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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKR1C2
Full Name:
Aldo-keto reductase family 1 member C2
Alias:
3-alpha hydroxysteroid dehydrogenase, type III; 3-alpha-HSD3; AK1C2; AKR1C-pseudo; Aldo-keto reductase family 1, member C2; BABP; Bile acid binding protein; Chlordecone reductase homolog HAKRD; DD; DD/BABP; DD2; DDH2; Dihydrodiol dehydrogenase 2; EC 1.-.-.-; EC 1.1.1.213; EC 1.3.1.20; HAKRD; MCDR2
Type:
Oxidoreductase; EC 1.3.1.20; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.-.-.-; EC 1.1.1.-; EC 1.1.1.213
Mass (Da):
36735
Number AA:
323
UniProt ID:
P52895
International Prot ID:
IPI00005668
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047026
GO:0032052
GO:0047115
PhosphoSite+
KinaseNET
Biological Process:
GO:0007586
GO:0055114
GO:0006693
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y5
_
_
_
M
D
S
K
Y
Q
C
V
K
L
N
D
Site 2
T23
M
P
V
L
G
F
G
T
Y
A
P
A
E
V
P
Site 3
Y24
P
V
L
G
F
G
T
Y
A
P
A
E
V
P
K
Site 4
S32
A
P
A
E
V
P
K
S
K
A
L
E
A
V
K
Site 5
Y55
H
I
D
S
A
H
V
Y
N
N
E
E
Q
V
G
Site 6
S73
R
S
K
I
A
D
G
S
V
K
R
E
D
I
F
Site 7
Y81
V
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
Site 8
T82
K
R
E
D
I
F
Y
T
S
K
L
W
S
N
S
Site 9
S87
F
Y
T
S
K
L
W
S
N
S
H
R
P
E
L
Site 10
S89
T
S
K
L
W
S
N
S
H
R
P
E
L
V
R
Site 11
Y110
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
Site 12
S162
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
Site 13
Y184
L
N
K
P
G
L
K
Y
K
P
V
C
N
Q
V
Site 14
Y196
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
Site 15
S208
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Site 16
S221
V
A
Y
S
A
L
G
S
H
R
E
E
P
W
V
Site 17
S232
E
P
W
V
D
P
N
S
P
V
L
L
E
D
P
Site 18
T251
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Site 19
S271
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Site 20
Y272
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
Site 21
T289
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
Site 22
Y305
G
L
N
R
N
V
R
Y
L
T
L
D
I
F
A
Site 23
T307
N
R
N
V
R
Y
L
T
L
D
I
F
A
G
P
Site 24
Y317
I
F
A
G
P
P
N
Y
P
F
S
D
E
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation