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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NDST1
Full Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Alias:
EC 2.8.2.-; EC 2.8.2.8; EC 3.-.-.-; Glucosaminyl N-deacetylase/N-sulfotransferase 1; Heparan sulfate N-sulfotransferase 1; HSNST 1; HSST; HSST1
Type:
Golgi membrane, Membrane, Integral to membrane, Golgi apparatus protein
Mass (Da):
100868
Number AA:
882
UniProt ID:
P52848
International Prot ID:
IPI00784368
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0015016
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0015012
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
S
V
F
I
S
A
Y
Y
L
Y
G
W
K
R
G
Site 2
Y39
F
I
S
A
Y
Y
L
Y
G
W
K
R
G
L
E
Site 3
S48
W
K
R
G
L
E
P
S
A
D
A
P
E
P
D
Site 4
T77
L
K
P
V
Q
A
A
T
P
S
R
T
D
P
L
Site 5
S79
P
V
Q
A
A
T
P
S
R
T
D
P
L
V
L
Site 6
S106
E
V
V
A
I
L
E
S
S
R
F
K
Y
R
T
Site 7
Y111
L
E
S
S
R
F
K
Y
R
T
E
I
A
P
G
Site 8
T113
S
S
R
F
K
Y
R
T
E
I
A
P
G
K
G
Site 9
T124
P
G
K
G
D
M
P
T
L
T
D
K
G
R
G
Site 10
T126
K
G
D
M
P
T
L
T
D
K
G
R
G
R
F
Site 11
Y144
I
Y
E
N
I
L
K
Y
V
N
L
D
A
W
N
Site 12
Y158
N
R
E
L
L
D
K
Y
C
V
A
Y
G
V
G
Site 13
S179
A
N
E
N
S
L
L
S
A
Q
L
K
G
F
P
Site 14
S199
N
L
G
L
K
D
C
S
I
N
P
K
S
P
L
Site 15
S204
D
C
S
I
N
P
K
S
P
L
L
Y
V
T
R
Site 16
Y208
N
P
K
S
P
L
L
Y
V
T
R
P
S
E
V
Site 17
T226
V
L
P
G
E
D
W
T
V
F
Q
S
N
H
S
Site 18
T234
V
F
Q
S
N
H
S
T
Y
E
P
V
L
L
A
Site 19
Y235
F
Q
S
N
H
S
T
Y
E
P
V
L
L
A
K
Site 20
T243
E
P
V
L
L
A
K
T
R
S
S
E
S
I
P
Site 21
S245
V
L
L
A
K
T
R
S
S
E
S
I
P
H
L
Site 22
S246
L
L
A
K
T
R
S
S
E
S
I
P
H
L
G
Site 23
S248
A
K
T
R
S
S
E
S
I
P
H
L
G
A
D
Site 24
S307
F
L
T
G
K
R
L
S
L
P
L
D
R
Y
I
Site 25
T353
R
A
H
I
P
N
F
T
F
N
L
G
Y
S
G
Site 26
S403
P
H
L
F
H
N
Q
S
V
L
A
E
Q
M
A
Site 27
Y427
G
I
P
T
D
M
G
Y
A
V
A
P
H
H
S
Site 28
Y437
A
P
H
H
S
G
V
Y
P
V
H
V
Q
L
Y
Site 29
T456
Q
V
W
S
I
R
V
T
S
T
E
E
Y
P
H
Site 30
S457
V
W
S
I
R
V
T
S
T
E
E
Y
P
H
L
Site 31
Y461
R
V
T
S
T
E
E
Y
P
H
L
K
P
A
R
Site 32
Y469
P
H
L
K
P
A
R
Y
R
R
G
F
I
H
N
Site 33
Y495
L
F
T
H
T
I
F
Y
N
E
Y
P
G
G
S
Site 34
Y498
H
T
I
F
Y
N
E
Y
P
G
G
S
S
E
L
Site 35
S502
Y
N
E
Y
P
G
G
S
S
E
L
D
K
I
I
Site 36
S503
N
E
Y
P
G
G
S
S
E
L
D
K
I
I
N
Site 37
T528
N
P
I
S
I
F
M
T
H
L
S
N
Y
G
N
Site 38
Y533
F
M
T
H
L
S
N
Y
G
N
D
R
L
G
L
Site 39
Y541
G
N
D
R
L
G
L
Y
T
F
K
H
L
V
R
Site 40
T542
N
D
R
L
G
L
Y
T
F
K
H
L
V
R
F
Site 41
S552
H
L
V
R
F
L
H
S
W
T
N
L
R
L
Q
Site 42
Y570
P
V
Q
L
A
Q
K
Y
F
Q
I
F
S
E
E
Site 43
T600
D
I
W
S
K
E
K
T
C
D
R
F
P
K
L
Site 44
S631
L
G
M
H
P
D
L
S
S
N
Y
P
S
S
E
Site 45
S632
G
M
H
P
D
L
S
S
N
Y
P
S
S
E
T
Site 46
Y634
H
P
D
L
S
S
N
Y
P
S
S
E
T
F
E
Site 47
S636
D
L
S
S
N
Y
P
S
S
E
T
F
E
E
I
Site 48
S637
L
S
S
N
Y
P
S
S
E
T
F
E
E
I
Q
Site 49
T639
S
N
Y
P
S
S
E
T
F
E
E
I
Q
F
F
Site 50
T668
F
F
P
I
P
S
N
T
T
S
D
F
Y
F
E
Site 51
S670
P
I
P
S
N
T
T
S
D
F
Y
F
E
K
S
Site 52
Y673
S
N
T
T
S
D
F
Y
F
E
K
S
A
N
Y
Site 53
S677
S
D
F
Y
F
E
K
S
A
N
Y
F
D
S
E
Site 54
Y680
Y
F
E
K
S
A
N
Y
F
D
S
E
V
A
P
Site 55
S683
K
S
A
N
Y
F
D
S
E
V
A
P
R
R
A
Site 56
Y711
I
N
P
A
D
R
A
Y
S
W
Y
Q
H
Q
R
Site 57
S712
N
P
A
D
R
A
Y
S
W
Y
Q
H
Q
R
A
Site 58
Y714
A
D
R
A
Y
S
W
Y
Q
H
Q
R
A
H
D
Site 59
Y728
D
D
P
V
A
L
K
Y
T
F
H
E
V
I
T
Site 60
S742
T
A
G
S
D
A
S
S
K
L
R
A
L
Q
N
Site 61
Y804
G
V
T
N
T
I
D
Y
H
K
T
L
A
F
D
Site 62
T807
N
T
I
D
Y
H
K
T
L
A
F
D
P
K
K
Site 63
T826
Q
L
L
E
G
G
K
T
K
C
L
G
K
S
K
Site 64
S832
K
T
K
C
L
G
K
S
K
G
R
K
Y
P
E
Site 65
Y837
G
K
S
K
G
R
K
Y
P
E
M
D
L
D
S
Site 66
S844
Y
P
E
M
D
L
D
S
R
A
F
L
K
D
Y
Site 67
Y851
S
R
A
F
L
K
D
Y
Y
R
D
H
N
I
E
Site 68
Y852
R
A
F
L
K
D
Y
Y
R
D
H
N
I
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation