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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP1A2
Full Name:
Sodium/potassium-transporting ATPase subunit alpha-2
Alias:
AT1A2; ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide; EC 3.6.3.9; FHM2; MHP2; Migraine, hemiplegic 2; Na+/K+-ATPase alpha 2; Sodium pump 2; Sodium/potassium-transporting ATPase alpha-2; Sodium/potassium-transporting ATPase alpha-2 chain; Sodium-potassium ATPase
Type:
EC 3.6.3.9; Membrane protein, integral; Hydrolase; Transporter
Mass (Da):
112265
Number AA:
1020
UniProt ID:
P50993
International Prot ID:
IPI00003021
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005890
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0015077
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006813
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
G
R
G
A
G
R
E
Y
S
P
A
A
T
T
A
Site 2
S10
R
G
A
G
R
E
Y
S
P
A
A
T
T
A
E
Site 3
T14
R
E
Y
S
P
A
A
T
T
A
E
N
G
G
G
Site 4
S45
A
M
D
D
H
K
L
S
L
D
E
L
G
R
K
Site 5
Y53
L
D
E
L
G
R
K
Y
Q
V
D
L
S
K
G
Site 6
S58
R
K
Y
Q
V
D
L
S
K
G
L
T
N
Q
R
Site 7
T62
V
D
L
S
K
G
L
T
N
Q
R
A
Q
D
V
Site 8
T79
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
Site 9
T83
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
Site 10
T84
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
Site 11
S124
A
A
M
E
D
E
P
S
N
D
N
L
Y
L
G
Site 12
Y147
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
Site 13
S152
S
Y
Y
Q
E
A
K
S
S
K
I
M
D
S
F
Site 14
S153
Y
Y
Q
E
A
K
S
S
K
I
M
D
S
F
K
Site 15
S158
K
S
S
K
I
M
D
S
F
K
N
M
V
P
Q
Site 16
S205
P
A
D
L
R
I
I
S
S
H
G
C
K
V
D
Site 17
S206
A
D
L
R
I
I
S
S
H
G
C
K
V
D
N
Site 18
S214
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
Site 19
S215
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Site 20
T217
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
Site 21
S220
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
Site 22
T224
T
G
E
S
E
P
Q
T
R
S
P
E
F
T
H
Site 23
S226
E
S
E
P
Q
T
R
S
P
E
F
T
H
E
N
Site 24
T230
Q
T
R
S
P
E
F
T
H
E
N
P
L
E
T
Site 25
T259
A
R
G
I
V
I
A
T
G
D
R
T
V
M
G
Site 26
S273
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
Site 27
T364
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
Site 28
S367
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
Site 29
T368
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
Site 30
S369
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
Site 31
T370
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
Site 32
S373
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Site 33
T376
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
Site 34
T380
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
Site 35
T400
N
Q
I
H
E
A
D
T
T
E
D
Q
S
G
A
Site 36
T401
Q
I
H
E
A
D
T
T
E
D
Q
S
G
A
T
Site 37
T408
T
E
D
Q
S
G
A
T
F
D
K
R
S
P
T
Site 38
S413
G
A
T
F
D
K
R
S
P
T
W
T
A
L
S
Site 39
T415
T
F
D
K
R
S
P
T
W
T
A
L
S
R
I
Site 40
T417
D
K
R
S
P
T
W
T
A
L
S
R
I
A
G
Site 41
S439
K
A
G
Q
E
N
I
S
V
S
K
R
D
T
A
Site 42
S441
G
Q
E
N
I
S
V
S
K
R
D
T
A
G
D
Site 43
T445
I
S
V
S
K
R
D
T
A
G
D
A
S
E
S
Site 44
S450
R
D
T
A
G
D
A
S
E
S
A
L
L
K
C
Site 45
S464
C
I
E
L
S
C
G
S
V
R
K
M
R
D
R
Site 46
S482
V
A
E
I
P
F
N
S
T
N
K
Y
Q
L
S
Site 47
Y486
P
F
N
S
T
N
K
Y
Q
L
S
I
H
E
R
Site 48
S489
S
T
N
K
Y
Q
L
S
I
H
E
R
E
D
S
Site 49
S496
S
I
H
E
R
E
D
S
P
Q
S
H
V
L
V
Site 50
S499
E
R
E
D
S
P
Q
S
H
V
L
V
M
K
G
Site 51
S516
E
R
I
L
D
R
C
S
T
I
L
V
Q
G
K
Site 52
T517
R
I
L
D
R
C
S
T
I
L
V
Q
G
K
E
Site 53
Y539
Q
D
A
F
Q
N
A
Y
M
E
L
G
G
L
G
Site 54
S559
F
C
Q
L
N
L
P
S
G
K
F
P
R
G
F
Site 55
T570
P
R
G
F
K
F
D
T
D
E
L
N
F
P
T
Site 56
S587
L
C
F
V
G
L
M
S
M
I
D
P
P
R
A
Site 57
T614
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
Site 58
S632
A
K
G
V
G
I
I
S
E
G
N
E
T
V
E
Site 59
T637
I
I
S
E
G
N
E
T
V
E
D
I
A
A
R
Site 60
S650
A
R
L
N
I
P
M
S
Q
V
N
P
R
E
A
Site 61
S665
K
A
C
V
V
H
G
S
D
L
K
D
M
T
S
Site 62
T671
G
S
D
L
K
D
M
T
S
E
Q
L
D
E
I
Site 63
S672
S
D
L
K
D
M
T
S
E
Q
L
D
E
I
L
Site 64
S719
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
Site 65
S739
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
Site 66
S772
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
Site 67
T776
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
Site 68
S826
L
A
Y
E
A
A
E
S
D
I
M
K
R
Q
P
Site 69
S836
M
K
R
Q
P
R
N
S
Q
T
D
K
L
V
N
Site 70
T891
R
L
D
W
D
D
R
T
M
N
D
L
E
D
S
Site 71
Y899
M
N
D
L
E
D
S
Y
G
Q
E
W
T
Y
E
Site 72
T904
D
S
Y
G
Q
E
W
T
Y
E
Q
R
K
V
V
Site 73
Y905
S
Y
G
Q
E
W
T
Y
E
Q
R
K
V
V
E
Site 74
T936
A
D
L
I
I
C
K
T
R
R
N
S
V
F
Q
Site 75
S940
I
C
K
T
R
R
N
S
V
F
Q
Q
G
M
K
Site 76
Y1009
R
K
L
I
L
R
R
Y
P
G
G
W
V
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation