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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN5
Full Name:
H(+)/Cl(-) exchange transporter 5
Alias:
Chloride channel 5; Chloride channel protein 5; Chloride transporter ClC-5; CLC5; ClC-5; CLCK2; Dent disease; DENTS; NPHL2; XLRH; XRN
Type:
Mass (Da):
83147
Number AA:
746
UniProt ID:
P51795
International Prot ID:
IPI00294056
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0045177
GO:0005768
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015297
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0007588
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
P
I
P
G
V
G
T
Y
D
D
F
N
T
I
D
Site 2
S27
I
D
W
V
R
E
K
S
R
D
R
D
R
H
R
Site 3
T37
R
D
R
H
R
E
I
T
N
K
S
K
E
S
T
Site 4
S40
H
R
E
I
T
N
K
S
K
E
S
T
W
A
L
Site 5
T44
T
N
K
S
K
E
S
T
W
A
L
I
H
S
V
Site 6
T109
C
W
N
S
E
H
V
T
F
E
E
R
D
K
C
Site 7
Y232
L
C
H
C
F
N
K
Y
R
K
N
E
A
K
R
Site 8
Y272
S
L
E
E
V
S
Y
Y
F
P
L
K
T
L
W
Site 9
T349
A
W
C
R
K
R
K
T
T
Q
L
G
K
Y
P
Site 10
T350
W
C
R
K
R
K
T
T
Q
L
G
K
Y
P
V
Site 11
Y376
I
L
A
F
P
N
E
Y
T
R
M
S
T
S
E
Site 12
S380
P
N
E
Y
T
R
M
S
T
S
E
L
I
S
E
Site 13
T381
N
E
Y
T
R
M
S
T
S
E
L
I
S
E
L
Site 14
S382
E
Y
T
R
M
S
T
S
E
L
I
S
E
L
F
Site 15
S386
M
S
T
S
E
L
I
S
E
L
F
N
D
C
G
Site 16
S398
D
C
G
L
L
D
S
S
K
L
C
D
Y
E
N
Site 17
Y403
D
S
S
K
L
C
D
Y
E
N
R
F
N
T
S
Site 18
T409
D
Y
E
N
R
F
N
T
S
K
G
G
E
L
P
Site 19
Y425
R
P
A
G
V
G
V
Y
S
A
M
W
Q
L
A
Site 20
Y478
V
G
M
E
Q
L
A
Y
Y
H
Q
E
W
T
V
Site 21
Y558
A
L
G
R
E
G
I
Y
D
A
H
I
R
L
N
Site 22
Y567
A
H
I
R
L
N
G
Y
P
F
L
E
A
K
E
Site 23
T580
K
E
E
F
A
H
K
T
L
A
M
D
V
M
K
Site 24
T596
R
R
N
D
P
L
L
T
V
L
T
Q
D
S
M
Site 25
T610
M
T
V
E
D
V
E
T
I
I
S
E
T
T
Y
Site 26
S613
E
D
V
E
T
I
I
S
E
T
T
Y
S
G
F
Site 27
S643
L
R
R
D
L
I
I
S
I
E
N
A
R
K
K
Site 28
S656
K
K
Q
D
G
V
V
S
T
S
I
I
Y
F
T
Site 29
T663
S
T
S
I
I
Y
F
T
E
H
S
P
P
L
P
Site 30
S666
I
I
Y
F
T
E
H
S
P
P
L
P
P
Y
T
Site 31
Y672
H
S
P
P
L
P
P
Y
T
P
P
T
L
K
L
Site 32
T673
S
P
P
L
P
P
Y
T
P
P
T
L
K
L
R
Site 33
T676
L
P
P
Y
T
P
P
T
L
K
L
R
N
I
L
Site 34
T724
G
R
L
L
G
I
I
T
K
K
D
V
L
K
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation