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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYGF
Full Name:
Retinal guanylyl cyclase 2
Alias:
EC 4.6.1.2; GC-F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; GUC2F; GUCY2F; RETGC-2; Rod outer segment membrane guanylate cyclase 2; ROS-GC2
Type:
Membrane, Integral plasma membrane, Nuclear outer membrane protein
Mass (Da):
124822
Number AA:
1108
UniProt ID:
P51841
International Prot ID:
IPI00020942
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005640
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0004383
PhosphoSite+
KinaseNET
Biological Process:
GO:0006182
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S522
F
I
N
P
H
F
G
S
K
R
G
S
R
A
S
Site 2
S526
H
F
G
S
K
R
G
S
R
A
S
V
S
F
Q
Site 3
S529
S
K
R
G
S
R
A
S
V
S
F
Q
I
T
S
Site 4
S531
R
G
S
R
A
S
V
S
F
Q
I
T
S
E
V
Site 5
T535
A
S
V
S
F
Q
I
T
S
E
V
Q
S
G
R
Site 6
S536
S
V
S
F
Q
I
T
S
E
V
Q
S
G
R
S
Site 7
S540
Q
I
T
S
E
V
Q
S
G
R
S
P
R
L
S
Site 8
S543
S
E
V
Q
S
G
R
S
P
R
L
S
F
S
S
Site 9
S547
S
G
R
S
P
R
L
S
F
S
S
G
S
L
T
Site 10
S549
R
S
P
R
L
S
F
S
S
G
S
L
T
P
A
Site 11
S550
S
P
R
L
S
F
S
S
G
S
L
T
P
A
T
Site 12
S552
R
L
S
F
S
S
G
S
L
T
P
A
T
Y
E
Site 13
T554
S
F
S
S
G
S
L
T
P
A
T
Y
E
N
S
Site 14
T557
S
G
S
L
T
P
A
T
Y
E
N
S
N
I
A
Site 15
Y558
G
S
L
T
P
A
T
Y
E
N
S
N
I
A
I
Site 16
Y566
E
N
S
N
I
A
I
Y
E
G
D
W
V
W
L
Site 17
S586
G
D
F
G
D
L
K
S
I
K
S
R
A
S
D
Site 18
S589
G
D
L
K
S
I
K
S
R
A
S
D
V
F
E
Site 19
S592
K
S
I
K
S
R
A
S
D
V
F
E
M
M
K
Site 20
S630
T
E
F
C
S
R
G
S
L
E
D
I
L
T
N
Site 21
T636
G
S
L
E
D
I
L
T
N
Q
D
V
K
L
D
Site 22
Y660
D
L
I
K
G
M
K
Y
L
H
H
R
E
F
V
Site 23
S673
F
V
H
G
R
L
K
S
R
N
C
V
V
D
G
Site 24
S701
I
L
E
M
L
R
L
S
E
E
E
S
S
M
E
Site 25
S705
L
R
L
S
E
E
E
S
S
M
E
E
L
L
W
Site 26
S706
R
L
S
E
E
E
S
S
M
E
E
L
L
W
T
Site 27
S724
L
L
R
A
P
R
G
S
R
L
G
S
F
A
G
Site 28
S728
P
R
G
S
R
L
G
S
F
A
G
D
V
Y
S
Site 29
Y771
L
K
K
P
P
P
V
Y
R
P
V
V
P
P
E
Site 30
T801
E
A
A
E
Q
R
P
T
F
D
E
I
F
N
Q
Site 31
T811
E
I
F
N
Q
F
K
T
F
N
K
G
K
K
T
Site 32
T818
T
F
N
K
G
K
K
T
N
I
I
D
S
M
L
Site 33
S823
K
K
T
N
I
I
D
S
M
L
R
M
L
E
Q
Site 34
Y831
M
L
R
M
L
E
Q
Y
S
S
N
L
E
D
L
Site 35
S833
R
M
L
E
Q
Y
S
S
N
L
E
D
L
I
R
Site 36
T843
E
D
L
I
R
E
R
T
E
E
L
E
I
E
K
Site 37
T853
L
E
I
E
K
Q
K
T
E
K
L
L
T
Q
M
Site 38
T858
Q
K
T
E
K
L
L
T
Q
M
L
P
P
S
V
Site 39
S864
L
T
Q
M
L
P
P
S
V
A
E
S
L
K
K
Site 40
S868
L
P
P
S
V
A
E
S
L
K
K
G
C
T
V
Site 41
T874
E
S
L
K
K
G
C
T
V
E
P
E
G
F
D
Site 42
Y926
I
I
G
S
H
D
V
Y
K
V
E
T
I
G
D
Site 43
S947
G
L
P
K
R
N
G
S
R
H
A
A
E
I
A
Site 44
T966
D
I
L
S
S
V
G
T
F
K
M
R
H
M
P
Site 45
S1011
G
D
T
V
N
T
A
S
R
M
E
S
T
G
L
Site 46
S1015
N
T
A
S
R
M
E
S
T
G
L
P
Y
R
I
Site 47
T1047
E
V
E
L
R
G
R
T
E
L
K
G
K
G
T
Site 48
T1057
K
G
K
G
T
E
E
T
F
W
L
I
G
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation