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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK3
Full Name:
Serine/threonine-protein kinase Nek3
Alias:
EC 2.7.11.1; HSPK 36; NimA-related protein kinase 3
Type:
Protein kinase, tyrosine (non-receptor); EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family
Mass (Da):
57705
Number AA:
506
UniProt ID:
P51956
International Prot ID:
IPI00465101
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
K
E
I
R
L
P
K
S
F
S
N
T
Q
N
S
Site 2
S42
I
R
L
P
K
S
F
S
N
T
Q
N
S
R
K
Site 3
T44
L
P
K
S
F
S
N
T
Q
N
S
R
K
E
A
Site 4
S47
S
F
S
N
T
Q
N
S
R
K
E
A
V
L
L
Site 5
S68
N
I
V
A
F
K
E
S
F
E
A
E
G
H
L
Site 6
S130
V
L
H
R
D
I
K
S
K
N
I
F
L
T
Q
Site 7
T136
K
S
K
N
I
F
L
T
Q
N
G
K
V
K
L
Site 8
S148
V
K
L
G
D
F
G
S
A
R
L
L
S
N
P
Site 9
Y167
C
T
Y
V
G
T
P
Y
Y
V
P
P
E
I
W
Site 10
Y168
T
Y
V
G
T
P
Y
Y
V
P
P
E
I
W
E
Site 11
Y179
E
I
W
E
N
L
P
Y
N
N
K
S
D
I
W
Site 12
S220
K
V
C
Q
G
C
I
S
P
L
P
S
H
Y
S
Site 13
S224
G
C
I
S
P
L
P
S
H
Y
S
Y
E
L
Q
Site 14
S227
S
P
L
P
S
H
Y
S
Y
E
L
Q
F
L
V
Site 15
Y228
P
L
P
S
H
Y
S
Y
E
L
Q
F
L
V
K
Site 16
S243
Q
M
F
K
R
N
P
S
H
R
P
S
A
T
T
Site 17
S247
R
N
P
S
H
R
P
S
A
T
T
L
L
S
R
Site 18
T249
P
S
H
R
P
S
A
T
T
L
L
S
R
G
I
Site 19
T250
S
H
R
P
S
A
T
T
L
L
S
R
G
I
V
Site 20
S253
P
S
A
T
T
L
L
S
R
G
I
V
A
R
L
Site 21
T288
I
K
N
S
K
H
N
T
P
R
K
K
T
N
P
Site 22
T293
H
N
T
P
R
K
K
T
N
P
S
R
I
R
I
Site 23
S296
P
R
K
K
T
N
P
S
R
I
R
I
A
L
G
Site 24
S307
I
A
L
G
N
E
A
S
T
V
Q
E
E
E
Q
Site 25
S319
E
E
Q
D
R
K
G
S
H
T
D
L
E
S
I
Site 26
T321
Q
D
R
K
G
S
H
T
D
L
E
S
I
N
E
Site 27
S325
G
S
H
T
D
L
E
S
I
N
E
N
L
V
E
Site 28
S333
I
N
E
N
L
V
E
S
A
L
R
R
V
N
R
Site 29
S347
R
E
E
K
G
N
K
S
V
H
L
R
K
A
S
Site 30
S354
S
V
H
L
R
K
A
S
S
P
N
L
H
R
R
Site 31
S355
V
H
L
R
K
A
S
S
P
N
L
H
R
R
Q
Site 32
S384
N
A
S
I
L
T
S
S
L
T
A
E
D
D
R
Site 33
T386
S
I
L
T
S
S
L
T
A
E
D
D
R
G
G
Site 34
S394
A
E
D
D
R
G
G
S
V
I
K
Y
S
K
N
Site 35
Y398
R
G
G
S
V
I
K
Y
S
K
N
T
T
R
K
Site 36
S399
G
G
S
V
I
K
Y
S
K
N
T
T
R
K
Q
Site 37
T411
R
K
Q
W
L
K
E
T
P
D
T
L
L
N
I
Site 38
T414
W
L
K
E
T
P
D
T
L
L
N
I
L
K
N
Site 39
Y431
L
S
L
A
F
Q
T
Y
T
I
Y
R
P
G
S
Site 40
T432
S
L
A
F
Q
T
Y
T
I
Y
R
P
G
S
E
Site 41
Y434
A
F
Q
T
Y
T
I
Y
R
P
G
S
E
G
F
Site 42
S438
Y
T
I
Y
R
P
G
S
E
G
F
L
K
G
P
Site 43
S447
G
F
L
K
G
P
L
S
E
E
T
E
A
S
D
Site 44
S453
L
S
E
E
T
E
A
S
D
S
V
D
G
G
H
Site 45
S455
E
E
T
E
A
S
D
S
V
D
G
G
H
D
S
Site 46
S462
S
V
D
G
G
H
D
S
V
I
L
D
P
E
R
Site 47
T479
P
G
L
D
E
E
D
T
D
F
E
E
E
D
D
Site 48
S492
D
D
N
P
D
W
V
S
E
L
K
K
R
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation