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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTSC
Full Name:
Dipeptidyl peptidase 1
Alias:
Cathepsin C;Cathepsin J;Dipeptidyl peptidase I;Dipeptidyl transferase;Dipeptidyl peptidase I exclusion domain chain;Dipeptidyl peptidase I heavy chain;Dipeptidyl peptidase I light chain
Type:
Mass (Da):
51842
Number AA:
463
UniProt ID:
P53634
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
D
G
A
V
R
C
D
T
P
A
N
C
T
Y
L
Site 2
Y32
D
T
P
A
N
C
T
Y
L
D
L
L
G
T
W
Site 3
S48
F
Q
V
G
S
S
G
S
Q
R
D
V
N
C
S
Site 4
S55
S
Q
R
D
V
N
C
S
V
M
G
P
Q
E
K
Site 5
T73
V
Y
L
Q
K
L
D
T
A
Y
D
D
L
G
N
Site 6
Y75
L
Q
K
L
D
T
A
Y
D
D
L
G
N
S
G
Site 7
Y107
K
W
F
A
F
F
K
Y
K
E
E
G
S
K
V
Site 8
T116
E
E
G
S
K
V
T
T
Y
C
N
E
T
M
T
Site 9
Y117
E
G
S
K
V
T
T
Y
C
N
E
T
M
T
G
Site 10
S146
G
K
K
V
G
T
A
S
E
N
V
Y
V
N
T
Site 11
Y150
G
T
A
S
E
N
V
Y
V
N
T
A
H
L
K
Site 12
S159
N
T
A
H
L
K
N
S
Q
E
K
Y
S
N
R
Site 13
Y163
L
K
N
S
Q
E
K
Y
S
N
R
L
Y
K
Y
Site 14
S164
K
N
S
Q
E
K
Y
S
N
R
L
Y
K
Y
D
Site 15
Y168
E
K
Y
S
N
R
L
Y
K
Y
D
H
N
F
V
Site 16
Y170
Y
S
N
R
L
Y
K
Y
D
H
N
F
V
K
A
Site 17
T188
I
Q
K
S
W
T
A
T
T
Y
M
E
Y
E
T
Site 18
Y190
K
S
W
T
A
T
T
Y
M
E
Y
E
T
L
T
Site 19
Y193
T
A
T
T
Y
M
E
Y
E
T
L
T
L
G
D
Site 20
S205
L
G
D
M
I
R
R
S
G
G
H
S
R
K
I
Site 21
S209
I
R
R
S
G
G
H
S
R
K
I
P
R
P
K
Site 22
T221
R
P
K
P
A
P
L
T
A
E
I
Q
Q
K
I
Site 23
S247
V
H
G
I
N
F
V
S
P
V
R
N
Q
A
S
Site 24
S254
S
P
V
R
N
Q
A
S
C
G
S
C
Y
S
F
Site 25
S257
R
N
Q
A
S
C
G
S
C
Y
S
F
A
S
M
Site 26
T275
E
A
R
I
R
I
L
T
N
N
S
Q
T
P
I
Site 27
S278
I
R
I
L
T
N
N
S
Q
T
P
I
L
S
P
Site 28
T280
I
L
T
N
N
S
Q
T
P
I
L
S
P
Q
E
Site 29
S284
N
S
Q
T
P
I
L
S
P
Q
E
V
V
S
C
Site 30
S290
L
S
P
Q
E
V
V
S
C
S
Q
Y
A
Q
G
Site 31
S292
P
Q
E
V
V
S
C
S
Q
Y
A
Q
G
C
E
Site 32
Y294
E
V
V
S
C
S
Q
Y
A
Q
G
C
E
G
G
Site 33
T325
E
E
A
C
F
P
Y
T
G
T
D
S
P
C
K
Site 34
S329
F
P
Y
T
G
T
D
S
P
C
K
M
K
E
D
Site 35
Y340
M
K
E
D
C
F
R
Y
Y
S
S
E
Y
H
Y
Site 36
Y341
K
E
D
C
F
R
Y
Y
S
S
E
Y
H
Y
V
Site 37
Y345
F
R
Y
Y
S
S
E
Y
H
Y
V
G
G
F
Y
Site 38
Y347
Y
Y
S
S
E
Y
H
Y
V
G
G
F
Y
G
G
Site 39
Y352
Y
H
Y
V
G
G
F
Y
G
G
C
N
E
A
L
Site 40
Y383
V
Y
D
D
F
L
H
Y
K
K
G
I
Y
H
H
Site 41
Y388
L
H
Y
K
K
G
I
Y
H
H
T
G
L
R
D
Site 42
T391
K
K
G
I
Y
H
H
T
G
L
R
D
P
F
N
Site 43
S416
L
V
G
Y
G
T
D
S
A
S
G
M
D
Y
W
Site 44
Y422
D
S
A
S
G
M
D
Y
W
I
V
K
N
S
W
Site 45
Y438
T
G
W
G
E
N
G
Y
F
R
I
R
R
G
T
Site 46
T445
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Site 47
S452
T
D
E
C
A
I
E
S
I
A
V
A
A
T
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation