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Updated November 2019
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Protein Info
Short Name:
TTC3
Full Name:
E3 ubiquitin-protein ligase TTC3
Alias:
DCRR1; RING finger protein 105; RNF105; Tetratricopeptide repeat 3; Tetratricopeptide repeat domain 3; TPR repeat 3; TPR repeat D; TPRD; TPRDI; TPRDII; TPRDIII
Type:
Unknown function
Mass (Da):
229891
Number AA:
2025
UniProt ID:
P53804
International Prot ID:
IPI00023977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
A
E
F
M
S
N
D
Y
V
R
V
T
Q
L
Y
Site 2
Y55
V
G
V
Q
Y
K
D
Y
I
Q
S
E
R
N
L
Site 3
S58
Q
Y
K
D
Y
I
Q
S
E
R
N
L
E
F
D
Site 4
S100
L
L
F
Q
H
Q
N
S
S
V
I
S
R
L
H
Site 5
S101
L
F
Q
H
Q
N
S
S
V
I
S
R
L
H
P
Site 6
S104
H
Q
N
S
S
V
I
S
R
L
H
P
C
V
D
Site 7
S118
D
A
N
N
S
R
A
S
E
I
N
L
K
K
L
Site 8
T221
N
L
L
E
E
L
K
T
Q
S
C
M
D
C
I
Site 9
S243
M
K
G
N
E
E
F
S
K
E
R
F
D
I
A
Site 10
Y268
R
P
E
N
Y
L
L
Y
G
N
R
A
L
C
F
Site 11
T292
L
G
D
G
K
R
A
T
I
L
K
N
T
W
P
Site 12
Y305
W
P
K
G
H
Y
R
Y
C
D
A
L
S
M
L
Site 13
S310
Y
R
Y
C
D
A
L
S
M
L
G
E
Y
D
W
Site 14
Y367
K
D
P
I
K
A
F
Y
E
N
R
A
Y
T
P
Site 15
Y372
A
F
Y
E
N
R
A
Y
T
P
R
S
L
S
A
Site 16
T373
F
Y
E
N
R
A
Y
T
P
R
S
L
S
A
P
Site 17
S376
N
R
A
Y
T
P
R
S
L
S
A
P
I
F
T
Site 18
S378
A
Y
T
P
R
S
L
S
A
P
I
F
T
T
S
Site 19
S385
S
A
P
I
F
T
T
S
L
N
F
V
E
K
E
Site 20
S429
C
D
C
H
P
E
F
S
P
P
S
S
Q
P
P
Site 21
S432
H
P
E
F
S
P
P
S
S
Q
P
P
K
H
K
Site 22
S433
P
E
F
S
P
P
S
S
Q
P
P
K
H
K
G
Site 23
S444
K
H
K
G
K
Q
K
S
R
N
N
E
S
E
K
Site 24
S449
Q
K
S
R
N
N
E
S
E
K
F
S
S
S
S
Site 25
S453
N
N
E
S
E
K
F
S
S
S
S
P
L
T
L
Site 26
S454
N
E
S
E
K
F
S
S
S
S
P
L
T
L
P
Site 27
S455
E
S
E
K
F
S
S
S
S
P
L
T
L
P
A
Site 28
S456
S
E
K
F
S
S
S
S
P
L
T
L
P
A
D
Site 29
T459
F
S
S
S
S
P
L
T
L
P
A
D
L
K
N
Site 30
S473
N
I
L
E
K
Q
F
S
K
S
S
R
A
A
H
Site 31
S475
L
E
K
Q
F
S
K
S
S
R
A
A
H
Q
D
Site 32
Y498
R
S
L
I
Q
D
G
Y
M
A
L
L
E
Q
R
Site 33
S508
L
L
E
Q
R
C
R
S
A
A
Q
A
F
T
E
Site 34
Y569
F
K
R
I
I
E
H
Y
P
S
E
G
L
D
C
Site 35
S571
R
I
I
E
H
Y
P
S
E
G
L
D
C
L
A
Site 36
Y586
Y
C
G
I
G
K
V
Y
L
K
K
N
R
F
L
Site 37
T604
N
H
F
E
K
A
R
T
L
I
Y
R
L
P
G
Site 38
S625
S
N
V
I
I
E
E
S
Q
P
Q
K
I
K
M
Site 39
Y665
G
Y
S
K
I
Q
I
Y
I
T
D
P
D
F
K
Site 40
T667
S
K
I
Q
I
Y
I
T
D
P
D
F
K
G
F
Site 41
T699
W
K
K
L
K
T
T
T
F
N
D
K
I
D
K
Site 42
S758
P
I
L
K
Q
K
C
S
S
L
E
K
L
R
L
Site 43
S759
I
L
K
Q
K
C
S
S
L
E
K
L
R
L
K
Site 44
S795
M
E
E
D
L
R
E
S
N
P
P
K
N
E
E
Site 45
T806
K
N
E
E
Q
K
E
T
V
D
N
V
Q
R
C
Site 46
S852
L
L
S
W
K
V
L
S
T
E
D
Y
T
T
C
Site 47
Y856
K
V
L
S
T
E
D
Y
T
T
C
F
S
S
R
Site 48
T857
V
L
S
T
E
D
Y
T
T
C
F
S
S
R
N
Site 49
T858
L
S
T
E
D
Y
T
T
C
F
S
S
R
N
F
Site 50
T886
Q
E
N
N
R
V
K
T
R
I
F
L
H
V
L
Site 51
S912
A
W
I
Q
K
L
N
S
F
G
L
D
A
T
G
Site 52
T918
N
S
F
G
L
D
A
T
G
T
F
F
S
R
Y
Site 53
S923
D
A
T
G
T
F
F
S
R
Y
G
A
S
L
K
Site 54
Y945
T
F
L
W
N
E
K
Y
G
H
K
L
D
S
I
Site 55
S951
K
Y
G
H
K
L
D
S
I
E
G
K
Q
L
D
Site 56
Y959
I
E
G
K
Q
L
D
Y
F
S
E
P
A
S
L
Site 57
S961
G
K
Q
L
D
Y
F
S
E
P
A
S
L
K
E
Site 58
S965
D
Y
F
S
E
P
A
S
L
K
E
A
R
C
L
Site 59
S988
D
K
F
P
A
L
H
S
A
L
D
E
F
F
D
Site 60
T1002
D
I
M
D
S
R
C
T
V
L
R
K
Q
D
S
Site 61
S1009
T
V
L
R
K
Q
D
S
G
E
A
P
F
S
S
Site 62
S1015
D
S
G
E
A
P
F
S
S
T
K
V
K
N
K
Site 63
S1023
S
T
K
V
K
N
K
S
K
K
K
K
P
K
D
Site 64
S1031
K
K
K
K
P
K
D
S
K
P
M
L
V
G
S
Site 65
S1038
S
K
P
M
L
V
G
S
G
T
T
S
V
T
S
Site 66
T1040
P
M
L
V
G
S
G
T
T
S
V
T
S
N
N
Site 67
S1042
L
V
G
S
G
T
T
S
V
T
S
N
N
E
I
Site 68
S1045
S
G
T
T
S
V
T
S
N
N
E
I
I
T
S
Site 69
S1052
S
N
N
E
I
I
T
S
S
E
D
H
S
N
R
Site 70
S1053
N
N
E
I
I
T
S
S
E
D
H
S
N
R
N
Site 71
S1057
I
T
S
S
E
D
H
S
N
R
N
S
D
S
A
Site 72
S1061
E
D
H
S
N
R
N
S
D
S
A
G
P
F
A
Site 73
S1063
H
S
N
R
N
S
D
S
A
G
P
F
A
V
P
Site 74
Y1084
V
E
E
F
E
A
L
Y
D
Q
H
S
N
E
Y
Site 75
S1088
E
A
L
Y
D
Q
H
S
N
E
Y
V
V
R
N
Site 76
Y1091
Y
D
Q
H
S
N
E
Y
V
V
R
N
K
K
L
Site 77
T1109
N
P
K
Q
K
C
S
T
L
Y
D
Y
F
S
Q
Site 78
Y1111
K
Q
K
C
S
T
L
Y
D
Y
F
S
Q
F
L
Site 79
Y1113
K
C
S
T
L
Y
D
Y
F
S
Q
F
L
E
E
Site 80
S1115
S
T
L
Y
D
Y
F
S
Q
F
L
E
E
H
G
Site 81
S1127
E
H
G
P
L
D
M
S
N
K
M
F
S
A
E
Site 82
Y1135
N
K
M
F
S
A
E
Y
E
F
F
P
E
E
T
Site 83
S1176
I
A
L
K
K
V
A
S
R
L
K
K
K
R
K
Site 84
T1189
R
K
K
K
N
I
K
T
K
V
E
E
I
S
K
Site 85
Y1200
E
I
S
K
A
G
E
Y
V
R
V
K
L
Q
L
Site 86
S1220
E
F
K
P
D
V
K
S
K
P
V
S
D
S
S
Site 87
S1224
D
V
K
S
K
P
V
S
D
S
S
S
A
P
A
Site 88
S1226
K
S
K
P
V
S
D
S
S
S
A
P
A
F
E
Site 89
S1227
S
K
P
V
S
D
S
S
S
A
P
A
F
E
N
Site 90
S1228
K
P
V
S
D
S
S
S
A
P
A
F
E
N
V
Site 91
S1241
N
V
K
P
K
P
V
S
A
N
S
P
K
P
A
Site 92
S1244
P
K
P
V
S
A
N
S
P
K
P
A
C
E
D
Site 93
S1258
D
V
K
A
K
P
V
S
D
N
S
S
R
Q
V
Site 94
S1261
A
K
P
V
S
D
N
S
S
R
Q
V
S
E
D
Site 95
S1262
K
P
V
S
D
N
S
S
R
Q
V
S
E
D
G
Site 96
S1266
D
N
S
S
R
Q
V
S
E
D
G
Q
P
K
G
Site 97
S1275
D
G
Q
P
K
G
V
S
S
N
S
P
K
P
G
Site 98
S1276
G
Q
P
K
G
V
S
S
N
S
P
K
P
G
S
Site 99
S1278
P
K
G
V
S
S
N
S
P
K
P
G
S
E
D
Site 100
S1283
S
N
S
P
K
P
G
S
E
D
A
N
Y
K
R
Site 101
Y1288
P
G
S
E
D
A
N
Y
K
R
V
S
C
N
S
Site 102
S1292
D
A
N
Y
K
R
V
S
C
N
S
P
K
P
V
Site 103
S1295
Y
K
R
V
S
C
N
S
P
K
P
V
L
E
D
Site 104
Y1307
L
E
D
V
K
P
T
Y
W
A
Q
S
H
L
V
Site 105
Y1317
Q
S
H
L
V
T
G
Y
C
T
Y
L
P
F
Q
Site 106
T1329
P
F
Q
R
F
D
I
T
Q
T
P
P
A
Y
I
Site 107
T1331
Q
R
F
D
I
T
Q
T
P
P
A
Y
I
N
V
Site 108
S1347
P
G
L
P
Q
Y
T
S
I
Y
T
P
L
A
S
Site 109
T1350
P
Q
Y
T
S
I
Y
T
P
L
A
S
L
S
P
Site 110
S1354
S
I
Y
T
P
L
A
S
L
S
P
E
Y
Q
L
Site 111
S1356
Y
T
P
L
A
S
L
S
P
E
Y
Q
L
P
R
Site 112
Y1359
L
A
S
L
S
P
E
Y
Q
L
P
R
S
V
P
Site 113
S1364
P
E
Y
Q
L
P
R
S
V
P
V
V
P
S
F
Site 114
Y1384
A
D
K
N
A
A
A
Y
F
E
G
H
H
L
N
Site 115
S1410
E
T
Q
I
L
E
G
S
L
G
I
S
V
K
S
Site 116
S1414
L
E
G
S
L
G
I
S
V
K
S
H
C
S
T
Site 117
S1417
S
L
G
I
S
V
K
S
H
C
S
T
G
D
A
Site 118
T1421
S
V
K
S
H
C
S
T
G
D
A
H
T
V
L
Site 119
T1426
C
S
T
G
D
A
H
T
V
L
S
E
S
N
R
Site 120
S1429
G
D
A
H
T
V
L
S
E
S
N
R
N
D
E
Site 121
S1431
A
H
T
V
L
S
E
S
N
R
N
D
E
H
C
Site 122
S1493
E
E
R
Q
G
E
I
S
R
I
E
K
E
H
Q
Site 123
Y1513
L
Q
E
V
Y
E
N
Y
E
Q
I
K
L
K
G
Site 124
S1541
H
L
E
E
N
K
I
S
K
T
E
L
D
W
F
Site 125
S1572
E
I
Q
E
R
L
K
S
L
K
K
K
I
K
K
Site 126
S1581
K
K
K
I
K
K
V
S
N
A
S
E
M
Y
T
Site 127
S1584
I
K
K
V
S
N
A
S
E
M
Y
T
Q
K
N
Site 128
T1588
S
N
A
S
E
M
Y
T
Q
K
N
D
G
K
E
Site 129
S1605
H
E
L
H
L
D
Q
S
L
E
I
S
N
T
L
Site 130
S1609
L
D
Q
S
L
E
I
S
N
T
L
T
N
E
K
Site 131
T1611
Q
S
L
E
I
S
N
T
L
T
N
E
K
M
K
Site 132
T1613
L
E
I
S
N
T
L
T
N
E
K
M
K
I
E
Site 133
Y1622
E
K
M
K
I
E
E
Y
I
K
K
G
K
E
D
Site 134
Y1630
I
K
K
G
K
E
D
Y
E
E
S
H
Q
R
A
Site 135
S1633
G
K
E
D
Y
E
E
S
H
Q
R
A
V
A
A
Site 136
S1643
R
A
V
A
A
E
V
S
V
L
E
N
W
K
E
Site 137
S1651
V
L
E
N
W
K
E
S
E
V
Y
K
L
Q
I
Site 138
Y1654
N
W
K
E
S
E
V
Y
K
L
Q
I
M
E
S
Site 139
S1661
Y
K
L
Q
I
M
E
S
Q
A
E
A
F
L
K
Site 140
Y1680
I
S
R
D
P
A
A
Y
P
D
M
E
S
D
I
Site 141
S1685
A
A
Y
P
D
M
E
S
D
I
R
S
W
E
L
Site 142
S1689
D
M
E
S
D
I
R
S
W
E
L
F
L
S
N
Site 143
S1695
R
S
W
E
L
F
L
S
N
V
T
K
E
I
E
Site 144
S1706
K
E
I
E
K
A
K
S
Q
F
E
E
Q
I
K
Site 145
S1719
I
K
A
I
K
N
G
S
R
L
S
E
L
S
K
Site 146
S1722
I
K
N
G
S
R
L
S
E
L
S
K
V
Q
I
Site 147
S1725
G
S
R
L
S
E
L
S
K
V
Q
I
S
E
L
Site 148
S1748
H
P
E
L
L
P
E
S
S
G
H
D
G
Q
G
Site 149
S1749
P
E
L
L
P
E
S
S
G
H
D
G
Q
G
L
Site 150
S1759
D
G
Q
G
L
V
T
S
A
S
D
V
T
G
N
Site 151
S1761
Q
G
L
V
T
S
A
S
D
V
T
G
N
H
A
Site 152
S1775
A
A
L
H
R
D
P
S
V
F
S
A
G
D
S
Site 153
S1778
H
R
D
P
S
V
F
S
A
G
D
S
P
G
E
Site 154
S1782
S
V
F
S
A
G
D
S
P
G
E
A
P
S
A
Site 155
S1816
R
A
G
Q
A
A
L
S
E
R
S
P
V
A
D
Site 156
S1819
Q
A
A
L
S
E
R
S
P
V
A
D
R
K
Q
Site 157
S1836
P
P
G
R
A
A
R
S
S
Q
S
P
K
K
P
Site 158
S1837
P
G
R
A
A
R
S
S
Q
S
P
K
K
P
F
Site 159
S1839
R
A
A
R
S
S
Q
S
P
K
K
P
F
N
S
Site 160
S1846
S
P
K
K
P
F
N
S
I
I
E
H
L
S
V
Site 161
S1872
G
F
I
K
K
V
R
S
K
N
K
N
S
L
S
Site 162
S1877
V
R
S
K
N
K
N
S
L
S
G
L
S
I
D
Site 163
S1879
S
K
N
K
N
S
L
S
G
L
S
I
D
E
I
Site 164
T1891
D
E
I
V
Q
R
V
T
E
H
I
L
D
E
Q
Site 165
T1911
N
P
G
K
D
K
R
T
Y
E
P
S
S
A
T
Site 166
Y1912
P
G
K
D
K
R
T
Y
E
P
S
S
A
T
P
Site 167
S1915
D
K
R
T
Y
E
P
S
S
A
T
P
V
T
R
Site 168
S1916
K
R
T
Y
E
P
S
S
A
T
P
V
T
R
S
Site 169
T1918
T
Y
E
P
S
S
A
T
P
V
T
R
S
S
Q
Site 170
T1921
P
S
S
A
T
P
V
T
R
S
S
Q
G
S
P
Site 171
S1923
S
A
T
P
V
T
R
S
S
Q
G
S
P
S
V
Site 172
S1924
A
T
P
V
T
R
S
S
Q
G
S
P
S
V
V
Site 173
S1927
V
T
R
S
S
Q
G
S
P
S
V
V
V
A
P
Site 174
S1929
R
S
S
Q
G
S
P
S
V
V
V
A
P
S
P
Site 175
S1935
P
S
V
V
V
A
P
S
P
K
T
K
G
Q
K
Site 176
T1938
V
V
A
P
S
P
K
T
K
G
Q
K
A
E
D
Site 177
Y1978
V
L
K
C
G
H
K
Y
H
K
G
C
F
K
Q
Site 178
T2003
C
Q
G
R
D
L
L
T
E
E
S
P
S
G
R
Site 179
S2006
R
D
L
L
T
E
E
S
P
S
G
R
G
W
P
Site 180
S2008
L
L
T
E
E
S
P
S
G
R
G
W
P
S
Q
Site 181
S2014
P
S
G
R
G
W
P
S
Q
N
Q
E
L
P
S
Site 182
S2021
S
Q
N
Q
E
L
P
S
C
S
S
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation