KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMARCA4
Full Name:
Transcription activator BRG1
Alias:
Brahma 1; BRG1; BRG-1; EC 3.6.1.-; Global transcription activator SNF2L4; SMCA4; SN24; SNF2B; SNF2-beta; SNF2L4
Type:
Transcription, coactivator/corepressor, Enzyme, helicase, SNF2/RAD54 family
Mass (Da):
184646
Number AA:
1647
UniProt ID:
P51532
International Prot ID:
IPI00293426
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016514
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0008094
PhosphoSite+
KinaseNET
Biological Process:
GO:0006338
GO:0045749
GO:0010553
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
P
D
P
P
L
G
G
T
P
R
P
G
P
S
P
Site 2
S17
G
T
P
R
P
G
P
S
P
G
P
G
P
S
P
Site 3
S23
P
S
P
G
P
G
P
S
P
G
A
M
L
G
P
Site 4
S31
P
G
A
M
L
G
P
S
P
G
P
S
P
G
S
Site 5
S35
L
G
P
S
P
G
P
S
P
G
S
A
H
S
M
Site 6
S38
S
P
G
P
S
P
G
S
A
H
S
M
M
G
P
Site 7
S41
P
S
P
G
S
A
H
S
M
M
G
P
S
P
G
Site 8
S46
A
H
S
M
M
G
P
S
P
G
P
P
S
A
G
Site 9
S51
G
P
S
P
G
P
P
S
A
G
H
P
I
P
T
Site 10
T58
S
A
G
H
P
I
P
T
Q
G
P
G
G
Y
P
Site 11
Y64
P
T
Q
G
P
G
G
Y
P
Q
D
N
M
H
Q
Site 12
S78
Q
M
H
K
P
M
E
S
M
H
E
K
G
M
S
Site 13
S85
S
M
H
E
K
G
M
S
D
D
P
R
Y
N
Q
Site 14
Y90
G
M
S
D
D
P
R
Y
N
Q
M
K
G
M
G
Site 15
S100
M
K
G
M
G
M
R
S
G
G
H
A
G
M
G
Site 16
S111
A
G
M
G
P
P
P
S
P
M
D
Q
H
S
Q
Site 17
S117
P
S
P
M
D
Q
H
S
Q
G
Y
P
S
P
L
Site 18
Y120
M
D
Q
H
S
Q
G
Y
P
S
P
L
G
G
S
Site 19
S122
Q
H
S
Q
G
Y
P
S
P
L
G
G
S
E
H
Site 20
S127
Y
P
S
P
L
G
G
S
E
H
A
S
S
P
V
Site 21
S131
L
G
G
S
E
H
A
S
S
P
V
P
A
S
G
Site 22
S132
G
G
S
E
H
A
S
S
P
V
P
A
S
G
P
Site 23
S137
A
S
S
P
V
P
A
S
G
P
S
S
G
P
Q
Site 24
S140
P
V
P
A
S
G
P
S
S
G
P
Q
M
S
S
Site 25
S141
V
P
A
S
G
P
S
S
G
P
Q
M
S
S
G
Site 26
S146
P
S
S
G
P
Q
M
S
S
G
P
G
G
A
P
Site 27
S147
S
S
G
P
Q
M
S
S
G
P
G
G
A
P
L
Site 28
T170
G
Q
Q
N
R
G
P
T
P
F
N
Q
N
Q
L
Site 29
T219
G
M
Q
Q
Q
M
P
T
L
P
P
P
S
V
S
Site 30
S224
M
P
T
L
P
P
P
S
V
S
A
T
G
P
G
Site 31
S226
T
L
P
P
P
S
V
S
A
T
G
P
G
P
G
Site 32
T228
P
P
P
S
V
S
A
T
G
P
G
P
G
P
G
Site 33
Y249
P
G
P
A
P
P
N
Y
S
R
P
H
G
M
G
Site 34
S250
G
P
A
P
P
N
Y
S
R
P
H
G
M
G
G
Site 35
S266
N
M
P
P
P
G
P
S
G
V
P
P
G
M
P
Site 36
S297
A
N
A
A
A
P
T
S
T
P
Q
K
L
I
P
Site 37
T298
N
A
A
A
P
T
S
T
P
Q
K
L
I
P
P
Site 38
T308
K
L
I
P
P
Q
P
T
G
R
P
S
P
A
P
Site 39
S312
P
Q
P
T
G
R
P
S
P
A
P
P
A
V
P
Site 40
S323
P
A
V
P
P
A
A
S
P
V
M
P
P
Q
T
Site 41
T330
S
P
V
M
P
P
Q
T
Q
S
P
G
Q
P
A
Site 42
S332
V
M
P
P
Q
T
Q
S
P
G
Q
P
A
Q
P
Site 43
S350
V
P
L
H
Q
K
Q
S
R
I
T
P
I
Q
K
Site 44
T353
H
Q
K
Q
S
R
I
T
P
I
Q
K
P
R
G
Site 45
Y372
E
I
L
Q
E
R
E
Y
R
L
Q
A
R
I
A
Site 46
S391
E
L
E
N
L
P
G
S
L
A
G
D
L
R
T
Site 47
S442
N
A
K
A
Y
K
R
S
K
R
Q
S
L
R
E
Site 48
S446
Y
K
R
S
K
R
Q
S
L
R
E
A
R
I
T
Site 49
T453
S
L
R
E
A
R
I
T
E
K
L
E
K
Q
Q
Site 50
Y475
R
R
Q
K
H
Q
E
Y
L
N
S
I
L
Q
H
Site 51
S478
K
H
Q
E
Y
L
N
S
I
L
Q
H
A
K
D
Site 52
Y489
H
A
K
D
F
K
E
Y
H
R
S
V
T
G
K
Site 53
S492
D
F
K
E
Y
H
R
S
V
T
G
K
I
Q
K
Site 54
T494
K
E
Y
H
R
S
V
T
G
K
I
Q
K
L
T
Site 55
T501
T
G
K
I
Q
K
L
T
K
A
V
A
T
Y
H
Site 56
Y538
M
A
E
D
E
E
G
Y
R
K
L
I
D
Q
K
Site 57
Y552
K
K
D
K
R
L
A
Y
L
L
Q
Q
T
D
E
Site 58
Y560
L
L
Q
Q
T
D
E
Y
V
A
N
L
T
E
L
Site 59
T565
D
E
Y
V
A
N
L
T
E
L
V
R
Q
H
K
Site 60
T596
A
E
N
A
E
G
Q
T
P
A
I
G
P
D
G
Site 61
T609
D
G
E
P
L
D
E
T
S
Q
M
S
D
L
P
Site 62
S610
G
E
P
L
D
E
T
S
Q
M
S
D
L
P
V
Site 63
S613
L
D
E
T
S
Q
M
S
D
L
P
V
K
V
I
Site 64
T631
S
G
K
I
L
T
G
T
D
A
P
K
A
G
Q
Site 65
Y649
W
L
E
M
N
P
G
Y
E
V
A
P
R
S
D
Site 66
S655
G
Y
E
V
A
P
R
S
D
S
E
E
S
G
S
Site 67
S657
E
V
A
P
R
S
D
S
E
E
S
G
S
E
E
Site 68
S660
P
R
S
D
S
E
E
S
G
S
E
E
E
E
E
Site 69
S662
S
D
S
E
E
S
G
S
E
E
E
E
E
E
E
Site 70
T681
P
Q
A
A
Q
P
P
T
L
P
V
E
E
K
K
Site 71
S695
K
K
I
P
D
P
D
S
D
D
V
S
E
V
D
Site 72
S699
D
P
D
S
D
D
V
S
E
V
D
A
R
H
I
Site 73
Y718
K
Q
D
V
D
D
E
Y
G
V
S
Q
A
L
A
Site 74
S721
V
D
D
E
Y
G
V
S
Q
A
L
A
R
G
L
Site 75
S746
T
E
R
V
D
K
Q
S
A
L
M
V
N
G
V
Site 76
Y757
V
N
G
V
L
K
Q
Y
Q
I
K
G
L
E
W
Site 77
S767
K
G
L
E
W
L
V
S
L
Y
N
N
N
L
N
Site 78
Y820
S
T
L
S
N
W
A
Y
E
F
D
K
W
A
P
Site 79
S828
E
F
D
K
W
A
P
S
V
V
K
V
S
Y
K
Site 80
S833
A
P
S
V
V
K
V
S
Y
K
G
S
P
A
A
Site 81
S837
V
K
V
S
Y
K
G
S
P
A
A
R
R
A
F
Site 82
Y877
L
A
K
I
R
W
K
Y
M
I
V
D
E
G
H
Site 83
Y901
T
Q
V
L
N
T
H
Y
V
A
P
R
R
L
L
Site 84
T910
A
P
R
R
L
L
L
T
G
T
P
L
Q
N
K
Site 85
T912
R
R
L
L
L
T
G
T
P
L
Q
N
K
L
P
Site 86
Y994
Q
L
P
E
K
V
E
Y
V
I
K
C
D
M
S
Site 87
Y1008
S
A
L
Q
R
V
L
Y
R
H
M
Q
A
K
G
Site 88
S1022
G
V
L
L
T
D
G
S
E
K
D
K
K
G
K
Site 89
T1034
K
G
K
G
G
T
K
T
L
M
N
T
I
M
Q
Site 90
S1060
Q
H
I
E
E
S
F
S
E
H
L
G
F
T
G
Site 91
Y1076
I
V
Q
G
L
D
L
Y
R
A
S
G
K
F
E
Site 92
S1079
G
L
D
L
Y
R
A
S
G
K
F
E
L
L
D
Site 93
Y1115
L
M
T
I
M
E
D
Y
F
A
Y
R
G
F
K
Site 94
Y1123
F
A
Y
R
G
F
K
Y
L
R
L
D
G
T
T
Site 95
T1129
K
Y
L
R
L
D
G
T
T
K
A
E
D
R
G
Site 96
T1130
Y
L
R
L
D
G
T
T
K
A
E
D
R
G
M
Site 97
T1141
D
R
G
M
L
L
K
T
F
N
E
P
G
S
E
Site 98
S1147
K
T
F
N
E
P
G
S
E
Y
F
I
F
L
L
Site 99
Y1220
K
I
L
A
A
A
K
Y
K
L
N
V
D
Q
K
Site 100
S1238
A
G
M
F
D
Q
K
S
S
S
H
E
R
R
A
Site 101
S1240
M
F
D
Q
K
S
S
S
H
E
R
R
A
F
L
Site 102
S1259
E
H
E
E
Q
D
E
S
R
H
C
S
T
G
S
Site 103
S1263
Q
D
E
S
R
H
C
S
T
G
S
G
S
A
S
Site 104
T1264
D
E
S
R
H
C
S
T
G
S
G
S
A
S
F
Site 105
S1266
S
R
H
C
S
T
G
S
G
S
A
S
F
A
H
Site 106
S1270
S
T
G
S
G
S
A
S
F
A
H
T
A
P
P
Site 107
T1301
D
E
V
P
D
D
E
T
V
N
Q
M
I
A
R
Site 108
T1358
D
A
E
V
E
R
L
T
C
E
E
E
E
E
K
Site 109
S1371
E
K
M
F
G
R
G
S
R
H
R
K
E
V
D
Site 110
Y1379
R
H
R
K
E
V
D
Y
S
D
S
L
T
E
K
Site 111
S1380
H
R
K
E
V
D
Y
S
D
S
L
T
E
K
Q
Site 112
S1382
K
E
V
D
Y
S
D
S
L
T
E
K
Q
W
L
Site 113
T1384
V
D
Y
S
D
S
L
T
E
K
Q
W
L
K
A
Site 114
T1396
L
K
A
I
E
E
G
T
L
E
E
I
E
E
E
Site 115
S1409
E
E
V
R
Q
K
K
S
S
R
K
R
K
R
D
Site 116
S1410
E
V
R
Q
K
K
S
S
R
K
R
K
R
D
S
Site 117
S1417
S
R
K
R
K
R
D
S
D
A
G
S
S
T
P
Site 118
S1421
K
R
D
S
D
A
G
S
S
T
P
T
T
S
T
Site 119
S1422
R
D
S
D
A
G
S
S
T
P
T
T
S
T
R
Site 120
T1423
D
S
D
A
G
S
S
T
P
T
T
S
T
R
S
Site 121
T1425
D
A
G
S
S
T
P
T
T
S
T
R
S
R
D
Site 122
T1426
A
G
S
S
T
P
T
T
S
T
R
S
R
D
K
Site 123
S1427
G
S
S
T
P
T
T
S
T
R
S
R
D
K
D
Site 124
T1428
S
S
T
P
T
T
S
T
R
S
R
D
K
D
D
Site 125
S1437
S
R
D
K
D
D
E
S
K
K
Q
K
K
R
G
Site 126
S1452
R
P
P
A
E
K
L
S
P
N
P
P
N
L
T
Site 127
Y1472
I
V
D
A
V
I
K
Y
K
D
S
S
S
G
R
Site 128
S1475
A
V
I
K
Y
K
D
S
S
S
G
R
Q
L
S
Site 129
S1476
V
I
K
Y
K
D
S
S
S
G
R
Q
L
S
E
Site 130
S1477
I
K
Y
K
D
S
S
S
G
R
Q
L
S
E
V
Site 131
S1482
S
S
S
G
R
Q
L
S
E
V
F
I
Q
L
P
Site 132
S1490
E
V
F
I
Q
L
P
S
R
K
E
L
P
E
Y
Site 133
Y1497
S
R
K
E
L
P
E
Y
Y
E
L
I
R
K
P
Site 134
Y1519
E
R
I
R
N
H
K
Y
R
S
L
N
D
L
E
Site 135
S1521
I
R
N
H
K
Y
R
S
L
N
D
L
E
K
D
Site 136
S1544
Q
T
F
N
L
E
G
S
L
I
Y
E
D
S
I
Site 137
S1555
E
D
S
I
V
L
Q
S
V
F
T
S
V
R
Q
Site 138
S1559
V
L
Q
S
V
F
T
S
V
R
Q
K
I
E
K
Site 139
S1570
K
I
E
K
E
D
D
S
E
G
E
E
S
E
E
Site 140
S1575
D
D
S
E
G
E
E
S
E
E
E
E
E
G
E
Site 141
S1586
E
E
G
E
E
E
G
S
E
S
E
S
R
S
V
Site 142
S1588
G
E
E
E
G
S
E
S
E
S
R
S
V
K
V
Site 143
S1590
E
E
G
S
E
S
E
S
R
S
V
K
V
K
I
Site 144
S1592
G
S
E
S
E
S
R
S
V
K
V
K
I
K
L
Site 145
S1617
K
G
G
R
R
R
P
S
R
G
S
R
A
K
P
Site 146
S1620
R
R
R
P
S
R
G
S
R
A
K
P
V
V
S
Site 147
S1627
S
R
A
K
P
V
V
S
D
D
D
S
E
E
E
Site 148
S1631
P
V
V
S
D
D
D
S
E
E
E
Q
E
E
D
Site 149
S1640
E
E
Q
E
E
D
R
S
G
S
G
S
E
E
D
Site 150
S1642
Q
E
E
D
R
S
G
S
G
S
E
E
D
_
_
Site 151
S1644
E
D
R
S
G
S
G
S
E
E
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation