMOO; SMSMO
Type:
Cytoskeletal protein
Mass (Da):
99520
Number AA:
917
UniProt ID:
P53814
International Prot ID:
IPI00024007
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0007517
GO:0006939
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
A
E
R
R
R
I
R
S
A
I
R
E
L
Q
R
Site 2
S51
R
E
E
E
A
L
A
S
K
R
F
R
A
E
R
Site 3
S68
N
K
E
N
W
L
H
S
Q
Q
R
E
A
E
Q
Site 4
S88
R
L
A
G
Q
L
E
S
M
N
D
V
E
E
L
Site 5
Y105
L
L
R
S
A
G
E
Y
E
E
R
K
L
I
R
Site 6
Y133
A
T
L
A
G
R
L
Y
S
G
R
P
N
S
G
Site 7
S134
T
L
A
G
R
L
Y
S
G
R
P
N
S
G
S
Site 8
S139
L
Y
S
G
R
P
N
S
G
S
R
E
D
S
K
Site 9
S141
S
G
R
P
N
S
G
S
R
E
D
S
K
G
L
Site 10
S145
N
S
G
S
R
E
D
S
K
G
L
A
A
H
R
Site 11
T174
Q
A
E
V
S
K
P
T
P
T
P
E
G
T
S
Site 12
T176
E
V
S
K
P
T
P
T
P
E
G
T
S
Q
D
Site 13
T185
E
G
T
S
Q
D
V
T
T
V
T
L
L
L
R
Site 14
S197
L
L
R
A
P
P
G
S
T
S
S
S
P
A
S
Site 15
S199
R
A
P
P
G
S
T
S
S
S
P
A
S
P
S
Site 16
S200
A
P
P
G
S
T
S
S
S
P
A
S
P
S
S
Site 17
S201
P
P
G
S
T
S
S
S
P
A
S
P
S
S
S
Site 18
S204
S
T
S
S
S
P
A
S
P
S
S
S
P
T
P
Site 19
S206
S
S
S
P
A
S
P
S
S
S
P
T
P
A
S
Site 20
S207
S
S
P
A
S
P
S
S
S
P
T
P
A
S
P
Site 21
S208
S
P
A
S
P
S
S
S
P
T
P
A
S
P
E
Site 22
T210
A
S
P
S
S
S
P
T
P
A
S
P
E
P
P
Site 23
S213
S
S
S
P
T
P
A
S
P
E
P
P
L
E
P
Site 24
T227
P
A
E
A
Q
C
L
T
A
E
V
P
G
S
P
Site 25
S233
L
T
A
E
V
P
G
S
P
E
P
P
P
S
P
Site 26
S239
G
S
P
E
P
P
P
S
P
P
K
T
T
S
P
Site 27
T243
P
P
P
S
P
P
K
T
T
S
P
E
P
Q
E
Site 28
S245
P
S
P
P
K
T
T
S
P
E
P
Q
E
S
P
Site 29
S251
T
S
P
E
P
Q
E
S
P
T
L
P
S
T
E
Site 30
T253
P
E
P
Q
E
S
P
T
L
P
S
T
E
G
Q
Site 31
T257
E
S
P
T
L
P
S
T
E
G
Q
V
V
N
K
Site 32
S267
Q
V
V
N
K
L
L
S
G
P
K
E
T
P
A
Site 33
T272
L
L
S
G
P
K
E
T
P
A
A
Q
S
P
T
Site 34
S277
K
E
T
P
A
A
Q
S
P
T
R
G
P
S
D
Site 35
T279
T
P
A
A
Q
S
P
T
R
G
P
S
D
T
K
Site 36
S283
Q
S
P
T
R
G
P
S
D
T
K
R
A
D
V
Site 37
T285
P
T
R
G
P
S
D
T
K
R
A
D
V
A
G
Site 38
S299
G
P
R
P
C
Q
R
S
L
S
V
L
S
P
R
Site 39
S301
R
P
C
Q
R
S
L
S
V
L
S
P
R
Q
P
Site 40
S304
Q
R
S
L
S
V
L
T
P
R
Q
P
A
Q
N
Site 41
S314
Q
P
A
Q
N
R
E
S
T
P
L
A
S
G
P
Site 42
T315
P
A
Q
N
R
E
S
T
P
L
A
S
G
P
S
Site 43
S319
R
E
S
T
P
L
A
S
G
P
S
S
F
Q
R
Site 44
S322
T
P
L
A
S
G
P
S
S
F
Q
R
A
G
S
Site 45
S323
P
L
A
S
G
P
S
S
F
Q
R
A
G
S
V
Site 46
S329
S
S
F
Q
R
A
G
S
V
R
D
R
V
H
K
Site 47
T338
R
D
R
V
H
K
F
T
S
D
S
P
M
A
A
Site 48
S339
D
R
V
H
K
F
T
S
D
S
P
M
A
A
R
Site 49
S341
V
H
K
F
T
S
D
S
P
M
A
A
R
L
Q
Site 50
T351
A
A
R
L
Q
D
G
T
P
Q
A
A
L
S
P
Site 51
S357
G
T
P
Q
A
A
L
S
P
L
T
P
R
K
A
Site 52
T360
Q
A
A
L
S
P
L
T
P
R
K
A
P
G
P
Site 53
S384
L
L
Q
R
L
L
L
S
G
P
S
D
T
S
S
Site 54
S387
R
L
L
L
S
G
P
S
D
T
S
S
R
F
S
Site 55
T389
L
L
S
G
P
S
D
T
S
S
R
F
S
K
E
Site 56
S390
L
S
G
P
S
D
T
S
S
R
F
S
K
E
Q
Site 57
S391
S
G
P
S
D
T
S
S
R
F
S
K
E
Q
R
Site 58
S394
S
D
T
S
S
R
F
S
K
E
Q
R
G
V
A
Site 59
S409
Q
P
L
A
Q
L
R
S
C
P
Q
E
E
G
P
Site 60
S437
A
G
G
P
V
A
R
S
E
E
P
G
A
P
L
Site 61
S456
G
T
A
E
P
G
D
S
M
K
T
T
F
T
I
Site 62
T459
E
P
G
D
S
M
K
T
T
F
T
I
E
I
K
Site 63
T460
P
G
D
S
M
K
T
T
F
T
I
E
I
K
D
Site 64
T474
D
G
R
G
Q
A
S
T
G
R
V
L
L
P
T
Site 65
T481
T
G
R
V
L
L
P
T
G
N
Q
R
A
E
L
Site 66
S500
R
A
P
P
T
L
L
S
T
S
S
G
G
K
S
Site 67
S502
P
P
T
L
L
S
T
S
S
G
G
K
S
T
I
Site 68
S503
P
T
L
L
S
T
S
S
G
G
K
S
T
I
T
Site 69
S507
S
T
S
S
G
G
K
S
T
I
T
R
V
N
S
Site 70
T510
S
G
G
K
S
T
I
T
R
V
N
S
P
G
T
Site 71
S514
S
T
I
T
R
V
N
T
P
G
T
L
A
R
L
Site 72
T517
T
R
V
N
S
P
G
T
L
A
R
L
G
S
V
Site 73
S523
G
T
L
A
R
L
G
S
V
T
H
V
T
S
F
Site 74
S529
G
S
V
T
H
V
T
S
F
S
H
A
P
P
S
Site 75
S531
V
T
H
V
T
S
F
S
H
A
P
P
S
S
R
Site 76
S536
S
F
S
H
A
P
P
S
S
R
G
G
C
S
I
Site 77
S537
F
S
H
A
P
P
S
S
R
G
G
C
S
I
K
Site 78
S576
N
K
A
P
E
G
R
S
P
L
S
A
E
E
L
Site 79
S579
P
E
G
R
S
P
L
S
A
E
E
L
M
T
I
Site 80
S599
L
D
K
M
L
D
Q
S
T
D
F
E
E
R
K
Site 81
T645
P
G
E
G
R
G
N
T
A
T
E
T
T
T
R
Site 82
T647
E
G
R
G
N
T
A
T
E
T
T
T
R
H
S
Site 83
T649
R
G
N
T
A
T
E
T
T
T
R
H
S
Q
R
Site 84
T650
G
N
T
A
T
E
T
T
T
R
H
S
Q
R
A
Site 85
S654
T
E
T
T
T
R
H
S
Q
R
A
A
D
G
S
Site 86
S661
S
Q
R
A
A
D
G
S
A
V
S
T
V
T
K
Site 87
T665
A
D
G
S
A
V
S
T
V
T
K
T
E
R
L
Site 88
T669
A
V
S
T
V
T
K
T
E
R
L
V
H
S
N
Site 89
T679
L
V
H
S
N
D
G
T
R
T
A
R
T
T
T
Site 90
T684
D
G
T
R
T
A
R
T
T
T
V
E
S
S
F
Site 91
T685
G
T
R
T
A
R
T
T
T
V
E
S
S
F
V
Site 92
T686
T
R
T
A
R
T
T
T
V
E
S
S
F
V
R
Site 93
S690
R
T
T
T
V
E
S
S
F
V
R
R
S
E
N
Site 94
S695
E
S
S
F
V
R
R
S
E
N
G
S
G
S
T
Site 95
S699
V
R
R
S
E
N
G
S
G
S
T
M
M
Q
T
Site 96
S701
R
S
E
N
G
S
G
S
T
M
M
Q
T
K
T
Site 97
T706
S
G
S
T
M
M
Q
T
K
T
F
S
S
S
S
Site 98
T708
S
T
M
M
Q
T
K
T
F
S
S
S
S
S
S
Site 99
S710
M
M
Q
T
K
T
F
S
S
S
S
S
S
K
K
Site 100
S711
M
Q
T
K
T
F
S
S
S
S
S
S
K
K
M
Site 101
S712
Q
T
K
T
F
S
S
S
S
S
S
K
K
M
G
Site 102
S713
T
K
T
F
S
S
S
S
S
S
K
K
M
G
S
Site 103
S714
K
T
F
S
S
S
S
S
S
K
K
M
G
S
I
Site 104
S715
T
F
S
S
S
S
S
S
K
K
M
G
S
I
F
Site 105
S720
S
S
S
K
K
M
G
S
I
F
D
R
E
D
Q
Site 106
S729
F
D
R
E
D
Q
A
S
P
R
A
G
S
L
A
Site 107
S734
Q
A
S
P
R
A
G
S
L
A
A
L
E
K
R
Site 108
S754
K
E
L
M
K
A
Q
S
L
P
K
T
S
A
S
Site 109
T758
K
A
Q
S
L
P
K
T
S
A
S
Q
A
R
K
Site 110
S761
S
L
P
K
T
S
A
S
Q
A
R
K
A
M
I
Site 111
S779
E
K
E
G
A
A
G
S
P
G
G
P
R
A
A
Site 112
T791
R
A
A
V
Q
R
S
T
S
F
G
V
P
N
A
Site 113
S792
A
A
V
Q
R
S
T
S
F
G
V
P
N
A
N
Site 114
Y816
C
R
A
K
T
R
G
Y
E
H
V
D
I
Q
N
Site 115
S827
D
I
Q
N
F
S
S
S
W
S
D
G
M
A
F
Site 116
Y848
F
F
P
E
A
F
D
Y
G
Q
L
S
P
Q
N
Site 117
S852
A
F
D
Y
G
Q
L
S
P
Q
N
R
R
Q
N
Site 118
T896
P
D
P
K
C
V
F
T
Y
V
Q
S
L
Y
N
Site 119
Y897
D
P
K
C
V
F
T
Y
V
Q
S
L
Y
N
H
Site 120
Y902
F
T
Y
V
Q
S
L
Y
N
H
L
R
R
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation