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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRKX
Full Name:
Serine/threonine-protein kinase PRKX
Alias:
EC 2.7.11.1; PKX1
Type:
Protein kinase, Ser/Thr, AGC group, PKA family
Mass (Da):
40896
Number AA:
358
UniProt ID:
P51817
International Prot ID:
IPI00020904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004691
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase PRKX pan-specific antibody AB-NK292-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK292-1#Serine/threonine-protein kinase PRKX T201+T203 phosphosite-specific antibody AB-PK785#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK785#Serine/threonine-protein kinase PRKX (D340-F358, human) peptide - Powder PE-01BFC99T#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFC99T#Serine/threonine-protein kinase PRKX (V198-G206, human) pT201+pT203 phosphopeptide - Powder PE-04APD99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APD99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
Q
A
A
A
A
E
S
D
S
R
K
V
A
E
Site 2
T23
S
R
K
V
A
E
E
T
P
D
G
A
P
A
L
Site 3
S33
G
A
P
A
L
C
P
S
P
E
A
L
S
P
E
Site 4
S38
C
P
S
P
E
A
L
S
P
E
P
P
V
Y
S
Site 5
Y44
L
S
P
E
P
P
V
Y
S
L
Q
D
F
D
T
Site 6
S45
S
P
E
P
P
V
Y
S
L
Q
D
F
D
T
L
Site 7
T51
Y
S
L
Q
D
F
D
T
L
A
T
V
G
T
G
Site 8
S99
Q
H
V
H
N
E
K
S
V
L
K
E
V
S
H
Site 9
Y123
W
H
D
E
R
F
L
Y
M
L
M
E
Y
V
P
Site 10
S136
V
P
G
G
E
L
F
S
Y
L
R
N
R
G
R
Site 11
Y137
P
G
G
E
L
F
S
Y
L
R
N
R
G
R
F
Site 12
S145
L
R
N
R
G
R
F
S
S
T
T
G
L
F
Y
Site 13
S146
R
N
R
G
R
F
S
S
T
T
G
L
F
Y
S
Site 14
T148
R
G
R
F
S
S
T
T
G
L
F
Y
S
A
E
Site 15
T189
R
D
G
H
I
K
L
T
D
F
G
F
A
K
K
Site 16
T201
A
K
K
L
V
D
R
T
W
T
L
C
G
T
P
Serine/threonine-protein kinase PRKX T201+T203 phosphosite-specific antibody AB-PK785#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK785#Serine/threonine-protein kinase PRKX (V198-G206, human) pT201+pT203 phosphopeptide - Powder PE-04APD99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APD99
Site 17
T203
K
L
V
D
R
T
W
T
L
C
G
T
P
E
Y
Serine/threonine-protein kinase PRKX T201+T203 phosphosite-specific antibody AB-PK785#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK785#Serine/threonine-protein kinase PRKX (V198-G206, human) pT201+pT203 phosphopeptide - Powder PE-04APD99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APD99
Site 18
T207
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
Site 19
Y253
D
D
N
P
F
G
I
Y
Q
K
I
L
A
G
K
Site 20
T284
K
L
L
V
V
D
R
T
R
R
L
G
N
M
K
Site 21
T330
K
I
A
G
D
G
D
T
S
N
F
E
T
Y
P
Site 22
S331
I
A
G
D
G
D
T
S
N
F
E
T
Y
P
E
Site 23
Y336
D
T
S
N
F
E
T
Y
P
E
N
D
W
D
T
Site 24
T343
Y
P
E
N
D
W
D
T
A
A
P
V
P
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation