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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HK3
Full Name:
Hexokinase-3
Alias:
Hexokinase type III
Type:
Mass (Da):
99025
Number AA:
923
UniProt ID:
P52790
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
S
I
G
S
S
G
L
R
Q
G
E
E
Site 2
T15
G
L
R
Q
G
E
E
T
L
S
C
S
E
E
G
Site 3
S17
R
Q
G
E
E
T
L
S
C
S
E
E
G
L
P
Site 4
S19
G
E
E
T
L
S
C
S
E
E
G
L
P
G
P
Site 5
S27
E
E
G
L
P
G
P
S
D
S
S
E
L
V
Q
Site 6
S29
G
L
P
G
P
S
D
S
S
E
L
V
Q
E
C
Site 7
S30
L
P
G
P
S
D
S
S
E
L
V
Q
E
C
L
Site 8
S53
Q
L
Q
Q
I
Q
A
S
L
L
G
S
M
E
Q
Site 9
S67
Q
A
L
R
G
Q
A
S
P
A
P
A
V
R
M
Site 10
T77
P
A
V
R
M
L
P
T
Y
V
G
S
T
P
H
Site 11
Y78
A
V
R
M
L
P
T
Y
V
G
S
T
P
H
G
Site 12
S81
M
L
P
T
Y
V
G
S
T
P
H
G
T
E
Q
Site 13
T82
L
P
T
Y
V
G
S
T
P
H
G
T
E
Q
G
Site 14
T86
V
G
S
T
P
H
G
T
E
Q
G
D
F
V
V
Site 15
T99
V
V
L
E
L
G
A
T
G
A
S
L
R
V
L
Site 16
S122
G
H
R
V
E
P
R
S
Q
E
F
V
I
P
Q
Site 17
S166
Q
G
L
Q
L
G
F
S
F
S
F
P
C
H
Q
Site 18
S179
H
Q
T
G
L
D
R
S
T
L
I
S
W
T
K
Site 19
T180
Q
T
G
L
D
R
S
T
L
I
S
W
T
K
G
Site 20
S183
L
D
R
S
T
L
I
S
W
T
K
G
F
R
C
Site 21
S191
W
T
K
G
F
R
C
S
G
V
E
G
Q
D
V
Site 22
Y251
D
T
G
T
N
A
C
Y
M
E
E
A
R
H
V
Site 23
S271
D
R
G
R
V
C
V
S
V
E
W
G
S
F
S
Site 24
S278
S
V
E
W
G
S
F
S
D
D
G
A
L
G
P
Site 25
T293
V
L
T
T
F
D
H
T
L
D
H
E
S
L
N
Site 26
S298
D
H
T
L
D
H
E
S
L
N
P
G
A
Q
R
Site 27
Y314
E
K
M
I
G
G
L
Y
L
G
E
L
V
R
L
Site 28
T360
A
E
M
E
D
P
S
T
G
A
A
R
V
H
A
Site 29
S438
E
R
H
P
R
F
C
S
V
L
Q
G
T
V
M
Site 30
T486
H
R
R
L
L
E
E
T
L
A
P
F
R
L
N
Site 31
S517
K
G
L
R
G
E
A
S
S
L
R
M
L
P
T
Site 32
S518
G
L
R
G
E
A
S
S
L
R
M
L
P
T
F
Site 33
T524
S
S
L
R
M
L
P
T
F
V
R
A
T
P
D
Site 34
T529
L
P
T
F
V
R
A
T
P
D
G
S
E
R
G
Site 35
S533
V
R
A
T
P
D
G
S
E
R
G
D
F
L
A
Site 36
S567
Q
I
T
S
E
I
Y
S
I
P
E
T
V
A
Q
Site 37
T571
E
I
Y
S
I
P
E
T
V
A
Q
G
S
G
Q
Site 38
S598
F
Q
Q
K
Q
G
L
S
G
Q
S
L
P
L
G
Site 39
T607
Q
S
L
P
L
G
F
T
F
S
F
P
C
R
Q
Site 40
S632
W
T
K
G
F
K
A
S
D
C
E
G
Q
D
V
Site 41
T648
S
L
L
R
E
A
I
T
R
R
Q
A
V
E
L
Site 42
Y673
G
T
M
M
S
C
G
Y
E
D
P
R
C
E
I
Site 43
Y692
G
T
G
T
N
A
C
Y
M
E
E
L
R
N
V
Site 44
S723
G
A
F
G
D
D
G
S
L
A
M
L
S
T
R
Site 45
S734
L
S
T
R
F
D
A
S
V
D
Q
A
S
I
N
Site 46
S739
D
A
S
V
D
Q
A
S
I
N
P
G
K
Q
R
Site 47
Y755
E
K
M
I
S
G
M
Y
L
G
E
I
V
R
H
Site 48
T784
Q
Q
I
Q
R
L
Q
T
R
D
I
F
K
T
K
Site 49
T790
Q
T
R
D
I
F
K
T
K
F
L
S
E
I
E
Site 50
S794
I
F
K
T
K
F
L
S
E
I
E
S
D
S
L
Site 51
S798
K
F
L
S
E
I
E
S
D
S
L
A
L
R
Q
Site 52
S800
L
S
E
I
E
S
D
S
L
A
L
R
Q
V
R
Site 53
T869
V
S
V
G
V
D
G
T
L
Y
K
L
H
P
R
Site 54
Y871
V
G
V
D
G
T
L
Y
K
L
H
P
R
F
S
Site 55
T884
F
S
S
L
V
A
A
T
V
R
E
L
A
P
R
Site 56
T895
L
A
P
R
C
V
V
T
F
L
Q
S
E
D
G
Site 57
S899
C
V
V
T
F
L
Q
S
E
D
G
S
G
K
G
Site 58
S903
F
L
Q
S
E
D
G
S
G
K
G
A
A
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation