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Updated November 2019
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Protein Info
Short Name:
BRCA2
Full Name:
Breast cancer type 2 susceptibility protein
Alias:
BRCA1/BRCA2-containing complex, subunit 2; BRCC2; breast cancer 2, early onset; FACD; FAD; FAD1; familial breast/ovarian cancer gene 2; FANCD; FANCD1
Type:
Nuclear receptor co-regulator; DNA repair
Mass (Da):
384225
Number AA:
3418
UniProt ID:
P51587
International Prot ID:
IPI00412408
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033593
GO:0005813
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0043015
GO:0003697
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0051298
GO:0033205
GO:0033600
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
I
G
S
K
E
R
P
T
F
F
E
I
F
K
T
Site 2
S28
K
A
D
L
G
P
I
S
L
N
W
F
E
E
L
Site 3
S36
L
N
W
F
E
E
L
S
S
E
A
P
P
Y
N
Site 4
S37
N
W
F
E
E
L
S
S
E
A
P
P
Y
N
S
Site 5
Y42
L
S
S
E
A
P
P
Y
N
S
E
P
A
E
E
Site 6
S44
S
E
A
P
P
Y
N
S
E
P
A
E
E
S
E
Site 7
S50
N
S
E
P
A
E
E
S
E
H
K
N
N
N
Y
Site 8
Y57
S
E
H
K
N
N
N
Y
E
P
N
L
F
K
T
Site 9
T64
Y
E
P
N
L
F
K
T
P
Q
R
K
P
S
Y
Site 10
S70
K
T
P
Q
R
K
P
S
Y
N
Q
L
A
S
T
Site 11
Y71
T
P
Q
R
K
P
S
Y
N
Q
L
A
S
T
P
Site 12
S76
P
S
Y
N
Q
L
A
S
T
P
I
I
F
K
E
Site 13
T77
S
Y
N
Q
L
A
S
T
P
I
I
F
K
E
Q
Site 14
T87
I
F
K
E
Q
G
L
T
L
P
L
Y
Q
S
P
Site 15
Y91
Q
G
L
T
L
P
L
Y
Q
S
P
V
K
E
L
Site 16
S93
L
T
L
P
L
Y
Q
S
P
V
K
E
L
D
K
Site 17
S112
L
G
R
N
V
P
N
S
R
H
K
S
L
R
T
Site 18
S116
V
P
N
S
R
H
K
S
L
R
T
V
K
T
K
Site 19
T119
S
R
H
K
S
L
R
T
V
K
T
K
M
D
Q
Site 20
T122
K
S
L
R
T
V
K
T
K
M
D
Q
A
D
D
Site 21
S131
M
D
Q
A
D
D
V
S
C
P
L
L
N
S
C
Site 22
T152
V
L
Q
C
T
H
V
T
P
Q
R
D
K
S
V
Site 23
S158
V
T
P
Q
R
D
K
S
V
V
C
G
S
L
F
Site 24
S163
D
K
S
V
V
C
G
S
L
F
H
T
P
K
F
Site 25
T167
V
C
G
S
L
F
H
T
P
K
F
V
K
G
R
Site 26
T176
K
F
V
K
G
R
Q
T
P
K
H
I
S
E
S
Site 27
S193
A
E
V
D
P
D
M
S
W
S
S
S
L
A
T
Site 28
S195
V
D
P
D
M
S
W
S
S
S
L
A
T
P
P
Site 29
S196
D
P
D
M
S
W
S
S
S
L
A
T
P
P
T
Site 30
S197
P
D
M
S
W
S
S
S
L
A
T
P
P
T
L
Site 31
T200
S
W
S
S
S
L
A
T
P
P
T
L
S
S
T
Site 32
T203
S
S
L
A
T
P
P
T
L
S
S
T
V
L
I
Site 33
S205
L
A
T
P
P
T
L
S
S
T
V
L
I
V
R
Site 34
S206
A
T
P
P
T
L
S
S
T
V
L
I
V
R
N
Site 35
T207
T
P
P
T
L
S
S
T
V
L
I
V
R
N
E
Site 36
S217
I
V
R
N
E
E
A
S
E
T
V
F
P
H
D
Site 37
T219
R
N
E
E
A
S
E
T
V
F
P
H
D
T
T
Site 38
T225
E
T
V
F
P
H
D
T
T
A
N
V
K
S
Y
Site 39
T226
T
V
F
P
H
D
T
T
A
N
V
K
S
Y
F
Site 40
Y232
T
T
A
N
V
K
S
Y
F
S
N
H
D
E
S
Site 41
S234
A
N
V
K
S
Y
F
S
N
H
D
E
S
L
K
Site 42
S239
Y
F
S
N
H
D
E
S
L
K
K
N
D
R
F
Site 43
S249
K
N
D
R
F
I
A
S
V
T
D
S
E
N
T
Site 44
S253
F
I
A
S
V
T
D
S
E
N
T
N
Q
R
E
Site 45
T269
A
S
H
G
F
G
K
T
S
G
N
S
F
K
V
Site 46
S270
S
H
G
F
G
K
T
S
G
N
S
F
K
V
N
Site 47
S273
F
G
K
T
S
G
N
S
F
K
V
N
S
C
K
Site 48
Y296
N
V
L
E
D
E
V
Y
E
T
V
V
D
T
S
Site 49
T298
L
E
D
E
V
Y
E
T
V
V
D
T
S
E
E
Site 50
S303
Y
E
T
V
V
D
T
S
E
E
D
S
F
S
L
Site 51
S307
V
D
T
S
E
E
D
S
F
S
L
C
F
S
K
Site 52
S309
T
S
E
E
D
S
F
S
L
C
F
S
K
C
R
Site 53
S313
D
S
F
S
L
C
F
S
K
C
R
T
K
N
L
Site 54
T317
L
C
F
S
K
C
R
T
K
N
L
Q
K
V
R
Site 55
S326
N
L
Q
K
V
R
T
S
K
T
R
K
K
I
F
Site 56
T328
Q
K
V
R
T
S
K
T
R
K
K
I
F
H
E
Site 57
S344
N
A
D
E
C
E
K
S
K
N
Q
V
K
E
K
Site 58
Y352
K
N
Q
V
K
E
K
Y
S
F
V
S
E
V
E
Site 59
S353
N
Q
V
K
E
K
Y
S
F
V
S
E
V
E
P
Site 60
T363
S
E
V
E
P
N
D
T
D
P
L
D
S
N
V
Site 61
S368
N
D
T
D
P
L
D
S
N
V
A
H
Q
K
P
Site 62
S378
A
H
Q
K
P
F
E
S
G
S
D
K
I
S
K
Site 63
S380
Q
K
P
F
E
S
G
S
D
K
I
S
K
E
V
Site 64
S384
E
S
G
S
D
K
I
S
K
E
V
V
P
S
L
Site 65
S390
I
S
K
E
V
V
P
S
L
A
C
E
W
S
Q
Site 66
S401
E
W
S
Q
L
T
L
S
G
L
N
G
A
Q
M
Site 67
S417
K
I
P
L
L
H
I
S
S
C
D
Q
N
I
S
Site 68
S418
I
P
L
L
H
I
S
S
C
D
Q
N
I
S
E
Site 69
S424
S
S
C
D
Q
N
I
S
E
K
D
L
L
D
T
Site 70
T431
S
E
K
D
L
L
D
T
E
N
K
R
K
K
D
Site 71
T441
K
R
K
K
D
F
L
T
S
E
N
S
L
P
R
Site 72
S445
D
F
L
T
S
E
N
S
L
P
R
I
S
S
L
Site 73
S450
E
N
S
L
P
R
I
S
S
L
P
K
S
E
K
Site 74
S451
N
S
L
P
R
I
S
S
L
P
K
S
E
K
P
Site 75
S455
R
I
S
S
L
P
K
S
E
K
P
L
N
E
E
Site 76
T463
E
K
P
L
N
E
E
T
V
V
N
K
R
D
E
Site 77
S492
K
Q
A
I
S
G
T
S
P
V
A
S
S
F
Q
Site 78
S496
S
G
T
S
P
V
A
S
S
F
Q
G
I
K
K
Site 79
S497
G
T
S
P
V
A
S
S
F
Q
G
I
K
K
S
Site 80
S504
S
F
Q
G
I
K
K
S
I
F
R
I
R
E
S
Site 81
S511
S
I
F
R
I
R
E
S
P
K
E
T
F
N
A
Site 82
T515
I
R
E
S
P
K
E
T
F
N
A
S
F
S
G
Site 83
S519
P
K
E
T
F
N
A
S
F
S
G
H
M
T
D
Site 84
T525
A
S
F
S
G
H
M
T
D
P
N
F
K
K
E
Site 85
S536
F
K
K
E
T
E
A
S
E
S
G
L
E
I
H
Site 86
S538
K
E
T
E
A
S
E
S
G
L
E
I
H
T
V
Site 87
T544
E
S
G
L
E
I
H
T
V
C
S
Q
K
E
D
Site 88
S547
L
E
I
H
T
V
C
S
Q
K
E
D
S
L
C
Site 89
S552
V
C
S
Q
K
E
D
S
L
C
P
N
L
I
D
Site 90
S562
P
N
L
I
D
N
G
S
W
P
A
T
T
T
Q
Site 91
T566
D
N
G
S
W
P
A
T
T
T
Q
N
S
V
A
Site 92
T567
N
G
S
W
P
A
T
T
T
Q
N
S
V
A
L
Site 93
S581
L
K
N
A
G
L
I
S
T
L
K
K
K
T
N
Site 94
S599
Y
A
I
H
D
E
T
S
Y
K
G
K
K
I
P
Site 95
S611
K
I
P
K
D
Q
K
S
E
L
I
N
C
S
A
Site 96
T630
N
A
F
E
A
P
L
T
F
A
N
A
D
S
G
Site 97
S641
A
D
S
G
L
L
H
S
S
V
K
R
S
C
S
Site 98
S642
D
S
G
L
L
H
S
S
V
K
R
S
C
S
Q
Site 99
S646
L
H
S
S
V
K
R
S
C
S
Q
N
D
S
E
Site 100
S648
S
S
V
K
R
S
C
S
Q
N
D
S
E
E
P
Site 101
S652
R
S
C
S
Q
N
D
S
E
E
P
T
L
S
L
Site 102
T656
Q
N
D
S
E
E
P
T
L
S
L
T
S
S
F
Site 103
S658
D
S
E
E
P
T
L
S
L
T
S
S
F
G
T
Site 104
T665
S
L
T
S
S
F
G
T
I
L
R
K
C
S
R
Site 105
S671
G
T
I
L
R
K
C
S
R
N
E
T
C
S
N
Site 106
T675
R
K
C
S
R
N
E
T
C
S
N
N
T
V
I
Site 107
T680
N
E
T
C
S
N
N
T
V
I
S
Q
D
L
D
Site 108
S683
C
S
N
N
T
V
I
S
Q
D
L
D
Y
K
E
Site 109
Y688
V
I
S
Q
D
L
D
Y
K
E
A
K
C
N
K
Site 110
T703
E
K
L
Q
L
F
I
T
P
E
A
D
S
L
S
Site 111
S708
F
I
T
P
E
A
D
S
L
S
C
L
Q
E
G
Site 112
S710
T
P
E
A
D
S
L
S
C
L
Q
E
G
Q
C
Site 113
S723
Q
C
E
N
D
P
K
S
K
K
V
S
D
I
K
Site 114
S727
D
P
K
S
K
K
V
S
D
I
K
E
E
V
L
Site 115
S749
Q
H
S
K
V
E
Y
S
D
T
D
F
Q
S
Q
Site 116
T751
S
K
V
E
Y
S
D
T
D
F
Q
S
Q
K
S
Site 117
S755
Y
S
D
T
D
F
Q
S
Q
K
S
L
L
Y
D
Site 118
S758
T
D
F
Q
S
Q
K
S
L
L
Y
D
H
E
N
Site 119
T768
Y
D
H
E
N
A
S
T
L
I
L
T
P
T
S
Site 120
S780
P
T
S
K
D
V
L
S
N
L
V
M
I
S
R
Site 121
S786
L
S
N
L
V
M
I
S
R
G
K
E
S
Y
K
Site 122
S795
G
K
E
S
Y
K
M
S
D
K
L
K
G
N
N
Site 123
Y803
D
K
L
K
G
N
N
Y
E
S
D
V
E
L
T
Site 124
S805
L
K
G
N
N
Y
E
S
D
V
E
L
T
K
N
Site 125
Y839
E
L
L
P
P
E
K
Y
M
R
V
A
S
P
S
Site 126
S844
E
K
Y
M
R
V
A
S
P
S
R
K
V
Q
F
Site 127
S846
Y
M
R
V
A
S
P
S
R
K
V
Q
F
N
Q
Site 128
S869
K
N
Q
E
E
T
T
S
I
S
K
I
T
V
N
Site 129
T874
T
T
S
I
S
K
I
T
V
N
P
D
S
E
E
Site 130
S879
K
I
T
V
N
P
D
S
E
E
L
F
S
D
N
Site 131
S884
P
D
S
E
E
L
F
S
D
N
E
N
N
F
V
Site 132
T912
N
T
K
E
L
H
E
T
D
L
T
C
V
N
E
Site 133
T915
E
L
H
E
T
D
L
T
C
V
N
E
P
I
F
Site 134
Y930
K
N
S
T
M
V
L
Y
G
D
T
G
D
K
Q
Site 135
Y949
S
I
K
K
D
L
V
Y
V
L
A
E
E
N
K
Site 136
S958
L
A
E
E
N
K
N
S
V
K
Q
H
I
K
M
Site 137
S973
T
L
G
Q
D
L
K
S
D
I
S
L
N
I
D
Site 138
S976
Q
D
L
K
S
D
I
S
L
N
I
D
K
I
P
Site 139
Y989
I
P
E
K
N
N
D
Y
M
N
K
W
A
G
L
Site 140
S1004
L
G
P
I
S
N
H
S
F
G
G
S
F
R
T
Site 141
S1008
S
N
H
S
F
G
G
S
F
R
T
A
S
N
K
Site 142
S1013
G
G
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Site 294
S2156
I
K
V
S
P
Y
L
S
Q
F
Q
Q
D
K
Q
Site 295
S2186
V
L
G
K
E
Q
A
S
P
K
N
V
K
M
E
Site 296
T2197
V
K
M
E
I
G
K
T
E
T
F
S
D
V
P
Site 297
T2199
M
E
I
G
K
T
E
T
F
S
D
V
P
V
K
Site 298
S2201
I
G
K
T
E
T
F
S
D
V
P
V
K
T
N
Site 299
S2213
K
T
N
I
E
V
C
S
T
Y
S
K
D
S
E
Site 300
T2214
T
N
I
E
V
C
S
T
Y
S
K
D
S
E
N
Site 301
Y2215
N
I
E
V
C
S
T
Y
S
K
D
S
E
N
Y
Site 302
S2219
C
S
T
Y
S
K
D
S
E
N
Y
F
E
T
E
Site 303
T2241
F
M
E
D
D
E
L
T
D
S
K
L
P
S
H
Site 304
S2243
E
D
D
E
L
T
D
S
K
L
P
S
H
A
T
Site 305
S2247
L
T
D
S
K
L
P
S
H
A
T
H
S
L
F
Site 306
T2250
S
K
L
P
S
H
A
T
H
S
L
F
T
C
P
Site 307
S2252
L
P
S
H
A
T
H
S
L
F
T
C
P
E
N
Site 308
S2265
E
N
E
E
M
V
L
S
N
S
R
I
G
K
R
Site 309
S2303
I
I
E
N
Q
E
K
S
L
K
A
S
K
S
T
Site 310
S2307
Q
E
K
S
L
K
A
S
K
S
T
P
D
G
T
Site 311
S2309
K
S
L
K
A
S
K
S
T
P
D
G
T
I
K
Site 312
T2310
S
L
K
A
S
K
S
T
P
D
G
T
I
K
D
Site 313
T2314
S
K
S
T
P
D
G
T
I
K
D
R
R
L
F
Site 314
T2338
T
C
V
P
F
R
T
T
K
E
R
Q
E
I
Q
Site 315
S2358
A
P
G
Q
E
F
L
S
K
S
H
L
Y
E
H
Site 316
S2360
G
Q
E
F
L
S
K
S
H
L
Y
E
H
L
T
Site 317
Y2363
F
L
S
K
S
H
L
Y
E
H
L
T
L
E
K
Site 318
T2367
S
H
L
Y
E
H
L
T
L
E
K
S
S
S
N
Site 319
S2371
E
H
L
T
L
E
K
S
S
S
N
L
A
V
S
Site 320
S2373
L
T
L
E
K
S
S
S
N
L
A
V
S
G
H
Site 321
S2378
S
S
S
N
L
A
V
S
G
H
P
F
Y
Q
V
Site 322
Y2383
A
V
S
G
H
P
F
Y
Q
V
S
A
T
R
N
Site 323
T2399
K
M
R
H
L
I
T
T
G
R
P
T
K
V
F
Site 324
S2414
V
P
P
F
K
T
K
S
H
F
H
R
V
E
Q
Site 325
S2442
Q
N
I
D
G
H
G
S
D
D
S
K
N
K
I
Site 326
S2445
D
G
H
G
S
D
D
S
K
N
K
I
N
D
N
Site 327
T2469
S
N
Q
A
A
A
V
T
F
T
K
C
E
E
E
Site 328
S2483
E
P
L
D
L
I
T
S
L
Q
N
A
R
D
I
Site 329
S2509
R
V
F
P
Q
P
G
S
L
Y
L
A
K
T
S
Site 330
Y2511
F
P
Q
P
G
S
L
Y
L
A
K
T
S
T
L
Site 331
T2515
G
S
L
Y
L
A
K
T
S
T
L
P
R
I
S
Site 332
S2533
A
V
G
G
Q
V
P
S
A
C
S
H
K
Q
L
Site 333
Y2541
A
C
S
H
K
Q
L
Y
T
Y
G
V
S
K
H
Site 334
T2542
C
S
H
K
Q
L
Y
T
Y
G
V
S
K
H
C
Site 335
Y2543
S
H
K
Q
L
Y
T
Y
G
V
S
K
H
C
I
Site 336
S2559
I
N
S
K
N
A
E
S
F
Q
F
H
T
E
D
Site 337
Y2567
F
Q
F
H
T
E
D
Y
F
G
K
E
S
L
W
Site 338
S2572
E
D
Y
F
G
K
E
S
L
W
T
G
K
G
I
Site 339
T2575
F
G
K
E
S
L
W
T
G
K
G
I
Q
L
A
Site 340
S2590
D
G
G
W
L
I
P
S
N
D
G
K
A
G
K
Site 341
T2607
F
Y
R
A
L
C
D
T
P
G
V
D
P
K
L
Site 342
S2648
E
F
A
N
R
C
L
S
P
E
R
V
L
L
Q
Site 343
Y2658
R
V
L
L
Q
L
K
Y
R
Y
D
T
E
I
D
Site 344
T2662
Q
L
K
Y
R
Y
D
T
E
I
D
R
S
R
R
Site 345
S2667
Y
D
T
E
I
D
R
S
R
R
S
A
I
K
K
Site 346
S2670
E
I
D
R
S
R
R
S
A
I
K
K
I
M
E
Site 347
T2681
K
I
M
E
R
D
D
T
A
A
K
T
L
V
L
Site 348
T2685
R
D
D
T
A
A
K
T
L
V
L
C
V
S
D
Site 349
S2701
I
S
L
S
A
N
I
S
E
T
S
S
N
K
T
Site 350
T2703
L
S
A
N
I
S
E
T
S
S
N
K
T
S
S
Site 351
S2704
S
A
N
I
S
E
T
S
S
N
K
T
S
S
A
Site 352
S2705
A
N
I
S
E
T
S
S
N
K
T
S
S
A
D
Site 353
T2708
S
E
T
S
S
N
K
T
S
S
A
D
T
Q
K
Site 354
S2709
E
T
S
S
N
K
T
S
S
A
D
T
Q
K
V
Site 355
T2713
N
K
T
S
S
A
D
T
Q
K
V
A
I
I
E
Site 356
Y2726
I
E
L
T
D
G
W
Y
A
V
K
A
Q
L
D
Site 357
T2766
V
G
S
P
D
A
C
T
P
L
E
A
P
E
S
Site 358
S2779
E
S
L
M
L
K
I
S
A
N
S
T
R
P
A
Site 359
S2782
M
L
K
I
S
A
N
S
T
R
P
A
R
W
Y
Site 360
T2783
L
K
I
S
A
N
S
T
R
P
A
R
W
Y
T
Site 361
Y2789
S
T
R
P
A
R
W
Y
T
K
L
G
F
F
P
Site 362
T2790
T
R
P
A
R
W
Y
T
K
L
G
F
F
P
D
Site 363
S2806
R
P
F
P
L
P
L
S
S
L
F
S
D
G
G
Site 364
S2807
P
F
P
L
P
L
S
S
L
F
S
D
G
G
N
Site 365
T2834
P
I
Q
W
M
E
K
T
S
S
G
L
Y
I
F
Site 366
Y2839
E
K
T
S
S
G
L
Y
I
F
R
N
E
R
E
Site 367
Y2854
E
E
K
E
A
A
K
Y
V
E
A
Q
Q
K
R
Site 368
T2867
K
R
L
E
A
L
F
T
K
I
Q
E
E
F
E
Site 369
T2881
E
E
H
E
E
N
T
T
K
P
Y
L
P
S
R
Site 370
T2891
Y
L
P
S
R
A
L
T
R
Q
Q
V
R
A
L
Site 371
Y2905
L
Q
D
G
A
E
L
Y
E
A
V
K
N
A
A
Site 372
Y2916
K
N
A
A
D
P
A
Y
L
E
G
Y
F
S
E
Site 373
Y2920
D
P
A
Y
L
E
G
Y
F
S
E
E
Q
L
R
Site 374
S2922
A
Y
L
E
G
Y
F
S
E
E
Q
L
R
A
L
Site 375
S2954
E
I
R
K
A
M
E
S
A
E
Q
K
E
Q
G
Site 376
S2963
E
Q
K
E
Q
G
L
S
R
D
V
T
T
V
W
Site 377
T2967
Q
G
L
S
R
D
V
T
T
V
W
K
L
R
I
Site 378
T2968
G
L
S
R
D
V
T
T
V
W
K
L
R
I
V
Site 379
S2976
V
W
K
L
R
I
V
S
Y
S
K
K
E
K
D
Site 380
S2978
K
L
R
I
V
S
Y
S
K
K
E
K
D
S
V
Site 381
S2984
Y
S
K
K
E
K
D
S
V
I
L
S
I
W
R
Site 382
S2988
E
K
D
S
V
I
L
S
I
W
R
P
S
S
D
Site 383
Y2997
W
R
P
S
S
D
L
Y
S
L
L
T
E
G
K
Site 384
S2998
R
P
S
S
D
L
Y
S
L
L
T
E
G
K
R
Site 385
T3001
S
D
L
Y
S
L
L
T
E
G
K
R
Y
R
I
Site 386
Y3006
L
L
T
E
G
K
R
Y
R
I
Y
H
L
A
T
Site 387
Y3009
E
G
K
R
Y
R
I
Y
H
L
A
T
S
K
S
Site 388
S3014
R
I
Y
H
L
A
T
S
K
S
K
S
K
S
E
Site 389
S3016
Y
H
L
A
T
S
K
S
K
S
K
S
E
R
A
Site 390
S3018
L
A
T
S
K
S
K
S
K
S
E
R
A
N
I
Site 391
S3020
T
S
K
S
K
S
K
S
E
R
A
N
I
Q
L
Site 392
S3041
Q
Y
Q
Q
L
P
V
S
D
E
I
L
F
Q
I
Site 393
Y3049
D
E
I
L
F
Q
I
Y
Q
P
R
E
P
L
H
Site 394
S3068
L
D
P
D
F
Q
P
S
C
S
E
V
D
L
I
Site 395
S3070
P
D
F
Q
P
S
C
S
E
V
D
L
I
G
F
Site 396
S3131
N
L
Q
W
R
P
E
S
K
S
G
L
L
T
L
Site 397
S3133
Q
W
R
P
E
S
K
S
G
L
L
T
L
F
A
Site 398
S3147
A
G
D
F
S
V
F
S
A
S
P
K
E
G
H
Site 399
S3149
D
F
S
V
F
S
A
S
P
K
E
G
H
F
Q
Site 400
T3158
K
E
G
H
F
Q
E
T
F
N
K
M
K
N
T
Site 401
T3193
A
N
D
P
K
W
S
T
P
T
K
D
C
T
S
Site 402
T3199
S
T
P
T
K
D
C
T
S
G
P
Y
T
A
Q
Site 403
S3200
T
P
T
K
D
C
T
S
G
P
Y
T
A
Q
I
Site 404
T3204
D
C
T
S
G
P
Y
T
A
Q
I
I
P
G
T
Site 405
S3219
G
N
K
L
L
M
S
S
P
N
C
E
I
Y
Y
Site 406
Y3225
S
S
P
N
C
E
I
Y
Y
Q
S
P
L
S
L
Site 407
Y3226
S
P
N
C
E
I
Y
Y
Q
S
P
L
S
L
C
Site 408
S3231
I
Y
Y
Q
S
P
L
S
L
C
M
A
K
R
K
Site 409
S3239
L
C
M
A
K
R
K
S
V
S
T
P
V
S
A
Site 410
S3241
M
A
K
R
K
S
V
S
T
P
V
S
A
Q
M
Site 411
T3242
A
K
R
K
S
V
S
T
P
V
S
A
Q
M
T
Site 412
S3245
K
S
V
S
T
P
V
S
A
Q
M
T
S
K
S
Site 413
T3249
T
P
V
S
A
Q
M
T
S
K
S
C
K
G
E
Site 414
S3252
S
A
Q
M
T
S
K
S
C
K
G
E
K
E
I
Site 415
S3275
R
R
A
L
D
F
L
S
R
L
P
L
P
P
P
Site 416
S3291
S
P
I
C
T
F
V
S
P
A
A
Q
K
A
F
Site 417
S3303
K
A
F
Q
P
P
R
S
C
G
T
K
Y
E
T
Site 418
T3306
Q
P
P
R
S
C
G
T
K
Y
E
T
P
I
K
Site 419
Y3308
P
R
S
C
G
T
K
Y
E
T
P
I
K
K
K
Site 420
T3310
S
C
G
T
K
Y
E
T
P
I
K
K
K
E
L
Site 421
S3319
I
K
K
K
E
L
N
S
P
Q
M
T
P
F
K
Site 422
T3323
E
L
N
S
P
Q
M
T
P
F
K
K
F
N
E
Site 423
S3332
F
K
K
F
N
E
I
S
L
L
E
S
N
S
I
Site 424
S3336
N
E
I
S
L
L
E
S
N
S
I
A
D
E
E
Site 425
S3354
I
N
T
Q
A
L
L
S
G
S
T
G
E
K
Q
Site 426
S3364
T
G
E
K
Q
F
I
S
V
S
E
S
T
R
T
Site 427
S3366
E
K
Q
F
I
S
V
S
E
S
T
R
T
A
P
Site 428
S3368
Q
F
I
S
V
S
E
S
T
R
T
A
P
T
S
Site 429
T3371
S
V
S
E
S
T
R
T
A
P
T
S
S
E
D
Site 430
S3375
S
T
R
T
A
P
T
S
S
E
D
Y
L
R
L
Site 431
Y3379
A
P
T
S
S
E
D
Y
L
R
L
K
R
R
C
Site 432
T3387
L
R
L
K
R
R
C
T
T
S
L
I
K
E
Q
Site 433
T3388
R
L
K
R
R
C
T
T
S
L
I
K
E
Q
E
Site 434
S3389
L
K
R
R
C
T
T
S
L
I
K
E
Q
E
S
Site 435
S3396
S
L
I
K
E
Q
E
S
S
Q
A
S
T
E
E
Site 436
S3397
L
I
K
E
Q
E
S
S
Q
A
S
T
E
E
C
Site 437
S3400
E
Q
E
S
S
Q
A
S
T
E
E
C
E
K
N
Site 438
T3401
Q
E
S
S
Q
A
S
T
E
E
C
E
K
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation