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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSD17B4
Full Name:
Peroxisomal multifunctional enzyme type 2
Alias:
17beta-estradiol dehydrogenase type IV; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; Beta-hydroxyacyl dehydrogenase; Beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; DHB4; EDH17B4; Hydroxysteroid (17-beta) dehydrogenase 4; MFE-2; Peroxisomal multifunctional protein 2; SDR8C1; Short chain dehydrogenase/reductase family 8C, member 1
Type:
EC 4.2.1.107; Transporter; Lipid Metabolism - primary bile acid biosynthesis; Cell development/differentiation; Lyase; Oxidoreductase; EC 1.1.1.35; Mitochondrial
Mass (Da):
79686
Number AA:
736
UniProt ID:
P51659
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005782
Uniprot
OncoNet
Molecular Function:
GO:0003857
GO:0033989
GO:0004303
PhosphoSite+
KinaseNET
Biological Process:
GO:0033540
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
G
S
P
L
R
F
D
G
R
Site 2
T15
D
G
R
V
V
L
V
T
G
A
G
A
G
L
G
Site 3
Y73
G
G
K
A
V
A
N
Y
D
S
V
E
E
G
E
Site 4
S75
K
A
V
A
N
Y
D
S
V
E
E
G
E
K
V
Site 5
T85
E
G
E
K
V
V
K
T
A
L
D
A
F
G
R
Site 6
S107
A
G
I
L
R
D
R
S
F
A
R
I
S
D
E
Site 7
S112
D
R
S
F
A
R
I
S
D
E
D
W
D
I
I
Site 8
S127
H
R
V
H
L
R
G
S
F
Q
V
T
R
A
A
Site 9
Y143
E
H
M
K
K
Q
K
Y
G
R
I
I
M
T
S
Site 10
T149
K
Y
G
R
I
I
M
T
S
S
A
S
G
I
Y
Site 11
S150
Y
G
R
I
I
M
T
S
S
A
S
G
I
Y
G
Site 12
S151
G
R
I
I
M
T
S
S
A
S
G
I
Y
G
N
Site 13
Y156
T
S
S
A
S
G
I
Y
G
N
F
G
Q
A
N
Site 14
S185
L
A
I
E
G
R
K
S
N
I
H
C
N
T
I
Site 15
T201
P
N
A
G
S
R
M
T
Q
T
V
M
P
E
D
Site 16
T203
A
G
S
R
M
T
Q
T
V
M
P
E
D
L
V
Site 17
T252
G
K
L
R
W
E
R
T
L
G
A
I
V
R
Q
Site 18
T265
R
Q
K
N
H
P
M
T
P
E
A
V
K
A
N
Site 19
S283
I
C
D
F
E
N
A
S
K
P
Q
S
I
Q
E
Site 20
S287
E
N
A
S
K
P
Q
S
I
Q
E
S
T
G
S
Site 21
S291
K
P
Q
S
I
Q
E
S
T
G
S
I
I
E
V
Site 22
T292
P
Q
S
I
Q
E
S
T
G
S
I
I
E
V
L
Site 23
S294
S
I
Q
E
S
T
G
S
I
I
E
V
L
S
K
Site 24
S304
E
V
L
S
K
I
D
S
E
G
G
V
S
A
N
Site 25
S309
I
D
S
E
G
G
V
S
A
N
H
T
S
R
A
Site 26
T313
G
G
V
S
A
N
H
T
S
R
A
T
S
T
A
Site 27
S314
G
V
S
A
N
H
T
S
R
A
T
S
T
A
T
Site 28
T317
A
N
H
T
S
R
A
T
S
T
A
T
S
G
F
Site 29
S318
N
H
T
S
R
A
T
S
T
A
T
S
G
F
A
Site 30
T319
H
T
S
R
A
T
S
T
A
T
S
G
F
A
G
Site 31
S336
G
Q
K
L
P
P
F
S
Y
A
Y
T
E
L
E
Site 32
T340
P
P
F
S
Y
A
Y
T
E
L
E
A
I
M
Y
Site 33
Y365
P
K
D
L
K
F
I
Y
E
G
S
S
D
F
S
Site 34
S369
K
F
I
Y
E
G
S
S
D
F
S
C
L
P
T
Site 35
S372
Y
E
G
S
S
D
F
S
C
L
P
T
F
G
V
Site 36
Y410
K
V
L
H
G
E
Q
Y
L
E
L
Y
K
P
L
Site 37
Y414
G
E
Q
Y
L
E
L
Y
K
P
L
P
R
A
G
Site 38
Y446
V
V
I
I
M
D
V
Y
S
Y
S
E
K
E
L
Site 39
Y448
I
I
M
D
V
Y
S
Y
S
E
K
E
L
I
C
Site 40
S475
G
F
G
G
K
R
T
S
D
K
V
K
V
A
V
Site 41
T494
R
P
P
D
A
V
L
T
D
T
T
S
L
N
Q
Site 42
T496
P
D
A
V
L
T
D
T
T
S
L
N
Q
A
A
Site 43
Y505
S
L
N
Q
A
A
L
Y
R
L
S
G
D
W
N
Site 44
S508
Q
A
A
L
Y
R
L
S
G
D
W
N
P
L
H
Site 45
S522
H
I
D
P
N
F
A
S
L
A
G
F
D
K
P
Site 46
Y568
A
R
F
A
K
P
V
Y
P
G
Q
T
L
Q
T
Site 47
T588
G
N
R
I
H
F
Q
T
K
V
Q
E
T
G
D
Site 48
T608
A
Y
V
D
L
A
P
T
S
G
T
S
A
K
T
Site 49
S609
Y
V
D
L
A
P
T
S
G
T
S
A
K
T
P
Site 50
T615
T
S
G
T
S
A
K
T
P
S
E
G
G
K
L
Site 51
S617
G
T
S
A
K
T
P
S
E
G
G
K
L
Q
S
Site 52
S624
S
E
G
G
K
L
Q
S
T
F
V
F
E
E
I
Site 53
T625
E
G
G
K
L
Q
S
T
F
V
F
E
E
I
G
Site 54
S670
K
W
T
I
D
L
K
S
G
S
G
K
V
Y
Q
Site 55
Y676
K
S
G
S
G
K
V
Y
Q
G
P
A
K
G
A
Site 56
S711
D
P
Q
K
A
F
F
S
G
R
L
K
A
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation