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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv7.1
Full Name:
Potassium voltage-gated channel subfamily KQT member 1
Alias:
Jervell and Lange-Nielsen syndrome 1; JLNS1; KCNA8; KCNA9; KCNQ1; KQT-like 1; KvLQT1; LQT; potassium voltage-gated channel, KQT-like subfamily, member 1
Type:
Channel protein, potassium
Mass (Da):
74699
Number AA:
676
UniProt ID:
P51787
International Prot ID:
IPI00020502
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005251
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0051899
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Potassium voltage-gated channel subfamily KQT member 1 pan-specific antibody AB-NN274-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN274-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
A
S
S
P
P
R
A
E
R
K
Site 2
S27
L
P
G
A
R
R
G
S
A
G
L
A
K
K
C
Site 3
S66
P
G
P
A
P
P
A
S
P
A
A
P
A
A
P
Site 4
S86
L
G
P
R
P
P
V
S
L
D
P
R
V
S
I
Site 5
S92
V
S
L
D
P
R
V
S
I
Y
S
T
R
R
P
Site 6
Y94
L
D
P
R
V
S
I
Y
S
T
R
R
P
V
L
Site 7
S95
D
P
R
V
S
I
Y
S
T
R
R
P
V
L
A
Site 8
T96
P
R
V
S
I
Y
S
T
R
R
P
V
L
A
R
Site 9
Y111
T
H
V
Q
G
R
V
Y
N
F
L
E
R
P
T
Site 10
S177
E
Y
V
V
R
L
W
S
A
G
C
R
S
K
Y
Site 11
Y184
S
A
G
C
R
S
K
Y
V
G
L
W
G
R
L
Site 12
T247
H
V
D
R
Q
G
G
T
W
R
L
L
G
S
V
Site 13
S291
E
K
D
A
V
N
E
S
G
R
V
E
F
G
S
Site 14
S298
S
G
R
V
E
F
G
S
Y
A
D
A
L
W
W
Site 15
Y299
G
R
V
E
F
G
S
Y
A
D
A
L
W
W
G
Site 16
T322
Y
G
D
K
V
P
Q
T
W
V
G
K
T
I
A
Site 17
S373
R
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
Site 18
Y382
I
Q
T
A
W
R
C
Y
A
A
E
N
P
D
S
Site 19
S390
A
A
E
N
P
D
S
S
T
W
K
I
Y
I
R
Site 20
Y395
D
S
S
T
W
K
I
Y
I
R
K
A
P
R
S
Site 21
S402
Y
I
R
K
A
P
R
S
H
T
L
L
S
P
S
Site 22
T404
R
K
A
P
R
S
H
T
L
L
S
P
S
P
K
Site 23
S407
P
R
S
H
T
L
L
S
P
S
P
K
P
K
K
Site 24
S409
S
H
T
L
L
S
P
S
P
K
P
K
K
S
V
Site 25
S415
P
S
P
K
P
K
K
S
V
V
V
K
K
K
K
Site 26
T432
L
D
K
D
N
G
V
T
P
G
E
K
M
L
T
Site 27
T439
T
P
G
E
K
M
L
T
V
P
H
I
T
C
D
Site 28
S457
E
R
R
L
D
H
F
S
V
D
G
Y
D
S
S
Site 29
Y461
D
H
F
S
V
D
G
Y
D
S
S
V
R
K
S
Site 30
S463
F
S
V
D
G
Y
D
S
S
V
R
K
S
P
T
Site 31
S464
S
V
D
G
Y
D
S
S
V
R
K
S
P
T
L
Site 32
S468
Y
D
S
S
V
R
K
S
P
T
L
L
E
V
S
Site 33
T470
S
S
V
R
K
S
P
T
L
L
E
V
S
M
P
Site 34
S475
S
P
T
L
L
E
V
S
M
P
H
F
M
R
T
Site 35
S484
P
H
F
M
R
T
N
S
F
A
E
D
L
D
L
Site 36
T501
E
T
L
L
T
P
I
T
H
I
S
Q
L
R
E
Site 37
S504
L
T
P
I
T
H
I
S
Q
L
R
E
H
H
R
Site 38
T513
L
R
E
H
H
R
A
T
I
K
V
I
R
R
M
Site 39
Y522
K
V
I
R
R
M
Q
Y
F
V
A
K
K
K
F
Site 40
Y536
F
Q
Q
A
R
K
P
Y
D
V
R
D
V
I
E
Site 41
S546
R
D
V
I
E
Q
Y
S
Q
G
H
L
N
L
M
Site 42
S566
L
Q
R
R
L
D
Q
S
I
G
K
P
S
L
F
Site 43
S571
D
Q
S
I
G
K
P
S
L
F
I
S
V
S
E
Site 44
S575
G
K
P
S
L
F
I
S
V
S
E
K
S
K
D
Site 45
S577
P
S
L
F
I
S
V
S
E
K
S
K
D
R
G
Site 46
S580
F
I
S
V
S
E
K
S
K
D
R
G
S
N
T
Site 47
S585
E
K
S
K
D
R
G
S
N
T
I
G
A
R
L
Site 48
T587
S
K
D
R
G
S
N
T
I
G
A
R
L
N
R
Site 49
T600
N
R
V
E
D
K
V
T
Q
L
D
Q
R
L
A
Site 50
S618
D
M
L
H
Q
L
L
S
L
H
G
G
S
T
P
Site 51
S623
L
L
S
L
H
G
G
S
T
P
G
S
G
G
P
Site 52
T624
L
S
L
H
G
G
S
T
P
G
S
G
G
P
P
Site 53
S627
H
G
G
S
T
P
G
S
G
G
P
P
R
E
G
Site 54
T639
R
E
G
G
A
H
I
T
Q
P
C
G
S
G
G
Site 55
S647
Q
P
C
G
S
G
G
S
V
D
P
E
L
F
L
Site 56
S656
D
P
E
L
F
L
P
S
N
T
L
P
T
Y
E
Site 57
Y662
P
S
N
T
L
P
T
Y
E
Q
L
T
V
P
R
Site 58
T666
L
P
T
Y
E
Q
L
T
V
P
R
R
G
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation