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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN6
Full Name:
Chloride transport protein 6
Alias:
Chloride channel protein 6
Type:
Mass (Da):
97217
Number AA:
869
UniProt ID:
P51797
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
C
C
C
G
E
R
E
T
R
T
P
E
E
L
T
Site 2
T25
C
G
E
R
E
T
R
T
P
E
E
L
T
I
L
Site 3
Y48
E
I
L
P
R
K
D
Y
E
S
L
D
Y
D
R
Site 4
S50
L
P
R
K
D
Y
E
S
L
D
Y
D
R
C
I
Site 5
Y53
K
D
Y
E
S
L
D
Y
D
R
C
I
N
D
P
Site 6
Y61
D
R
C
I
N
D
P
Y
L
E
V
L
E
T
M
Site 7
T67
P
Y
L
E
V
L
E
T
M
D
N
K
K
G
R
Site 8
Y76
D
N
K
K
G
R
R
Y
E
A
V
K
W
M
V
Site 9
S116
K
F
G
V
V
Q
T
S
V
E
E
C
S
Q
K
Site 10
S121
Q
T
S
V
E
E
C
S
Q
K
G
C
L
A
L
Site 11
S190
K
V
L
G
V
L
F
S
V
A
G
G
L
F
V
Site 12
S206
K
E
G
P
M
I
H
S
G
S
V
V
G
A
G
Site 13
S219
A
G
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
Site 14
S221
L
P
Q
F
Q
S
I
S
L
R
K
I
Q
F
N
Site 15
Y231
K
I
Q
F
N
F
P
Y
F
R
S
D
R
D
K
Site 16
S243
R
D
K
R
D
F
V
S
A
G
A
A
A
G
V
Site 17
S270
F
S
L
E
E
G
S
S
F
W
N
Q
G
L
T
Site 18
S302
R
S
G
I
Q
F
G
S
W
G
S
F
Q
L
P
Site 19
Y361
L
N
K
R
L
A
K
Y
R
M
R
N
V
H
P
Site 20
S403
L
G
E
C
R
Q
M
S
S
S
S
Q
I
G
N
Site 21
S404
G
E
C
R
Q
M
S
S
S
S
Q
I
G
N
D
Site 22
S405
E
C
R
Q
M
S
S
S
S
Q
I
G
N
D
S
Site 23
S406
C
R
Q
M
S
S
S
S
Q
I
G
N
D
S
F
Site 24
S412
S
S
Q
I
G
N
D
S
F
Q
L
Q
V
T
E
Site 25
T418
D
S
F
Q
L
Q
V
T
E
D
V
N
S
S
I
Site 26
S423
Q
V
T
E
D
V
N
S
S
I
K
T
F
F
C
Site 27
T427
D
V
N
S
S
I
K
T
F
F
C
P
N
D
T
Site 28
Y435
F
F
C
P
N
D
T
Y
N
D
M
A
T
L
F
Site 29
T459
Q
L
F
H
Q
D
G
T
F
S
P
V
T
L
A
Site 30
Y576
D
F
F
N
K
G
I
Y
D
I
H
V
G
L
R
Site 31
S602
E
M
D
K
L
R
A
S
D
I
M
E
P
N
L
Site 32
T610
D
I
M
E
P
N
L
T
Y
V
Y
P
H
T
R
Site 33
Y611
I
M
E
P
N
L
T
Y
V
Y
P
H
T
R
I
Site 34
Y613
E
P
N
L
T
Y
V
Y
P
H
T
R
I
Q
S
Site 35
T616
L
T
Y
V
Y
P
H
T
R
I
Q
S
L
V
S
Site 36
S620
Y
P
H
T
R
I
Q
S
L
V
S
I
L
R
T
Site 37
S662
N
N
I
K
F
K
K
S
S
I
L
T
R
A
G
Site 38
T666
F
K
K
S
S
I
L
T
R
A
G
E
Q
R
K
Site 39
S675
A
G
E
Q
R
K
R
S
Q
S
M
K
S
Y
P
Site 40
S677
E
Q
R
K
R
S
Q
S
M
K
S
Y
P
S
S
Site 41
S680
K
R
S
Q
S
M
K
S
Y
P
S
S
E
L
R
Site 42
Y681
R
S
Q
S
M
K
S
Y
P
S
S
E
L
R
N
Site 43
S684
S
M
K
S
Y
P
S
S
E
L
R
N
M
C
D
Site 44
S696
M
C
D
E
H
I
A
S
E
E
P
A
E
K
E
Site 45
Y714
Q
Q
M
L
E
R
R
Y
T
P
Y
P
N
L
Y
Site 46
T715
Q
M
L
E
R
R
Y
T
P
Y
P
N
L
Y
P
Site 47
Y717
L
E
R
R
Y
T
P
Y
P
N
L
Y
P
D
Q
Site 48
Y721
Y
T
P
Y
P
N
L
Y
P
D
Q
S
P
S
E
Site 49
S725
P
N
L
Y
P
D
Q
S
P
S
E
D
W
T
M
Site 50
S727
L
Y
P
D
Q
S
P
S
E
D
W
T
M
E
E
Site 51
T731
Q
S
P
S
E
D
W
T
M
E
E
R
F
R
P
Site 52
T740
E
E
R
F
R
P
L
T
F
H
G
L
I
L
R
Site 53
S761
L
V
R
G
V
C
Y
S
E
S
Q
S
S
A
S
Site 54
S763
R
G
V
C
Y
S
E
S
Q
S
S
A
S
Q
P
Site 55
S765
V
C
Y
S
E
S
Q
S
S
A
S
Q
P
R
L
Site 56
S766
C
Y
S
E
S
Q
S
S
A
S
Q
P
R
L
S
Site 57
S768
S
E
S
Q
S
S
A
S
Q
P
R
L
S
Y
A
Site 58
S773
S
A
S
Q
P
R
L
S
Y
A
E
M
A
E
D
Site 59
Y774
A
S
Q
P
R
L
S
Y
A
E
M
A
E
D
Y
Site 60
Y781
Y
A
E
M
A
E
D
Y
P
R
Y
P
D
I
H
Site 61
Y784
M
A
E
D
Y
P
R
Y
P
D
I
H
D
L
D
Site 62
T804
P
R
M
I
V
D
V
T
P
Y
M
N
P
S
P
Site 63
S810
V
T
P
Y
M
N
P
S
P
F
T
V
S
P
N
Site 64
T813
Y
M
N
P
S
P
F
T
V
S
P
N
T
H
V
Site 65
S815
N
P
S
P
F
T
V
S
P
N
T
H
V
S
Q
Site 66
T818
P
F
T
V
S
P
N
T
H
V
S
Q
V
F
N
Site 67
S821
V
S
P
N
T
H
V
S
Q
V
F
N
L
F
R
Site 68
Y855
I
T
R
H
N
L
T
Y
E
F
L
Q
A
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation