KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DNA2
Full Name:
DNA2-like helicase
Alias:
DNA replication ATP-dependent helicase-like; DNA replication ATP-dependent helicase-like homolog; DNA replication helicase 2; DNA2L; EC 3.6.1.-; KIAA0083
Type:
Helicase; EC 3.6.1.-
Mass (Da):
120415
Number AA:
1060
UniProt ID:
P51530
International Prot ID:
IPI00216142
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0017108
GO:0005524
GO:0004003
PhosphoSite+
KinaseNET
Biological Process:
GO:0043137
GO:0006284
GO:0006264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
E
L
L
M
E
K
S
F
W
E
E
A
E
L
Site 2
S40
S
F
P
R
T
V
L
S
T
G
M
D
N
R
Y
Site 3
T41
F
P
R
T
V
L
S
T
G
M
D
N
R
Y
L
Site 4
Y47
S
T
G
M
D
N
R
Y
L
V
L
A
V
N
T
Site 5
T69
C
E
K
R
L
V
I
T
A
S
Q
S
L
E
N
Site 6
S71
K
R
L
V
I
T
A
S
Q
S
L
E
N
K
E
Site 7
S88
I
L
R
N
D
W
C
S
V
P
V
E
P
G
D
Site 8
S133
S
G
T
S
I
A
S
S
I
R
C
M
R
R
A
Site 9
S143
C
M
R
R
A
V
L
S
E
T
F
R
S
S
D
Site 10
T145
R
R
A
V
L
S
E
T
F
R
S
S
D
P
A
Site 11
S148
V
L
S
E
T
F
R
S
S
D
P
A
T
R
Q
Site 12
S149
L
S
E
T
F
R
S
S
D
P
A
T
R
Q
M
Site 13
T153
F
R
S
S
D
P
A
T
R
Q
M
L
I
G
T
Site 14
S173
F
Q
K
A
I
N
N
S
F
A
P
E
K
L
Q
Site 15
S202
E
M
Y
R
L
N
L
S
Q
D
E
I
K
Q
E
Site 16
Y213
I
K
Q
E
V
E
D
Y
L
P
S
F
C
K
W
Site 17
T231
F
M
H
K
N
T
S
T
D
F
P
Q
M
Q
L
Site 18
S239
D
F
P
Q
M
Q
L
S
L
P
S
D
N
S
K
Site 19
S242
Q
M
Q
L
S
L
P
S
D
N
S
K
D
N
S
Site 20
S245
L
S
L
P
S
D
N
S
K
D
N
S
T
C
N
Site 21
S249
S
D
N
S
K
D
N
S
T
C
N
I
E
V
V
Site 22
S264
K
P
M
D
I
E
E
S
I
W
S
P
R
F
G
Site 23
S267
D
I
E
E
S
I
W
S
P
R
F
G
L
K
G
Site 24
Y288
G
V
K
I
H
R
G
Y
K
T
K
Y
K
I
M
Site 25
T290
K
I
H
R
G
Y
K
T
K
Y
K
I
M
P
L
Site 26
Y292
H
R
G
Y
K
T
K
Y
K
I
M
P
L
E
L
Site 27
T301
I
M
P
L
E
L
K
T
G
K
E
S
N
S
I
Site 28
S312
S
N
S
I
E
H
R
S
Q
V
V
L
Y
T
L
Site 29
Y317
H
R
S
Q
V
V
L
Y
T
L
L
S
Q
E
R
Site 30
T318
R
S
Q
V
V
L
Y
T
L
L
S
Q
E
R
R
Site 31
S321
V
V
L
Y
T
L
L
S
Q
E
R
R
A
D
P
Site 32
Y342
Y
L
K
T
G
Q
M
Y
P
V
P
A
N
H
L
Site 33
S364
L
R
N
Q
M
A
F
S
L
F
H
R
I
S
K
Site 34
S370
F
S
L
F
H
R
I
S
K
S
A
T
R
Q
K
Site 35
S372
L
F
H
R
I
S
K
S
A
T
R
Q
K
T
Q
Site 36
T374
H
R
I
S
K
S
A
T
R
Q
K
T
Q
L
A
Site 37
T378
K
S
A
T
R
Q
K
T
Q
L
A
S
L
P
Q
Site 38
Y395
E
E
E
K
T
C
K
Y
C
S
Q
I
G
N
C
Site 39
Y405
Q
I
G
N
C
A
L
Y
S
R
A
V
E
Q
Q
Site 40
T449
S
L
W
C
L
M
L
T
L
E
S
Q
S
K
D
Site 41
S452
C
L
M
L
T
L
E
S
Q
S
K
D
N
K
K
Site 42
S470
N
I
W
L
M
P
A
S
E
M
E
K
S
G
S
Site 43
S475
P
A
S
E
M
E
K
S
G
S
C
I
G
N
L
Site 44
S477
S
E
M
E
K
S
G
S
C
I
G
N
L
I
R
Site 45
Y496
K
I
V
C
D
G
Q
Y
L
H
N
F
Q
C
K
Site 46
S521
A
G
D
R
V
I
V
S
G
E
E
R
S
L
F
Site 47
S526
I
V
S
G
E
E
R
S
L
F
A
L
S
R
G
Site 48
S531
E
R
S
L
F
A
L
S
R
G
Y
V
K
E
I
Site 49
S557
N
L
S
V
L
P
E
S
T
L
F
R
L
D
Q
Site 50
T573
E
K
N
C
D
I
D
T
P
L
G
N
L
S
K
Site 51
T585
L
S
K
L
M
E
N
T
F
V
S
K
K
L
R
Site 52
Y606
R
E
P
Q
F
I
S
Y
L
S
S
V
L
P
H
Site 53
S609
Q
F
I
S
Y
L
S
S
V
L
P
H
D
A
K
Site 54
S720
T
E
Q
E
I
C
R
S
K
S
I
K
S
L
A
Site 55
S725
C
R
S
K
S
I
K
S
L
A
L
L
E
E
L
Site 56
S768
V
D
E
A
S
Q
I
S
Q
P
I
C
L
G
P
Site 57
S806
E
A
R
A
L
G
M
S
E
S
L
F
K
R
L
Site 58
S808
R
A
L
G
M
S
E
S
L
F
K
R
L
E
Q
Site 59
S818
K
R
L
E
Q
N
K
S
A
V
V
Q
L
T
V
Site 60
T824
K
S
A
V
V
Q
L
T
V
Q
Y
R
M
N
S
Site 61
S831
T
V
Q
Y
R
M
N
S
K
I
M
S
L
S
N
Site 62
S835
R
M
N
S
K
I
M
S
L
S
N
K
L
T
Y
Site 63
T841
M
S
L
S
N
K
L
T
Y
E
G
K
L
E
C
Site 64
Y842
S
L
S
N
K
L
T
Y
E
G
K
L
E
C
G
Site 65
Y873
V
K
L
E
L
E
F
Y
A
D
Y
S
D
N
P
Site 66
Y876
E
L
E
F
Y
A
D
Y
S
D
N
P
W
L
M
Site 67
Y943
D
I
G
I
I
A
P
Y
R
Q
Q
L
K
I
I
Site 68
T965
I
G
M
V
E
V
N
T
V
D
K
Y
Q
G
R
Site 69
Y969
E
V
N
T
V
D
K
Y
Q
G
R
D
K
S
I
Site 70
S975
K
Y
Q
G
R
D
K
S
I
V
L
V
S
F
V
Site 71
S980
D
K
S
I
V
L
V
S
F
V
R
S
N
K
D
Site 72
T989
V
R
S
N
K
D
G
T
V
G
E
L
L
K
D
Site 73
S1044
K
L
I
I
D
L
P
S
R
E
H
E
S
L
C
Site 74
S1049
L
P
S
R
E
H
E
S
L
C
H
I
L
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation