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Updated November 2019
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Protein Info
Short Name:
SMARCA2
Full Name:
Probable global transcription activator SNF2L2
Alias:
ATP-dependent helicase SMARCA2; BRM; EC 3.6.1.-; HBRM; SMCA2; SNF2A; SNF2-alpha; SNF2L2
Type:
EC 3.6.1.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
181279
Number AA:
1590
UniProt ID:
P51531
International Prot ID:
IPI00514648
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016514
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0008094
PhosphoSite+
KinaseNET
Biological Process:
GO:0006338
GO:0010553
GO:0010552
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
M
P
H
P
G
P
S
P
G
P
G
P
S
P
Site 2
S22
P
S
P
G
P
G
P
S
P
G
P
I
L
G
P
Site 3
S30
P
G
P
I
L
G
P
S
P
G
P
G
P
S
P
Site 4
S36
P
S
P
G
P
G
P
S
P
G
S
V
H
S
M
Site 5
S39
G
P
G
P
S
P
G
S
V
H
S
M
M
G
P
Site 6
S42
P
S
P
G
S
V
H
S
M
M
G
P
S
P
G
Site 7
S47
V
H
S
M
M
G
P
S
P
G
P
P
S
V
S
Site 8
S52
G
P
S
P
G
P
P
S
V
S
H
P
M
P
T
Site 9
S54
S
P
G
P
P
S
V
S
H
P
M
P
T
M
G
Site 10
S62
H
P
M
P
T
M
G
S
T
D
F
P
Q
E
G
Site 11
T63
P
M
P
T
M
G
S
T
D
F
P
Q
E
G
M
Site 12
T97
H
C
G
S
M
K
G
T
G
M
R
P
P
H
P
Site 13
S111
P
G
M
G
P
P
Q
S
P
M
D
Q
H
S
Q
Site 14
S117
Q
S
P
M
D
Q
H
S
Q
G
Y
M
S
P
H
Site 15
Y120
M
D
Q
H
S
Q
G
Y
M
S
P
H
P
S
P
Site 16
S122
Q
H
S
Q
G
Y
M
S
P
H
P
S
P
L
G
Site 17
S126
G
Y
M
S
P
H
P
S
P
L
G
A
P
E
H
Site 18
S135
L
G
A
P
E
H
V
S
S
P
M
S
G
G
G
Site 19
S136
G
A
P
E
H
V
S
S
P
M
S
G
G
G
P
Site 20
S139
E
H
V
S
S
P
M
S
G
G
G
P
T
P
P
Site 21
T144
P
M
S
G
G
G
P
T
P
P
Q
M
P
P
S
Site 22
S151
T
P
P
Q
M
P
P
S
Q
P
G
A
L
I
P
Site 23
S165
P
G
D
P
Q
A
M
S
Q
P
N
R
G
P
S
Site 24
S172
S
Q
P
N
R
G
P
S
P
F
S
P
V
Q
L
Site 25
S175
N
R
G
P
S
P
F
S
P
V
Q
L
H
Q
L
Site 26
T201
R
G
Q
P
L
P
E
T
L
Q
L
A
V
Q
G
Site 27
Y259
Q
Q
P
A
L
V
N
Y
N
R
P
S
G
P
G
Site 28
S263
L
V
N
Y
N
R
P
S
G
P
G
P
E
L
S
Site 29
S270
S
G
P
G
P
E
L
S
G
P
S
T
P
Q
K
Site 30
S273
G
P
E
L
S
G
P
S
T
P
Q
K
L
P
V
Site 31
T274
P
E
L
S
G
P
S
T
P
Q
K
L
P
V
P
Site 32
S288
P
A
P
G
G
R
P
S
P
A
P
P
A
A
A
Site 33
S316
Q
P
A
P
G
Q
P
S
P
V
L
Q
L
Q
Q
Site 34
S326
L
Q
L
Q
Q
K
Q
S
R
I
S
P
I
Q
K
Site 35
S329
Q
Q
K
Q
S
R
I
S
P
I
Q
K
P
Q
G
Site 36
Y348
E
I
L
Q
E
R
E
Y
R
L
Q
A
R
I
A
Site 37
S367
E
L
E
N
L
P
G
S
L
P
P
D
L
R
T
Site 38
T374
S
L
P
P
D
L
R
T
K
A
T
V
E
L
K
Site 39
T377
P
D
L
R
T
K
A
T
V
E
L
K
A
L
R
Site 40
T404
V
A
C
M
R
R
D
T
T
L
E
T
A
L
N
Site 41
T405
A
C
M
R
R
D
T
T
L
E
T
A
L
N
S
Site 42
T408
R
R
D
T
T
L
E
T
A
L
N
S
K
A
Y
Site 43
Y415
T
A
L
N
S
K
A
Y
K
R
S
K
R
Q
T
Site 44
S418
N
S
K
A
Y
K
R
S
K
R
Q
T
L
R
E
Site 45
T422
Y
K
R
S
K
R
Q
T
L
R
E
A
R
M
T
Site 46
T429
T
L
R
E
A
R
M
T
E
K
L
E
K
Q
Q
Site 47
Y451
R
R
Q
K
H
Q
E
Y
L
N
S
I
L
Q
H
Site 48
S454
K
H
Q
E
Y
L
N
S
I
L
Q
H
A
K
D
Site 49
Y465
H
A
K
D
F
K
E
Y
H
R
S
V
A
G
K
Site 50
S468
D
F
K
E
Y
H
R
S
V
A
G
K
I
Q
K
Site 51
S477
A
G
K
I
Q
K
L
S
K
A
V
A
T
W
H
Site 52
Y514
M
A
E
D
E
E
G
Y
R
K
L
I
D
Q
K
Site 53
Y528
K
K
D
R
R
L
A
Y
L
L
Q
Q
T
D
E
Site 54
Y536
L
L
Q
Q
T
D
E
Y
V
A
N
L
T
N
L
Site 55
S575
E
N
A
E
G
G
E
S
A
L
G
P
D
G
E
Site 56
S587
D
G
E
P
I
D
E
S
S
Q
M
S
D
L
P
Site 57
S588
G
E
P
I
D
E
S
S
Q
M
S
D
L
P
V
Site 58
S591
I
D
E
S
S
Q
M
S
D
L
P
V
K
V
T
Site 59
S615
G
P
E
A
P
K
A
S
Q
L
D
A
W
L
E
Site 60
Y627
W
L
E
M
N
P
G
Y
E
V
A
P
R
S
D
Site 61
S633
G
Y
E
V
A
P
R
S
D
S
E
E
S
D
S
Site 62
S635
E
V
A
P
R
S
D
S
E
E
S
D
S
D
Y
Site 63
S638
P
R
S
D
S
E
E
S
D
S
D
Y
E
E
E
Site 64
S640
S
D
S
E
E
S
D
S
D
Y
E
E
E
D
E
Site 65
Y642
S
E
E
S
D
S
D
Y
E
E
E
D
E
E
E
Site 66
S651
E
E
D
E
E
E
E
S
S
R
Q
E
T
E
E
Site 67
S652
E
D
E
E
E
E
S
S
R
Q
E
T
E
E
K
Site 68
T656
E
E
S
S
R
Q
E
T
E
E
K
I
L
L
D
Site 69
S666
K
I
L
L
D
P
N
S
E
E
V
S
E
K
D
Site 70
S670
D
P
N
S
E
E
V
S
E
K
D
A
K
Q
I
Site 71
Y689
K
Q
D
V
D
D
E
Y
S
M
Q
Y
S
A
R
Site 72
S690
Q
D
V
D
D
E
Y
S
M
Q
Y
S
A
R
G
Site 73
Y693
D
D
E
Y
S
M
Q
Y
S
A
R
G
S
Q
S
Site 74
S694
D
E
Y
S
M
Q
Y
S
A
R
G
S
Q
S
Y
Site 75
S698
M
Q
Y
S
A
R
G
S
Q
S
Y
Y
T
V
A
Site 76
Y701
S
A
R
G
S
Q
S
Y
Y
T
V
A
H
A
I
Site 77
Y702
A
R
G
S
Q
S
Y
Y
T
V
A
H
A
I
S
Site 78
T703
R
G
S
Q
S
Y
Y
T
V
A
H
A
I
S
E
Site 79
S709
Y
T
V
A
H
A
I
S
E
R
V
E
K
Q
S
Site 80
S716
S
E
R
V
E
K
Q
S
A
L
L
I
N
G
T
Site 81
T723
S
A
L
L
I
N
G
T
L
K
H
Y
Q
L
Q
Site 82
Y727
I
N
G
T
L
K
H
Y
Q
L
Q
G
L
E
W
Site 83
Y739
L
E
W
M
V
S
L
Y
N
N
N
L
N
G
I
Site 84
Y790
S
T
L
S
N
W
T
Y
E
F
D
K
W
A
P
Site 85
S798
E
F
D
K
W
A
P
S
V
V
K
I
S
Y
K
Site 86
T807
V
K
I
S
Y
K
G
T
P
A
M
R
R
S
L
Site 87
S813
G
T
P
A
M
R
R
S
L
V
P
Q
L
R
S
Site 88
Y847
L
A
K
I
R
W
K
Y
M
I
V
D
E
G
H
Site 89
Y871
T
Q
V
L
N
T
H
Y
V
A
P
R
R
I
L
Site 90
T880
A
P
R
R
I
L
L
T
G
T
P
L
Q
N
K
Site 91
T882
R
R
I
L
L
T
G
T
P
L
Q
N
K
L
P
Site 92
S956
R
L
K
K
E
V
E
S
Q
L
P
E
K
V
E
Site 93
Y964
Q
L
P
E
K
V
E
Y
V
I
K
C
D
M
S
Site 94
S971
Y
V
I
K
C
D
M
S
A
L
Q
K
I
L
Y
Site 95
Y978
S
A
L
Q
K
I
L
Y
R
H
M
Q
A
K
G
Site 96
S992
G
I
L
L
T
D
G
S
E
K
D
K
K
G
K
Site 97
T1004
K
G
K
G
G
A
K
T
L
M
N
T
I
M
Q
Site 98
T1008
G
A
K
T
L
M
N
T
I
M
Q
L
R
K
I
Site 99
Y1020
R
K
I
C
N
H
P
Y
M
F
Q
H
I
E
E
Site 100
Y1035
S
F
A
E
H
L
G
Y
S
N
G
V
I
N
G
Site 101
Y1046
V
I
N
G
A
E
L
Y
R
A
S
G
K
F
E
Site 102
S1049
G
A
E
L
Y
R
A
S
G
K
F
E
L
L
D
Site 103
T1099
L
Y
L
R
L
D
G
T
T
K
S
E
D
R
A
Site 104
T1100
Y
L
R
L
D
G
T
T
K
S
E
D
R
A
A
Site 105
S1102
R
L
D
G
T
T
K
S
E
D
R
A
A
L
L
Site 106
S1117
K
K
F
N
E
P
G
S
Q
Y
F
I
F
L
L
Site 107
Y1190
K
I
L
A
A
A
K
Y
K
L
N
V
D
Q
K
Site 108
S1208
A
G
M
F
D
Q
K
S
S
S
H
E
R
R
A
Site 109
S1210
M
F
D
Q
K
S
S
S
H
E
R
R
A
F
L
Site 110
T1238
D
E
V
P
D
D
E
T
L
N
Q
M
I
A
R
Site 111
T1295
D
A
E
V
E
R
L
T
C
E
E
E
E
E
K
Site 112
S1308
E
K
I
F
G
R
G
S
R
Q
R
R
D
V
D
Site 113
Y1316
R
Q
R
R
D
V
D
Y
S
D
A
L
T
E
K
Site 114
S1317
Q
R
R
D
V
D
Y
S
D
A
L
T
E
K
Q
Site 115
T1321
V
D
Y
S
D
A
L
T
E
K
Q
W
L
R
A
Site 116
S1377
R
P
P
A
E
K
L
S
P
N
P
P
K
L
T
Site 117
S1408
C
N
V
E
K
V
P
S
N
S
Q
L
E
I
E
Site 118
S1410
V
E
K
V
P
S
N
S
Q
L
E
I
E
G
N
Site 119
S1418
Q
L
E
I
E
G
N
S
S
G
R
Q
L
S
E
Site 120
S1419
L
E
I
E
G
N
S
S
G
R
Q
L
S
E
V
Site 121
S1424
N
S
S
G
R
Q
L
S
E
V
F
I
Q
L
P
Site 122
S1432
E
V
F
I
Q
L
P
S
R
K
E
L
P
E
Y
Site 123
Y1439
S
R
K
E
L
P
E
Y
Y
E
L
I
R
K
P
Site 124
Y1461
E
R
I
R
N
H
K
Y
R
S
L
G
D
L
E
Site 125
S1463
I
R
N
H
K
Y
R
S
L
G
D
L
E
K
D
Site 126
T1480
L
L
C
H
N
A
Q
T
F
N
L
E
G
S
Q
Site 127
S1486
Q
T
F
N
L
E
G
S
Q
I
Y
E
D
S
I
Site 128
S1497
E
D
S
I
V
L
Q
S
V
F
K
S
A
R
Q
Site 129
S1501
V
L
Q
S
V
F
K
S
A
R
Q
K
I
A
K
Site 130
S1512
K
I
A
K
E
E
E
S
E
D
E
S
N
E
E
Site 131
S1516
E
E
E
S
E
D
E
S
N
E
E
E
E
E
E
Site 132
S1528
E
E
E
D
E
E
E
S
E
S
E
A
K
S
V
Site 133
S1530
E
D
E
E
E
S
E
S
E
A
K
S
V
K
V
Site 134
S1534
E
S
E
S
E
A
K
S
V
K
V
K
I
K
L
Site 135
S1568
G
K
A
K
P
V
V
S
D
F
D
S
D
E
E
Site 136
S1572
P
V
V
S
D
F
D
S
D
E
E
Q
D
E
R
Site 137
S1582
E
Q
D
E
R
E
Q
S
E
G
S
G
T
D
D
Site 138
S1585
E
R
E
Q
S
E
G
S
G
T
D
D
E
_
_
Site 139
T1587
E
Q
S
E
G
S
G
T
D
D
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation