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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN7
Full Name:
H(+)/Cl(-) exchange transporter 7
Alias:
Chloride channel 7; CLC7; ClC-7; OPTA2
Type:
Channel, chloride; Membrane protein, integral
Mass (Da):
88679
Number AA:
805
UniProt ID:
P51798
International Prot ID:
IPI00940305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015297
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
N
V
S
K
K
V
S
W
S
G
R
D
R
D
Site 2
S11
V
S
K
K
V
S
W
S
G
R
D
R
D
D
E
Site 3
T27
A
A
P
L
L
R
R
T
A
R
P
G
G
G
T
Site 4
T34
T
A
R
P
G
G
G
T
P
L
L
N
G
A
G
Site 5
S48
G
P
G
A
A
R
Q
S
P
R
S
A
L
F
R
Site 6
S51
A
A
R
Q
S
P
R
S
A
L
F
R
V
G
H
Site 7
S60
L
F
R
V
G
H
M
S
S
V
E
L
D
D
E
Site 8
S61
F
R
V
G
H
M
S
S
V
E
L
D
D
E
L
Site 9
S91
P
H
N
E
K
L
L
S
L
K
Y
E
S
L
D
Site 10
Y94
E
K
L
L
S
L
K
Y
E
S
L
D
Y
D
N
Site 11
S96
L
L
S
L
K
Y
E
S
L
D
Y
D
N
S
E
Site 12
Y99
L
K
Y
E
S
L
D
Y
D
N
S
E
N
Q
L
Site 13
S102
E
S
L
D
Y
D
N
S
E
N
Q
L
F
L
E
Site 14
T117
E
E
R
R
I
N
H
T
A
F
R
T
V
E
I
Site 15
T121
I
N
H
T
A
F
R
T
V
E
I
K
R
W
V
Site 16
Y156
E
N
L
A
G
L
K
Y
R
V
I
K
G
N
I
Site 17
T167
K
G
N
I
D
K
F
T
E
K
G
G
L
S
F
Site 18
T226
P
H
V
V
R
L
K
T
L
V
I
K
V
S
G
Site 19
S232
K
T
L
V
I
K
V
S
G
V
I
L
S
V
V
Site 20
S237
K
V
S
G
V
I
L
S
V
V
G
G
L
A
V
Site 21
S266
A
G
I
S
Q
G
R
S
T
S
L
K
R
D
F
Site 22
T267
G
I
S
Q
G
R
S
T
S
L
K
R
D
F
K
Site 23
S268
I
S
Q
G
R
S
T
S
L
K
R
D
F
K
I
Site 24
Y278
R
D
F
K
I
F
E
Y
F
R
R
D
T
E
K
Site 25
T283
F
E
Y
F
R
R
D
T
E
K
R
D
F
V
S
Site 26
S317
F
S
L
E
E
G
A
S
F
W
N
Q
F
L
T
Site 27
S354
G
N
M
W
D
L
S
S
P
G
L
I
N
F
G
Site 28
Y370
F
D
S
E
K
M
A
Y
T
I
H
E
I
P
V
Site 29
Y406
L
T
M
F
R
I
R
Y
I
H
R
P
C
L
Q
Site 30
S445
C
Q
P
L
Q
G
G
S
M
S
Y
P
L
Q
L
Site 31
S473
F
F
N
T
P
E
K
S
V
V
S
L
F
H
D
Site 32
S476
T
P
E
K
S
V
V
S
L
F
H
D
P
P
G
Site 33
S484
L
F
H
D
P
P
G
S
Y
N
P
L
T
L
G
Site 34
T621
L
H
W
E
A
P
V
T
S
H
S
L
T
A
R
Site 35
S624
E
A
P
V
T
S
H
S
L
T
A
R
E
V
M
Site 36
T626
P
V
T
S
H
S
L
T
A
R
E
V
M
S
T
Site 37
T633
T
A
R
E
V
M
S
T
P
V
T
C
L
R
R
Site 38
T636
E
V
M
S
T
P
V
T
C
L
R
R
R
E
K
Site 39
T654
I
V
D
V
L
S
D
T
A
S
N
H
N
G
F
Site 40
S656
D
V
L
S
D
T
A
S
N
H
N
G
F
P
V
Site 41
T670
V
V
E
H
A
D
D
T
Q
P
A
R
L
Q
G
Site 42
S682
L
Q
G
L
I
L
R
S
Q
L
I
V
L
L
K
Site 43
Y715
L
K
D
F
R
D
A
Y
P
R
F
P
P
I
Q
Site 44
S723
P
R
F
P
P
I
Q
S
I
H
V
S
Q
D
E
Site 45
S727
P
I
Q
S
I
H
V
S
Q
D
E
R
E
C
T
Site 46
T734
S
Q
D
E
R
E
C
T
M
D
L
S
E
F
M
Site 47
S738
R
E
C
T
M
D
L
S
E
F
M
N
P
S
P
Site 48
S744
L
S
E
F
M
N
P
S
P
Y
T
V
P
Q
E
Site 49
Y746
E
F
M
N
P
S
P
Y
T
V
P
Q
E
A
S
Site 50
T747
F
M
N
P
S
P
Y
T
V
P
Q
E
A
S
L
Site 51
S801
K
R
G
L
E
E
L
S
L
A
Q
T
_
_
_
Site 52
T805
E
E
L
S
L
A
Q
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation